Protein Alignment jar and Myo6

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001395181.1
• Gene: Myo6 / 17920
• MGIID: 104785
• Length: 1294
• Species: Mus musculus
• Alignment Length: 1313
• Identity: 667/1313 - (50%)
• Similarity: 896/1313 - (68%)
• Gaps: 72/1313 - (5%)

  Fly     2 LEDTQLVWVRDAAEGYIQGRITEIGAKEFEVTPTDRK-----------YPKRTCHFDDIHSSCDG 55
            :||.:.||.....:|:..|.|.:||.....:.|.::|           :|...          |.
Mouse     1 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEE----------DS 55

  Fly    56 PQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSL 120
            .:|.:|||.||.|||||.|.|:|.||.||:|||||||||||||||.:|.::|:.||||.|.|:||
Mouse    56 KKDVEDNCSLMYLNEATLLHNVKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSDTIKSYQGKSL 120

  Fly   121 GELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKILDA 185
            |.:|||||||||||.|||:|.|:||||||||||||||||:||::|:||..|:.:...|:.:|::|
Mouse   121 GTMPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEA 185

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ||:|||||||||.|||||||||||:|:|::.|..||||::|||||||||||.|..||||||:||.
Mouse   186 NPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYR 250

  Fly   251 LLAGAPQQLRDKLSLGKPDDYRYLS-GCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ 314
            |.|||.:.:|:||.|..||::|||: |||::|||.:|::.|..::||..:.:.|.||||::||:.
Mouse   251 LCAGASEDIREKLHLSSPDNFRYLNRGCTRFFANKETDKQILQNRKSPEYVKAGSLKDPLLDDHG 315

  Fly   315 HFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLL 379
            .|..:..|:.::||.|.|||.::.:||.|||||||.||| .....|||.:...|..||...:.||
Mouse   316 DFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEE-AGSTSGGCNLKNKSAPSLEYCAELL 379

  Fly   380 GVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIP 444
            |:||.:||.:|.:|||.:..||.|||||.||||:.:|:||||||||.:||.|||.:|..:||..|
Mouse   380 GLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFP 444

  Fly   445 FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            |:.|:::||||||||||||..||||||||||||||||:|||:.|||.|||||::|||.|.|:.:.
Mouse   445 FETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYV 509

  Fly   510 DNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDE 574
            ||||.|:|||.|..||..:||||::||:||..|||:.||:...:|:||.:||.|:|..||.|||:
Mouse   510 DNQDCIDLIEVKLVGILDILDEENRLPQPSDQHFTSVVHQKHKDHFRLTIPRKSKLAVHRNLRDD 574

  Fly   575 EGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTS-----VRGKLN 634
            |||::|||||||||.|.||:||||||||.|||.|:.|..:..::.||.|.::.:     ..|||:
Mouse   575 EGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRALFESSTNNNKDTKQKAGKLS 639

  Fly   635 FISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHG 699
            |||||:||||||..|::||...|.:||||||||.||....|||:..|:||:|||.:|||:||:.|
Mouse   640 FISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGG 704

  Fly   700 YPSRVLFADLYSMYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRI 764
            :|||..|.:||:|||..:|.:|..|..|.||:|:|::|.|:..|:|||:||||||||||.|||:|
Mouse   705 FPSRASFHELYNMYKKYMPEKLARLDPRLFCKALFKALGLNEVDYKFGLTKVFFRPGKFAEFDQI 769

  Fly   765 MRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHR 829
            |:|||:::..:|.:|..||:.|||.|....:|.||||:|:|.||.:..:..|:..|.:|.:::|:
Mouse   770 MKSDPDHLAELVKRVNLWLVCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHK 834

  Fly   830 PRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSM 894
            ||..|:.|:..::....|..|:.|.||.|:.|:...:.::...||..:.||| :..:|:.::...
Mouse   835 PRIDGLVKVGTLKKRLDKFNEVVSALKDGKPEVNRQIKNLEISIDALMAKIK-STMMTREQIQKE 898

  Fly   895 YTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEM 959
            |..::.:...|   |:...|::||.||.||||:|||.:|.||..:|.:|:|:|:|.|.:|:|.||
Mouse   899 YDALVKSSEDL---LSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEERRRKEEEERRMKLEM 960

  Fly   960 ETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVE 1024
            |.:||..|.:|.::|::::|....::.||.::.:::::.:..|.||.||.|||||:|...:..:.
Mouse   961 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQREEESQQQAVLAQECRDRELALRIAQNESELIS 1025

  Fly  1025 D------------SPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQK 1077
            |            |.|...........|.|.::   ::.:|.|.||    ...|:|.:.|.|.:|
Mouse  1026 DEAQGDMALRSLSSCPATSKTNGTRPQMTPEQM---AKEMSEILSR----GPAVQATKAAAGTKK 1083

  Fly  1078 YDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAA 1142
            :|||||||:||||.||||||||||.|||:|||||||||||||:||:||.|..| :|||:||.:..
Mouse  1084 HDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETE-QRAPKSVTDYD 1147

  Fly  1143 F--------KQPPLVQ-PI--QEI-VTAQHRYFRIPFMRA----NAPDNTKRGLWYAHFDGQWIA 1191
            |        :|.|..| |.  ||| :..|.|:|||||:|.    ..|.|.|:|.|||||||.|||
Mouse  1148 FAPFLNNSPQQNPAAQLPARQQEIDMKRQQRFFRIPFIRPADQYKDPQNKKKGWWYAHFDGPWIA 1212

  Fly  1192 RQMELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGAEILEHEFNREWERNGGKAYKNLG--- 1253
            ||||||.||||||||||.|||:||||:|||||||||||||||..:|...|||.||..|....
Mouse  1213 RQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQYLQSAIES 1277

  Fly  1254 -AAKPNGPAAAMQ 1265
             .|:|....|.:|
Mouse  1278 RQARPTYATAMLQ 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/52 (19%)
		MYSc_Myo6	71..754	CDD:276833	404/688 (59%)
		CBD_MYO6-like	765..913	CDD:409646	45/147 (31%)
		ERM_helical	<954..1020	CDD:466641	24/65 (37%)
		MYO6_MIU_linker	1002..1093	CDD:480843	36/102 (35%)
		MyUb_Myo6	1076..1116	CDD:439319	33/39 (85%)
		Myosin-VI_CBD	1160..1246	CDD:465157	63/89 (71%)
Myo6	NP_001395181.1	MYSc_Myo6	71..759	CDD:276833	404/688 (59%)
		CBD_MYO6-like	770..917	CDD:409646	46/150 (31%)
		MYO6_MIU_linker	999..1068	CDD:412090	18/71 (25%)
		MyUb_Myo6	1082..1122	CDD:439319	33/39 (85%)
		Myosin-VI_CBD	1177..1267	CDD:465157	63/89 (71%)