Protein Alignment jar and Myo5b

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_006525777.1
• Gene: Myo5b / 17919
• MGIID: 106598
• Length: 1849
• Species: Mus musculus
• Alignment Length: 1338
• Identity: 392/1338 - (29%)
• Similarity: 627/1338 - (46%)
• Gaps: 229/1338 - (17%)

  Fly     8 VWVRDAAEGYIQGRIT---EIGAKEFEVTPTD---RKYPKRTCHFDDIHSS----CDGPQ---DH 59
            ||:.|..|.:....:|   :.|.|..::...|   .:||.      |:.::    ...|.   ..
Mouse    13 VWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDDTILEYPV------DVQNNQVPFLRNPDILVGE 71

  Fly    60 DDNCELMLLNEATFLDNLKTRYYK-DKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGEL 123
            :|...|..|:|...|.|||.|:.: :.||||...:|:|:|||.:: .:|..|.|..|:|:::|::
Mouse    72 NDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQL-PIYGQDVIYAYSGQNMGDM 135

  Fly   124 PPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGP--IETKILDAN 186
            .||:||:|::|.:.|...:.:||||||||||||||.|.||.::|......||..  ||.|:|.::
Mouse   136 DPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLASS 200

  Fly   187 PVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYML 251
            |::||.||||||||:||||||||||:.:|.|..::|..:..|||||||:..|:.:|||||:||.|
Mouse   201 PIMEAIGNAKTTRNDNSSRFGKFIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQL 265

  Fly   252 LAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHF 316
            .|.|......:|:|...:|:.|    |.:..|...|.                     ::|...|
Mouse   266 CAAASLPEFKELALTCAEDFFY----TAHGGNTTIEG---------------------VNDADDF 305

  Fly   317 HNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRG-GCQVSEASEQSLTITSGLLG 380
            ....:||..||:.|:.::.|:.::|::||||::   ||..:..| .|.:|...|. |:....|||
Mouse   306 EKTRQALTLLGVRDSHQISIFKIIASILHLGSV---EIQSERDGDSCSISPQDEH-LSNFCSLLG 366

  Fly   381 VDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPF 445
            ::.:::...|..|.:.:....:..|     :.:.:..||||||||.||::||..||..||:::..
Mouse   367 IEHSQMEHWLCHRKLVTTSETYVKT-----MSLQQVVNARDALAKHIYAQLFSWIVEHINKALHT 426

  Fly   446 Q-ASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            . ..:.:||||||.|||.|.:||||||||||.|||||:.||.::.|.|||.|.:|.:....|.|.
Mouse   427 SLKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFY 491

  Fly   510 DNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDE 574
            |||..|:|||||. ||..|||||.|:||.:..::..::::..:|......||.|          .
Mouse   492 DNQPCIDLIEAKL-GILDLLDEECKVPKGTDQNWAQKLYERHSNSQHFQKPRMS----------N 545

  Fly   575 EGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF---------------PSG 624
            ..|:|.|||..|.|.::.|:|||.|.::.....:::....||:..||               .|.
Mouse   546 TAFIVNHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDSAPATNTAKNRSS 610

  Fly   625 SSTSVRGKLNFI---------SVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLA 680
            |..:||.....|         |||.:|:|.|..|||.|.....:::||||||.:.:...|:...|
Mouse   611 SKINVRSSRPLIKVPNKEHKKSVGYQFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRA 675

  Fly   681 LAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPP-ELVSLPARTFCEAMFQSLNLSAKDF 744
            :.||:..|.:..:.:...|||||..:.|.::.|:.::.. ||.:...:..|:::.:||......|
Mouse   676 VQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLMKKRELTNTDKKNICKSVLESLIKDPDKF 740

  Fly   745 KFGITKVFFRPGKFVEFDRIMRSDP--ENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIY 807
            :||.||:|||.|:....:: :|:|.  |..:.|...|:.||                   .|:.|
Mouse   741 QFGRTKIFFRAGQVAYLEK-LRADKFREATIMIQKSVRGWL-------------------QRVKY 785

  Fly   808 R--NKCVLIAQRIARGFLARK--QH----------RPRYQGIGKINKIRTNTLKTIEIASGLKMG 858
            |  ....|..||..||:|||:  :|          :.:|:.:......|.....|:.|.|..:
Mouse   786 RRLRAATLSLQRFCRGYLARRLAEHLRRTRAAIVFQKQYRMLKARRAYRRVCRATVIIQSFTR-- 848

  Fly   859 REEIISGVNDIYRQI-----DDAIKKIK---MNPRITQREMDSMYTVVMANMNKLTVDLNTKLKE 915
                ...|...|||:     ...|:|..   |..:...||.|:...:..|         ..:||.
Mouse   849 ----AMFVRRNYRQVLMEHKATIIQKYARGWMARKRFLRERDAAIVIQCA---------FRRLKA 900

  Fly   916 QQ-------QAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEME-----TRRKAAEA 968
            :|       :|...|.|:::...:|    .|..:.||:.:: :||..|...|     |...|.|.
Mouse   901 RQELKALKIEARSAEHLKRLNVGME----NKVVQLQRKIDD-QNKEFKTLSEQLSAVTSSHAVEV 960

  Fly   969 QRLR------QEEEDRRAALALQEQ---LEKEAKDDAKYRQQLE--QERRDHELALRLAN--ESN 1020
            ::|:      |:.::...:|.|||:   |..|.:.....|:.||  ..:.:.||..|:|:  ..|
Mouse   961 EKLKKELAHYQQNQEADTSLQLQEEVQSLRTELQKAHSERRVLEDAHNKENGELRKRVADLEHEN 1025

  Fly  1021 GQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLSKWKY 1085
            ..::|....:.|.:...|....::    |.|..|:..:  .:.|..|::.|.|.|: |...:.:|
Mouse  1026 ALLKDEKEYLNNQILCQSKAESSQ----SSVEENLLMK--KELEEERSRYQNLVKE-YSQLEQRY 1083

  Fly  1086 SELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKN-RKRTTMDENERAPR-SVMEAAFKQPPL 1148
            ..|||      ::.:|:  :...||          || ..:::::.:...|. |..|....:..|
Mouse  1084 ENLRD------EVTILK--QTPGHR----------KNPSNQSSLESDSNYPSISTSEIGDTEDAL 1130

  Fly  1149 VQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQWIARQMELHADKPPILLVAGTDDMQ 1213
             |.::||...:.......|::..     ||            .|::|....|....|..|..|.:
Mouse  1131 -QQVEEIGIEKAAMDMTVFLKLQ-----KR------------VRELEQERKKLQAQLEKGQQDSK 1177

  Fly  1214 MCELSLEETGLTRKRGAEILEHEFNREWERNGGKAYKN 1251
            ..::..:..||...:.|:|..:...|:...:..|..||
Mouse  1178 KGQVEQQNNGLDVDQDADIAYNSLKRQELESENKKLKN 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/46 (22%)
		MYSc_Myo6	71..754	CDD:276833	260/712 (37%)
		CBD_MYO6-like	765..913	CDD:409646	35/171 (20%)
		ERM_helical	<954..1020	CDD:466641	20/83 (24%)
		MYO6_MIU_linker	1002..1093	CDD:480843	23/94 (24%)
		MyUb_Myo6	1076..1116	CDD:439319	8/39 (21%)
		Myosin-VI_CBD	1160..1246	CDD:465157	14/85 (16%)
Myo5b	XP_006525777.1	COG5022	11..>1268	CDD:227355	392/1338 (29%)
		MYSc_Myo5	83..750	CDD:276831	260/712 (37%)
		EnvC	1202..>1441	CDD:443969	4/14 (29%)
		Myo5b_CBD	1475..1846	CDD:271261