Protein Alignment jar and Myo1f

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_444444.2
• Gene: Myo1f / 17916
• MGIID: 107711
• Length: 1098
• Species: Mus musculus
• Alignment Length: 1073
• Identity: 314/1073 - (29%)
• Similarity: 491/1073 - (45%)
• Gaps: 198/1073 - (18%)

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPD-TIKKYNGRSLGEL 123
            ||...|..:.|...:.||:.|:..|.|:||:.::||:|||::::.  |..| .|..|.|.:..|.
Mouse    20 DDMVLLPQITEDAIVSNLRKRFMDDYIFTYIGSVLISVNPFKQMP--YFTDREIDLYQGAAQYEN 82

  Fly   124 PPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY---SHDSAGPIETKILDA 185
            |||::|:.|...|:|.:...:|.:|:|||||||||.:.||::.|:..   ..|....::..||.:
Mouse    83 PPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGDKVQHVKDIILQS 147

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ||:|||||||||.||||||||||:.|:.:....:..||.||::||||||:..|:..|||:|::|.
Mouse   148 NPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQ 212

  Fly   251 LLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQH 315
            ||.||.|:.:..|.|..||.|.||:                   :|..::.:|      .||...
Mouse   213 LLEGASQEQQQNLGLMTPDYYYYLN-------------------QSDTYKVEG------TDDRSD 252

  Fly   316 FHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAF-EEIPDDVRGGCQVSEASEQSLTITSGLL 379
            |.....|:..:|:..:.:..:..|||.:||||||:| ||       |......|...|...:.||
Mouse   253 FSETLSAMQVIGIPTSVQQLVLQLVAGILHLGNISFCEE-------GNYARVESVDLLAFPAYLL 310

  Fly   380 GVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIP 444
            |:|...|:..|.||.|.||.|| :...|.|.|.:.:|:..||||||.:|:||||.:|..||:::.
Mouse   311 GIDSGRLQEKLTSRKMDSKWGG-RSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQ 374

  Fly   445 FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            .....:.||||||.|||.|..|.|||||||:.|||||:.|.:..||.|||.|.:||:....|.:.
Mouse   375 KPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYF 439

  Fly   510 DNQDIIELIEAKSN--GIFTLLD-------------EESKLPKPSYSHFTAEVHKSWANHYRLGL 559
            :|:.:.:|||.|.:  ||.::||             :::.|.|...:..|.|...||:
Mouse   440 NNKIVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWS------- 497

  Fly   560 PRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSG 624
                           .||::.|:||.|.|:...|.|:|.|.|.:.|..|:|..|...|:.|||..
Mouse   498 ---------------AGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQSSDQDFLRMLFPEK 547

  Fly   625 SSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGT 689
            .:...:|:.:  :.|||.|.|..:|:..|::...::|||||||.....|.:|.|....|::..|.
Mouse   548 LNIDKKGRPS--TAGSKIKKQANDLVSTLKKCTPHYIRCIKPNETKRPRDWEESRVKHQVEYLGL 610

  Fly   690 ISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLP-----ARTFCEAMFQSLNLSAKDFKFGIT 749
            ...:.:...|:..|..|:.....| ::|.||  :.|     .|...:.:.:::|:....::.|.|
Mouse   611 RENIRVRRAGFAYRRQFSKFLQRY-AILTPE--TWPRWRGDERQGVQHLLRAVNMEPDQYQMGST 672

  Fly   750 KVF------------FRPGKFVEFDRI----------------MRSDPENMLAIVAKVKKWLIRS 786
            |||            .|..||..|.|.                ||.:..|:|....:.::..|..
Mouse   673 KVFVKNPESLFLLEEMRERKFDGFARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINR 737

  Fly   787 RWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINK----IRTNTLK 847
            .:|...||    ::.|..:              |.|||:::.......:.|.::    |:.:.:.
Mouse   738 NFVGDYLG----LEERPEL--------------RQFLAKRERVDFADSVTKYDRRFKPIKRDLIL 784

  Fly   848 TIEIASGLKMGREEIISG-----VNDIYRQIDD--AIKKIKMNPR-----ITQRE-MDSMYTVVM 899
            |.:..  ..:|||::..|     |.::.::..|  |::.:.::.|     |.|.| .||....:.
Mouse   785 TPKCV--YVIGREKVKRGPEKGLVREVLKKKLDIQALRGVSLSTRQDDFFILQEEAADSFLESIF 847

  Fly   900 ANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRK 964
            .     |..::...|..::|..:.......:.|:. |..||.........:...|..:::...:.
Mouse   848 K-----TEFVSLLCKRFEEAARRPLPLTFSDLLQF-RVKKEGWGGGSTRNVTFSRGTSDLAVLKA 906

  Fly   965 AAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPP- 1028
            ..           |...:::.:.|.|..|...|...| .:.||..:...|.|        ..||
Mouse   907 GG-----------RALTISIGDGLPKSTKPTRKGLAQ-GRPRRSAQAPTRAA--------PGPPR 951

  Fly  1029 -VIRNGVNDAS------------------PMGP 1042
             :.||||..:|                  |.||
Mouse   952 GLNRNGVPPSSQVRSLPLEITSGRSSQRPPRGP 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	248/719 (34%)
		CBD_MYO6-like	765..913	CDD:409646	30/164 (18%)
		ERM_helical	<954..1020	CDD:466641	11/65 (17%)
		MYO6_MIU_linker	1002..1093	CDD:480843	14/61 (23%)
		MyUb_Myo6	1076..1116	CDD:439319
		Myosin-VI_CBD	1160..1246	CDD:465157
Myo1f	NP_444444.2	MYSc_Myo1	31..677	CDD:276829	248/707 (35%)
		Myosin_TH1	717..915	CDD:461801	37/234 (16%)
		PHA03247	<920..1043	CDD:223021	18/74 (24%)
		SH3_MyoIe_If_like	1045..1097	CDD:212761