Protein Alignment jar and Myo10

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_062345.2
• Gene: Myo10 / 17909
• MGIID: 107716
• Length: 2062
• Species: Mus musculus
• Alignment Length: 1165
• Identity: 353/1165 - (30%)
• Similarity: 551/1165 - (47%)
• Gaps: 218/1165 - (18%)

  Fly     8 VWVRD-----------AAEGYIQGRITEIGA----KEFEVTPTDRKYPKRTCHFDDIHSSCDGPQ 57
            ||:|:           .|||.:..: |:.|.    |:..:|      .::......:|.     :
Mouse    11 VWLRENGQHFPSTVNSCAEGVVVFQ-TDYGQVFTYKQSTIT------NQKVTAMHPLHE-----E 63

  Fly    58 DHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGE 122
            ..||...|..|:..:.:.||..||.:::||||:.:|:.:||||:.|..||...|:::|:...|||
Mouse    64 GVDDMASLAELHGGSIMYNLFQRYKRNQIYTYIGSIIASVNPYQPIAGLYERATMEEYSRCHLGE 128

  Fly   123 LPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY---------SHDSAGPI 178
            ||||:||||::..|.:.....:|.:::|||||||||||||.:||:|..         ..:....:
Mouse   129 LPPHIFAIANECYRCLWKRHDNQCVLISGESGAGKTESTKLILKFLSVISQQTLDLGLQEKTSSV 193

  Fly   179 ETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEER 243
            |..||.::|::||||||||..||||||||||::::...:..:.||.|..|||||:|:..|:..||
Mouse   194 EQAILQSSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQQGNIQGGRIVDYLLEKNRVVRQNPGER 258

  Fly   244 NYHVFYMLLAGAPQQLRDKLSLGKPDDYRYL--SGCTQYFANAKTEQLIPGSQKSKNHQQKGPLK 306
            |||:||.||||..|..|::..|..|::|.||  ||||:
Mouse   259 NYHIFYALLAGLDQGEREEFYLSLPENYHYLNQSGCTE--------------------------- 296

  Fly   307 DPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQS 371
            |..|.|.:.|..:..|:..:..|..|...:..|:|.:||||||.|     ...||.|:  ..:.:
Mouse   297 DKTISDQESFRQVITAMEVMQFSKEEVREVLRLLAGILHLGNIEF-----ITAGGAQI--PFKTA 354

  Fly   372 LTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIV 436
            |..::.|||:|.|:|..||..|.|.     .:|..|:.||.:.:|.::||:||.|:|:|.|:.::
Mouse   355 LGRSADLLGLDPTQLTDALTQRSMI-----LRGEEILTPLSVQQAVDSRDSLAMALYARCFEWVI 414

  Fly   437 GLINQSIPFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGL 501
            ..||..|..:.....||:|||.|||.|.||.||||.|||.|||||::||.:|...||..|.||||
Mouse   415 KKINSRIKGKDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGL 479

  Fly   502 NVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLK 566
            ...:|.:.||.:.::||| |..|:..|::|||..|:.:.|....::|...||::....||.:
Mouse   480 VWEDIDWIDNGECLDLIE-KKLGLLALINEESHFPQATDSTLLEKLHSQHANNHFYVKPRVA--- 540

  Fly   567 AHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRG 631
                   ...|.|:|:||.|.|:....:|||.|.....|..|::|.....:..||...||.:.:.
Mouse   541 -------VNNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNQD 598

  Fly   632 KLNFIS------VGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTI 690
            .|...|      |.|:||..|..||..|..:...|:||||||::.:..||:..:.|.||:.||.:
Mouse   599 TLKCGSKHRRPTVSSQFKDSLHSLMATLSSSNPFFVRCIKPNTQKMPDQFDQVVVLNQLRYSGML 663

  Fly   691 SVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLP--ARTFCEAMFQSLNLSAKDFKFGITKVFF 753
            ..:.:.:.||..|..|.|.|..||.::  ..::||  .|..|..:.|..:.|..:::.|.||||.
Mouse   664 ETVRIRKAGYAVRRPFQDFYKRYKVLM--RNLALPDDIRGKCTVLLQVYDASNSEWQLGKTKVFL 726

  Fly   754 RPGKFVEFDRIMRSDPENMLAIV-AKVKKWLIRSRWVKSALGALCVIK------LRNRIIYRNKC 811
            |.....:.::....:.:....:: |.:..:|.|.::.|...|.:.:.|      .|.:.::..|.
Mouse   727 RESLEQKLEKRREEEIDRAAMVIRAHILGYLARKQYRKVLCGVVTIQKNYRAFLARKKFLHLKKA 791

  Fly   812 VLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDA 876
            .::.|:..||.|||:                                          :|||:
Mouse   792 AIVFQKQLRGQLARR------------------------------------------VYRQL--- 811

  Fly   877 IKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEA 941
                    ...:||::.                ..:.:|:::.||:||        |.|||.:||
Mouse   812 --------LAEKRELEE----------------KKRREEEKKREEEER--------ERERAQREA 844

  Fly   942 EEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQE--QLEKEAKD--DAKYRQQL 1002
            :..|..:|.|.:| :.|:|..:|:.....|.:|.|.:|....::|  :||||.:|  ..|.||:|
Mouse   845 DLLRAHQEAETRR-QQELEALQKSQREADLTRELEKQRENKQVEEILRLEKEIEDLQRMKERQEL 908

  Fly  1003 E---------QERRDHEL------ALRLANE-----SNGQVEDSPPVIRNGVNDASPMGPNKLIS 1047
            .         |:.||.||      |.|.|.|     :..::::....|...::..|.:...:|..
Mouse   909 SLTEASLQKLQQLRDEELRRLEDEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEISGEELSE 973

  Fly  1048 FSQVVS------NIASRYLNK---SENVRAQQQALGKQKYDLSKWKYSELR-DAINTSCD 1097
            .::..|      |.:..|..:   .|...|...|. |...:.|:..:|:.| ..|.||.|
Mouse   974 LAESASGEKPNFNFSQPYPAEEEVDEGFEADDDAF-KDSPNPSEHGHSDQRTSGIRTSDD 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/55 (18%)
		MYSc_Myo6	71..754	CDD:276833	260/701 (37%)
		CBD_MYO6-like	765..913	CDD:409646	19/154 (12%)
		ERM_helical	<954..1020	CDD:466641	27/89 (30%)
		MYO6_MIU_linker	1002..1093	CDD:480843	23/120 (19%)
		MyUb_Myo6	1076..1116	CDD:439319	7/23 (30%)
		Myosin-VI_CBD	1160..1246	CDD:465157
Myo10	NP_062345.2	SH3_19	7..58	CDD:465815	10/53 (19%)
		MYSc_Myo10	77..727	CDD:276840	260/701 (37%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	619..641		10/21 (48%)
		DUF5401	<727..982	CDD:375164	65/332 (20%)
		SAH. /evidence=ECO:0000250|UniProtKB:Q9HD67	814..882		23/92 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..844		9/29 (31%)
		TPH	<840..946	CDD:464007	33/106 (31%)
		MYO10_CC	882..932	CDD:465249	15/49 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	963..1047		16/71 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1062..1089
		PH-like	1185..>1227	CDD:473070
		PH2_MyoX	1219..1320	CDD:270108
		PH3_MyoX-like	1385..1510	CDD:270109
		MyTH4	1553..1699	CDD:214535
		FERM_F1_Myosin-X	1701..1796	CDD:340726
		B41	1708..1962	CDD:214604
		FERM_C_MyoX	1958..2046	CDD:270023