Protein Alignment jar and hum-8

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001294574.1
• Gene: hum-8 / 176872
• WormBaseID: WBGene00002041
• Length: 1279
• Species: Caenorhabditis elegans
• Alignment Length: 1274
• Identity: 548/1274 - (43%)
• Similarity: 776/1274 - (60%)
• Gaps: 117/1274 - (9%)

  Fly     8 VWVRDAAEGYIQGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQDH-DDNCELMLLNEA 71
            ||:.||.:|:...||.::.|..|.:...|......|..|:|:.:..|..:.| :|||:||.||||
 Worm    79 VWITDATDGFRAARIIDLSATGFTLRLLDNTGDTVTRVFEDVLACEDDSRRHVEDNCQLMHLNEA 143

  Fly    72 TFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAIR 136
            |.|:|::.||...|||:|||||||::|||:.|...|:...||:|.|:|||:..||:||||||:.|
 Worm   144 TLLNNIRLRYQNGKIYSYVANILISINPYQTIDGFYSLQKIKEYRGKSLGQKEPHIFAIADKSYR 208

  Fly   137 DMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDS-AGPIETKILDANPVLEAFGNAKTTRN 200
            :|..::.|||||||||||||||||.|.:|:|||.:..| ||.|:.::|:.||:|||||||||.||
 Worm   209 EMIRHRKSQSIIVSGESGAGKTESQKAVLRYLCENWGSGAGEIQKRLLETNPILEAFGNAKTLRN 273

  Fly   201 NNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDKLSL 265
            |||||||||:::|:.....|.|||:||||||.||||.|:|.|||||:||.|:||:..:|...|:|
 Worm   274 NNSSRFGKFVQIHFADTGNVAGGYVSHYLLETSRICRQAAGERNYHIFYQLIAGSSPELFKFLAL 338

  Fly   266 GKPDDYRYLS-GCTQYFA--NAKTEQLIPGSQKSKNHQQKGPLKDP------IIDDYQHFHNLDK 321
            |:|:.:.||. |...:|.  ::.|...||          |..|.||      ::||:..|..|:.
 Worm   339 GQPNQFNYLKRGFIGFFTHPSSGTTSKIP----------KNRLSDPKFTQDSMVDDFSDFQRLEY 393

  Fly   322 ALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTEL 386
            ||...|||:.|...|::.:||:|||||:.|||..||.||||:|...|||.|...:.|||::..||
 Worm   394 ALKLTGLSEQEIHFIWTTIAAILHLGNVEFEESLDDSRGGCKVFNGSEQDLIQAARLLGLETMEL 458

  Fly   387 RTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQASNFY 451
            :..|.:|:||:..||.:||:|.||||.:||.:.||||:|||||:|||.:|..||.||||:.|..:
 Worm   459 KMGLCARIMQTTKGGARGTLIRVPLKPHEACSGRDALSKAIYSKLFDWLVSRINDSIPFEKSTNF 523

  Fly   452 IGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIE 516
            :||||:||||::..|||||||||:||||||.|||..||:.|||||::|||||.:|.|.||||.||
 Worm   524 VGVLDVAGFEFYAKNSFEQFCINFCNEKLQNFFNQRILREEQELYEKEGLNVRKIEFIDNQDCIE 588

  Fly   517 LIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRH 581
            |.|.|.||:|.|||||:|.|..:|..||...|:....|:||..||.|::|:||.|||:||.|:||
 Worm   589 LFELKGNGLFDLLDEEAKFPTSNYKSFTKRAHEENRKHFRLDTPRKSKVKSHRELRDDEGLLIRH 653

  Fly   582 FAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNFISVGSKFKTQL 646
            :||:|||.|:.|:|||:|.||.||:.|:::....||.:||.| ::...:.||..:|||:|||.||
 Worm   654 YAGSVCYETKHFVEKNDDLLHNSLQILIEQSTIRLLVSLFGS-TAYPTKSKLKALSVGAKFKNQL 717

  Fly   647 GELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYS 711
            ..|:.|||..||:|:||||||::||..:|:||..|:||:|:|..|||:||:.|:|||..|.|||:
 Worm   718 STLLIKLESTGTHFVRCIKPNNQMIPFEFDGSAILSQLQCAGMTSVLKLMQDGFPSRTGFGDLYA 782

  Fly   712 MYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIV 776
            .|:..|||:|..|..|.||:.:|::|.|...||:||:||||||.|||.|||::|:.|||.|.:::
 Worm   783 CYQKKLPPKLSKLDPRMFCKCLFRALGLDQHDFQFGLTKVFFRAGKFAEFDQMMKQDPETMTSLI 847

  Fly   777 AKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKI 841
            .||.:||:.:||.:|......||||:|:|.:|:..|...|.||||:|.|::...:.....|...:
 Worm   848 QKVNEWLVGARWKQSQYAVWSVIKLKNKIAWRSAQVTRLQSIARGYLTRQRFSRQIALYRKSVAL 912

  Fly   842 RTNTLKTIEIASGL-KMGREEIISGVNDIYRQIDDAIKKIKMNPRITQ--REMDSMYTVVMANMN 903
            ..|:.:..:|...| :..|.:..|..:...|.::..:..||:......  .:.::.|...:..::
 Worm   913 LKNSKEIEKILFRLNEHSRAKYTSSAHSTIRDLEKLVSHIKLTTSANDHFEKAENAYEHYVKRVD 977

  Fly   904 KLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIE-NKRLKAEMETRRKAAE 967
            .:..|    ||:||:::         |..|.||..:|:|| ::|.||| .|..:.:.|.:||..|
 Worm   978 SMIAD----LKKQQKSD---------ELAEIERKRRESEE-KERLEIEAKKEAERQREIKRKLEE 1028

  Fly   968 AQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNG--------QVE 1024
            .|:..|:|.:.    .|..::.|.|::..|.||..|:|:.|..::.||| |::|        ::|
 Worm  1029 QQQNAQKEHEN----YLISEIHKAAEETEKKRQNEEKEKLDKMVSNRLA-EADGVALISSKMEIE 1088

  Fly  1025 DS--PPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLSKWKYSE 1087
            .|  ....|:|                                           |||:....::.
 Worm  1089 PSSGSATFRDG-------------------------------------------KYDVGGCSFAY 1110

  Fly  1088 LRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAP-RSVMEAAFKQPPLVQP 1151
            |||.||||.||.||:||.:||.|||::|:.||::|     ....:|.| |:.:....::..:::.
 Worm  1111 LRDTINTSMDINLLKACEEEFRRRLRIYNEWKSRN-----APVQDRPPARAALSTVCEELSIMRS 1170

  Fly  1152 IQEIVTAQ-HRYFRIPFMRAN------------APDNTKRGLWYAHFDGQWIARQMELHADKPPI 1203
            |......| .|||:..|...|            ..|..:..:|:.||.||.|.||:...:.:||.
 Worm  1171 IATPSAPQIQRYFKCEFKENNQKGTCSWGSSIKCEDLDQVSMWFVHFSGQQIQRQLTFTSSRPPQ 1235

  Fly  1204 LLVAGTDDMQMCELSLEETGLTRKRGAEILEHEFNREWE 1242
            .|:||.||.|||.|:|:||.|..||||||.|.||...|:
 Worm  1236 TLIAGRDDAQMCTLALQETLLVGKRGAEISEDEFESHWK 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	12/40 (30%)
		MYSc_Myo6	71..754	CDD:276833	369/692 (53%)
		CBD_MYO6-like	765..913	CDD:409646	38/150 (25%)
		ERM_helical	<954..1020	CDD:466641	20/65 (31%)
		MYO6_MIU_linker	1002..1093	CDD:480843	18/100 (18%)
		MyUb_Myo6	1076..1116	CDD:439319	21/39 (54%)
		Myosin-VI_CBD	1160..1246	CDD:465157	39/95 (41%)
hum-8	NP_001294574.1	MYSc_Myo6	143..825	CDD:276833	369/692 (53%)
		CBD_MYO6-like	836..987	CDD:409646	40/154 (26%)
		tolA_full	983..>1076	CDD:274303	36/107 (34%)
		MyUb_Myo6	1099..1139	CDD:439319	22/82 (27%)
		Myosin-VI_CBD	1180..1276	CDD:465157	39/95 (41%)