Protein Alignment jar and nmy-2

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_492186.3
• Gene: nmy-2 / 172562
• WormBaseID: WBGene00003777
• Length: 2003
• Species: Caenorhabditis elegans
• Alignment Length: 1340
• Identity: 379/1340 - (28%)
• Similarity: 593/1340 - (44%)
• Gaps: 302/1340 - (22%)

  Fly     6 QLVWVRDAAEGYIQGRIT----EIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQDHD-DNCE- 64
            :|:||....:|:..|.:.    ..|..:.|:..|..   ::....||    |..|.... |.||
 Worm    33 KLMWVPSEKDGFALGAVIGEPHADGTIDIELMETGE---RQRVSSDD----CQKPNPPKYDKCED 90

  Fly    65 ---LMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPH 126
               |..||||:.|.|||.||:.:..|||.....:.:|||:.| .:|.....:::..:...|:|||
 Worm    91 MSMLTCLNEASVLHNLKQRYFSNLYYTYSGLFCVVINPYKRI-PIYTDTIAEQFKCKKRKEMPPH 154

  Fly   127 VFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY-------------------SH 172
            :||:||:|.|.|...:..|||:.:|||||||||:||.:::||.|                   ::
 Worm   155 IFAVADEAYRSMLQERDDQSILCTGESGAGKTENTKKVIQYLAYVANRSMVKNRKTSVDLDTSTN 219

  Fly   173 DSAGPIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICT 237
            ...|.:|.::|.|||:||||||:||.:|:|||||||||.||:|:...:.|..|..|||||||:..
 Worm   220 RIMGQLEEQLLQANPILEAFGNSKTVKNDNSSRFGKFIRVHFDSTGCISGANIEFYLLEKSRVLK 284

  Fly   238 QSAEERNYHVFYMLLAGAPQQLRDKL----SLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKN 298
            |:..||::|:||.||.|..:..|:..    ||.|   |:::|
 Worm   285 QAPNERSFHIFYQLLKGLSKVQREHYLLEDSLSK---YKFVS----------------------- 323

  Fly   299 HQQKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQ 363
               .|..|...:||.........|:..:||:|.|..||..:|:||:..||:.|.....:......
 Worm   324 ---NGDSKLAGVDDGAEMKETLNAMSIMGLNDEEIGGILRVVSAVMLFGNLEFSHENKNNDQAVL 385

  Fly   364 VSEASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARD------- 421
            :::|..|.:   :.||||:.|||..|            |....|.|...:...:.:.|
 Worm   386 LNDAVAQKI---ASLLGVNVTELMRA------------FLKPKIKVQRDLVHRAQSVDQVNFSVG 435

  Fly   422 ALAKAIYSRLFDRIVGLINQSI--PFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFF 484
            |:|||.|.|||..:|..:|:|:  ..|.|..:||:|||||||.|..|||||.||||.|||||:.|
 Worm   436 AIAKASYERLFRWLVHRLNKSLDRTRQQSVSFIGILDIAGFEIFETNSFEQLCINYTNEKLQQLF 500

  Fly   485 NDNILKNEQELYKREGLNVPEITFTDN-QDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVH 548
            |:.:...||:.|..|||....:.|..| |..|:||: |..||.:.||:....|:.:...|...::
 Worm   501 NNTMFVREQQEYLDEGLEWKFLDFGLNLQPTIDLID-KPMGIMSTLDDVCLFPQGNDQSFVQRLN 564

  Fly   549 KSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECD 613
            .:.:.|.:..:|.         :|....|.|.|:||.|.|.:|.:..||.|.|:.::..:::...
 Worm   565 NTHSQHPKYVVPE---------IRSRSDFAVVHYAGRVDYQSEGWRVKNMDPLNENVIDVLKTSK 620

  Fly   614 NPLLQTLF------------PSGSSTSVRG-----KLNFISVGSKFKTQLGELMEKLEQNGTNFI 661
            ..|:..::            .|.|.|.|.|     |..|.:|...:|.||..||..|.....:|:
 Worm   621 ESLIVDMWKDIADVCSLSAADSTSDTGVFGSRVPKKGMFRTVSQLYKEQLARLMSTLNNTNPHFV 685

  Fly   662 RCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVS--- 723
            |||.||.:.........|.|.||:|:|.:..:.:...|:|:|:.|.:....|:.:|.|::..
 Worm   686 RCIIPNHEKKHGVLNAHLVLDQLRCNGVLEGIRICRQGFPTRLPFQEFRQRYEKLLAPDVNPAGF 750

  Fly   724 LPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIV----AKVKKWL- 783
            :..:.....:.|.|.:.|..|:.|.:|:|||.|...||:. ||.  :.:.|::    |:.:.||
 Worm   751 MDGKNAVYRIVQYLEVDANLFRIGQSKIFFRSGVIAEFEE-MRD--QKLSALIESFQAQCRGWLG 812

  Fly   784 ----IRSRWVKSAL-----GALCVIKLRN----RIIYR--------NKCVLIAQRIAR-GFLARK 826
                :|.|..:.|:     ..|..::||.    |::.:        ||..|||:|... ...|.|
 Worm   813 RRVMVRRREQEVAIKILQRNGLAWMRLREWQWWRLLTKVKPLLEVTNKDELIAEREQELKVTAEK 877

  Fly   827 QHRPRY------QGIGKINKIRTNTLKT------------IEIASGLKMGREEIISGVNDIYRQI 873
            ..|...      |.:.|:::.|. .|||            .|..|.:...|:|:...:.::.:::
 Worm   878 LRRSEVFISDYKQQMEKMDEERL-VLKTRLDAESSERAEIFEERSRMAARRDELEGILEEVSKRL 941

  Fly   874 DDAIKKIKM----NPRITQ--REMDSMYTVVMANMNKLTVDLN---TKLKE-QQQAEEQE----R 924
            :...:|.|.    :.::|:  |.::........:..||.::.|   ::||| :.|..|.|    :
 Worm   942 EIEEQKAKKADSESRKLTEMVRHLEENLEDEERSRQKLLLEKNSIESRLKELEAQGLELEDSGNK 1006

  Fly   925 LRKIQEALE------AERAAKEAEEQRQ---------------REEIE-NKRLKAEMETRRKAAE 967
            |.|.::|||      :.|...|.|..:|               .:|:| .|:.:...||.|:|||
 Worm  1007 LSKEKKALEERCEDLSSRLIDEVERSKQLVKAKARLEATVAEINDELEKEKQQRHNAETARRAAE 1071

  Fly   968 AQRLRQEEED-----RRA-----------------------ALALQEQLEKEAK------DDA-- 996
            .| ||:|:|.     |:|                       .||.::|||:|.:      |||
 Worm  1072 TQ-LREEQESCLEKTRKAEELTNQLMRKESELSQISIRNDEELAARQQLEREIREIRAQLDDAIE 1135

  Fly   997 ------KYRQQLEQERRDHELALRLANESNG---QVEDSPPVIRNGVNDASPMGPNKLISFSQVV 1052
                  ..||:.|:.|||      :|.|...   ::|:|        ||       |.:..||:.
 Worm  1136 ETNKEKAARQKAEKARRD------MAEELESYKQELEES--------ND-------KTVLHSQLK 1179

  Fly  1053 SNIASRYLN---------KS-----ENVRAQQQ-----------ALGKQKYDLSKWKYSELRDAI 1092
            :.....|.:         ||     |.::||.|           .|.:||....|.|.|...|..
 Worm  1180 AKRDEEYAHLQKQLEETVKSSEEVVEEMKAQNQKKIEELNETIDQLKRQKISADKAKSSAESDNE 1244

  Fly  1093 NTSCDIELLEACRQEFHRRLKVYH-AWKAKNRKRTTMDEN 1131
            |...::..:.:.|.|..::.|... :...|:.|...|..|
 Worm  1245 NFRAELSNIASARLEAEKKRKAAETSLMEKDHKMREMQSN 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	9/45 (20%)
		MYSc_Myo6	71..754	CDD:276833	239/735 (33%)
		CBD_MYO6-like	765..913	CDD:409646	39/201 (19%)
		ERM_helical	<954..1020	CDD:466641	30/107 (28%)
		MYO6_MIU_linker	1002..1093	CDD:480843	27/118 (23%)
		MyUb_Myo6	1076..1116	CDD:439319	10/39 (26%)
		Myosin-VI_CBD	1160..1246	CDD:465157
nmy-2	NP_492186.3	MYSc_class_II	100..781	CDD:276951	239/735 (33%)
		Myosin_tail_1	858..1934	CDD:460256	103/450 (23%)