Protein Alignment jar and myo-1

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_492053.1
• Gene: myo-1 / 172471
• WormBaseID: WBGene00002348
• Length: 1938
• Species: Caenorhabditis elegans
• Alignment Length: 1537
• Identity: 403/1537 - (26%)
• Similarity: 648/1537 - (42%)
• Gaps: 385/1537 - (25%)

  Fly     8 VWVRDAAEGYIQGRITEIGAKEFEVTPT----DRKYPKRTCHFDDIHSSCDGP--QDHDDNCELM 66
            ||:.||.||||:|.|...|.|...|..|    |....|      ||....:.|  :..:|...|.
 Worm    35 VWIPDAEEGYIEGVIKGPGPKADTVIVTAGGKDVTLKK------DIVQEVNPPKFEKTEDMSNLT 93

  Fly    67 LLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIA 131
            .||:|:.|.||::||....||||.....:.:|||:.: .:|.....:.:.|:...|:|||:||::
 Worm    94 FLNDASVLWNLRSRYAAMLIYTYSGLFCVVINPYKRL-PIYTDSVARMFMGKRRTEMPPHLFAVS 157

  Fly   132 DKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY-------------SHDSAGPIETKIL 183
            |:|.|.|.....:||::::|||||||||:||   |.:||             ..:....:|.:|:
 Worm   158 DQAYRYMLQDHENQSMLITGESGAGKTENTK---KVICYFATVGASQKAALKEGEKEVTLEDQIV 219

  Fly   184 DANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVF 248
            ..||||||||||||.||||||||||||.:|::....:....|.||||||||:..|:..||.||:|
 Worm   220 QTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGTLASCDIEHYLLEKSRVIRQAPGERCYHIF 284

  Fly   249 YMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDY 313
            |.:.:....||||:|.|..|        .:.|:..|:.|.||.|                 |||.
 Worm   285 YQIYSDFKPQLRDELLLNHP--------ISNYWFVAQAELLIDG-----------------IDDT 324

  Fly   314 QHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGL 378
            :.|...|:|...|..|.|||:..|.|::|.:|:||:.|::.|.:.:......:.:|::    ..:
 Worm   325 EEFQLTDEAFDVLKFSPTEKMDCYRLMSAHMHMGNMKFKQRPREEQAEPDGQDEAERA----CNM 385

  Fly   379 LGVDQTELRTALVS-RVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQS 442
            .|:|..:...|||| ||........||.      .:.:...|..|:||.:|:|:|..:|...|.:
 Worm   386 YGIDVDQFLKALVSPRVKVGTEWVSKGQ------NVDQVHWAIGAMAKGLYARVFHWLVKKCNLT 444

  Fly   443 IPFQA--SNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPE 505
            :..:.  .:::||||||||||.|..|||||..||:.|||||:|||.::...|||.|.|||:....
 Worm   445 LDQKGIDRDYFIGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTF 509

  Fly   506 ITF-TDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGL-PRSSRLKAH 568
            |.| .|.|..||||| |..||.::||||..:||.:......::     ....||. |...:.|..
 Worm   510 IDFGLDLQACIELIE-KPLGIISMLDEECIVPKATDMTLAQKL-----TDQHLGKHPNFEKPKPP 568

  Fly   569 RTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQEC-DNPLLQTL---FPSGSSTSV 629
            :..:.|..|.:||:||.|.||...::|||.|.|:.::..:::.. .|.||..:   :.:....:.
 Worm   569 KGKQGEAHFAMRHYAGTVRYNVLNWLEKNKDPLNDTVVSVMKASKKNDLLVEIWQDYTTQEEAAA 633

  Fly   630 RGKL----------NFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQL 684
            ..|.          :|::|...::..|.:||..|.:...:|||||.||.|......:.:|.|.||
 Worm   634 AAKAGGGRKGGKSGSFMTVSMMYRESLNKLMTMLHKTHPHFIRCIIPNEKKQSGMIDAALVLNQL 698

  Fly   685 KCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFC-----EAMFQSLNLSAKDF 744
            .|:|.:..:.:...|:|:|....|....|..:...|..|......|     :|:.....|:.:.|
 Worm   699 TCNGVLEGIRICRKGFPNRTQHPDFVQRYAILAAKEAKSSDDMKTCAGAILQALINQKQLNDEQF 763

  Fly   745 KFGITKVFFRPGKFVEFDRIMRSDPENML------------------AIVAKVKKWLIRSRWVKS 791
            :.|.|||||:.|.....:. :|.|..|.:                  |...::..::|..|.::|
 Worm   764 RIGHTKVFFKAGVVAHIED-LRDDKLNQIITGFQSAIRWYTATADAGARRKQLNSYIILQRNIRS 827

  Fly   792 ALGALCVI----------KLRNRIIYRNKCVLIAQRI-----------ARGFLARKQHRPRYQGI 835
                .||:          |||.::    ||..:|:.:           |....|....:.:.:..
 Worm   828 ----WCVLRTWDWFLLFGKLRPQL----KCGKMAEEMIKMAEEQKVLEAEAKKAESARKSQEEAY 884

  Fly   836 GKINKIRTNTLKTIEIASG-----------LKMGREEIISGVNDIYRQIDDAIKK---IKMNPRI 886
            .|::..|:..|:.:|:..|           |...|:|:...:||...::.:..:|   ::...|.
 Worm   885 AKLSAERSKLLEALELTQGGSAAIEEKLTRLNSARQEVEKSLNDANDRLSEHEEKNADLEKQRRK 949

  Fly   887 TQREMDSMYTVVMA------------------------NMN-------------KLTVDLNTKLK 914
            .|:|::::...:.|                        .||             ||..:.|.:|.
 Worm   950 AQQEVENLKKSIEAVDGNLAKSLEEKAAKENQIHSLQDEMNSQDETIGKINKEKKLLEENNRQLV 1014

  Fly   915 EQQQAEE-------------QERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMET----- 961
            :..||||             ::.|.:::||:|.|:..: ||.::.:.::|.: ||...||
 Worm  1015 DDLQAEEAKQAQANRLRGKLEQTLDEMEEAVEREKRIR-AETEKSKRKVEGE-LKGAQETIDELS 1077

  Fly   962 ----------RRKAAE--------------AQRL-RQEEEDRRAALALQEQLEKEAKDDAKY-RQ 1000
                      ::|.|:              |.|| ||.:|:.:..:.::::||.|.:..:|. |.
 Worm  1078 AIKLETDASLKKKEADIHALGVRIEDEQALANRLTRQSKENAQRIIEIEDELEHERQSRSKADRA 1142

  Fly  1001 QLEQERRDHELALRLANESNGQV----------------------------EDSPPVIRNGVNDA 1037
            :.|.:|...||..|| :|.|.|:                            ||...:||...||.
 Worm  1143 RAELQRELDELNERL-DEQNKQLEIQQDNNKKKDSEIIKFRRDLDEKNMANEDQMAMIRRKNNDQ 1206

  Fly  1038 SPMGPNKLISFSQVVSNI-------------ASRYLNKSENVRAQQQALGKQKYDLSKWKYSELR 1089
            .....|.|.:..:..:.|             .:..:::....|.:|:.|.|| |::   :.:||:
 Worm  1207 ISALTNTLDALQKSKAKIEKEKGVLQKELDDINAQVDQETKSRVEQERLAKQ-YEI---QVAELQ 1267

  Fly  1090 DAINTSCDIELLEACRQEFHRRLKVYHAWKAK----------------------NRKRTTMD--- 1129
            ..::             |..|::..|.:.|.:                      ||.:|...
 Worm  1268 QKVD-------------EQSRQIGEYTSTKGRLSNDNSDLARQVEELEIHLATINRAKTAFSSQL 1319

  Fly  1130 -------ENERAPRSVMEAAFK--QPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGL----- 1180
                   |:|...|....||.|  :..|.| ..|::..|          .|..|:.:|.|
 Worm  1320 VEAKKAAEDELHERQEFHAACKNLEHELDQ-CHELLEEQ----------INGKDDIQRQLSRINS 1373

  Fly  1181 ----WYAHFDGQWIARQMELH--------------------------ADKPPILLVAGTDDMQMC 1215
                |.|.::|:.:....||.                          .:|....|:|.|:|.:
 Worm  1374 EISQWKARYEGEGLVGSEELEELKRKQMNRVMDLQEALSAAQNKVISLEKAKGKLLAETEDAR-- 1436

  Fly  1216 ELSLEETGLTRKRGAEILEHEFNR---EWERNGGKAYKNLGA 1254
              |..:..||.....|..:..|::   :|:|......|.:.|
 Worm  1437 --SDVDRHLTVIASLEKKQRAFDKIVDDWKRKVDDIQKEIDA 1476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	16/44 (36%)
		MYSc_Myo6	71..754	CDD:276833	245/719 (34%)
		CBD_MYO6-like	765..913	CDD:409646	37/237 (16%)
		ERM_helical	<954..1020	CDD:466641	24/96 (25%)
		MYO6_MIU_linker	1002..1093	CDD:480843	26/131 (20%)
		MyUb_Myo6	1076..1116	CDD:439319	6/39 (15%)
		Myosin-VI_CBD	1160..1246	CDD:465157	21/123 (17%)
myo-1	NP_492053.1	Myosin_N	30..73	CDD:460670	16/43 (37%)
		MYSc_class_II	98..773	CDD:276951	245/719 (34%)
		Myosin_tail_1	854..1919	CDD:460256	118/658 (18%)