back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and hum-7

DIOPT Version :10

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001248880.1	Gene:	hum-7 / 171650	WormBaseID:	WBGene00002040	Length:	1880	Species:	Caenorhabditis elegans

Alignment Length:	1324	Identity:	338/1324 - (25%)
Similarity:	542/1324 - (40%)	Gaps:	321/1324 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DIHSSCDG--------PQDHD--DNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYRE 102
            ::.||.|.        |||.:  |.|.|..|.|.|.||||:.|:....||||:..||:||||:.
Worm   148 EVASSIDAFLTKFLVQPQDREYADLCNLPELTEQTLLDNLRERFANGHIYTYIGPILVAVNPFC- 211

  Fly   103 IKELYAPDTIKKY-NGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLK 166
            ...:|.|...:.| ..:.||.||||:|||||....:|...|.:|.:::|||||:||||||.:|:.
Worm   212 FFPIYNPKYARLYFQSKRLGSLPPHIFAIADVCYHNMLRIKENQCVVISGESGSGKTESTNHLMS 276

  Fly   167 YL--CYSHDSAG-PIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHY 228
            :|  .....|.| ..|..:|.|.|||||||||.|..|||||||||||:::|.....|.|..:..|
Worm   277 HLISLSQKGSTGCSTEQTLLSAGPVLEAFGNAVTLTNNNSSRFGKFIKINYRENGMVSGANVEIY 341

  Fly   229 LLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGS 293
            |||||||..|:..||||||||.||.||.::.|.|..|.||.||:||:
Worm   342 LLEKSRIIFQTKGERNYHVFYYLLEGADEEERKKYFLLKPHDYKYLN------------------ 388

  Fly   294 QKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDV 358
                   |..|.....:::...|..|..|:..:|.....:..|:.:::|||.||||.:.:
Worm   389 -------QNEPFALEGVNERNEFDRLRHAMSSVGFCAKTQQTIFGIISAVLLLGNITYIK----- 441

  Fly   359 RGGCQVSEA----SEQSLTITSGLLGVDQTELRTALVSR--VMQSKGGGFKGTVIMVPLKIYEAS 417
            |.|....|:    :|:.:.:.:.||.:....|..||..:  ||:::       .:::...:.||:
Worm   442 RHGYHSDESGYIENEEVVDLVANLLHIKTDTLMQALTMKRHVMKTE-------TVVLRYSVSEAT 499

  Fly   418 NARDALAKAIYSRLFDRIVGLINQSI---PFQA-SNFYIGVLDIAGFEYF--TVNSFEQFCINYC 476
            |.|||:||.||:.||..||..|||::   .|.| ..:|||:|||.|||..  ..|||||.||||.
Worm   500 NTRDAMAKCIYNSLFHYIVLRINQALLKKDFSAGKGYYIGILDIFGFEDVGSQCNSFEQLCINYA 564

  Fly   477 NEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYS 541
            |||||.:||.:|.:.|||.|.:||::...|.:|||.:.::|.::|..||..|:||||.:...:..
Worm   565 NEKLQSYFNQHIFQFEQEEYLKEGISWTNIEYTDNTECVQLFQSKPYGILRLVDEESNINNGTDD 629

  Fly   542 HFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNND------- 599
            ...|::::...|:.....|:          :.|..|:|.|:||.|.|....|.|||.|
Worm   630 SMLAKLNQFLKNNEYYETPQ----------KKEPAFIVAHYAGKVKYQITGFREKNKDLMRQDVL 684

  Fly   600 ----------------------------------------------------------------- 599

Worm   685 NALKSSTSSVMKTLLGIDPVAVHRWNVLRSVFRAMNAFKQSTRKLQKSESAGHLRVMDSIVTSPR 749

  Fly   600 -----ALHASLEG-----LVQECDNPLLQTL------FPSGSSTSVRGKLNFI------------ 636
                 ||.|.|.|     :...||..:..|:      .|:|.|......|..:
Worm   750 RGSDSALSAFLRGELRCEVPDFCDTSMFNTIRNQARRTPAGKSDDKMSLLKSLQILKEAIGGRRL 814

  Fly   637 -----SVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELM 696
                 ||..:|:..|..||..|......||||||.|:..|...|:.::.|.||:.:|.:..:.:.
Worm   815 AKKPSSVSKQFEYSLTRLMSTLANATPYFIRCIKSNNDKIANHFDDNIILRQLRYTGMLETVRIR 879

  Fly   697 EHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPG-KFVE 760
            ..||..|:.:......|:.:|.....| ......|.:....::...:.::|..|:|.|.. |.:.
Worm   880 RAGYSVRIEYPSFVQQYRILLRNGRDS-TVDDVKEYIHSHASIDNDNIQYGTNKIFMRDAEKLIL 943

  Fly   761 FDRIMRSDPENMLAIVAKVKKW----LIRSRWV-----------------------KSALGALCV 798
            .|.:.|:    ::..:..:::|    |.|.|::                       |.||.|..:
Worm   944 DDHLHRT----IMQSIDTLQRWFRTMLARKRYLRMKEGIIKIQALIRGSFARAEVRKKALAAQTI 1004

  Fly   799 ------IKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKIN---------KIRTNTLKT 848
                  .|.|.:.:...:.|:..|...||...||:.....:|.|.:|         |:....|..
Worm  1005 QCNWKKYKQRQKYLSIRESVIALQSAYRGASVRKRVGEIPKGNGALNVKKSPFRVRKVHAVNLTK 1069

  Fly   849 IEIASGLKM------------------GREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMY 895
            .:::....:                  |.::.||..:|.: |.|||:            ::|:.:
Worm  1070 FDLSDPSSLAAFALSDDDSDSDKSTQDGLDDDISEESDAF-QDDDAV------------DVDATF 1121

  Fly   896 TVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLK---- 956
            .:.           :||||..:.|:.....|   ::|....:..:.:..|:....|:....
Worm  1122 ILE-----------DTKLKLIEGADLSHHRR---QSLAPTASTTKLKMLRRANSTESNNFSMSRC 1172

  Fly   957 ------AEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQE---RRDHELA 1012
                  :...:::|....:...|:.:....||..:.:.|.|......:..:|..:   .:||:..
Worm  1173 DDSFTLSPTHSKKKGGAGKLGFQKAKKNLKALFGRNEDEDEPSPGPSFASELTPDVFVAKDHQFK 1237

  Fly  1013 L---------RLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRA 1068
            :         .|.|..          :.|.::.|......|:....:.....:|...|.:..||:
Worm  1238 MSRLHRQEICALCNRH----------LTNFISQAHKCQRCKMCLHKECFVFASSIPCNPTSPVRS 1292

  Fly  1069 QQQALG-KQKYDLSKWKYSELRDAINTSCDIELLEACRQ-----------EFHRRLKVYHAWKAK 1121
            ..:... |:.:||...|..:....|.::....|.:..:|           :..|:..::...|.:
Worm  1293 PTRLHSPKRPWDLMPHKQRQSSSPIPSTGTFSLTKTKQQIDPGNMLVESTDDLRQFSIFIFNKTR 1357

  Fly  1122 NRKRTTMDENERAPRSVMEAAFKQ 1145
            :     ::|:.....:|::|.||:
Worm  1358 H-----LNESNAKRDTVVDAVFKK 1376

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.