Protein Alignment jar and ninaC

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_318814.5
• Gene: ninaC / 1279139
• VectorBaseID: AGAMI1_013120
• Length: 1581
• Species: Anopheles gambiae
• Alignment Length: 1195
• Identity: 268/1195 - (22%)
• Similarity: 457/1195 - (38%)
• Gaps: 272/1195 - (22%)

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELP 124
            :|...|..|:|.|.|:.:..||.....||:|.::||::||...|.| |......||..:|..:..
Mosquito   336 EDLAALEQLSEETILEEITQRYKNGNTYTFVGDVLISLNPNETIPE-YVRGFHSKYMFKSRSDNA 399

  Fly   125 PHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKILDANPVL 189
            ||||||||.|.:||..::..|.||::|||.:|||.:.|.|:|:|....:....:..:|::....|
Mosquito   400 PHVFAIADSAYQDMLHHEEPQHIILAGESYSGKTTNLKLLMKHLGVLGEGNPGVYERIVNGYKAL 464

  Fly   190 EAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYML--L 252
            .|..||.|..|.||:|.....::.:.:..::.|.....|||||.||.:.:..:.|:|:||..  .
Mosquito   465 SALTNAGTPLNPNSTRSIVQAQLTFGSTGKLSGAIFWVYLLEKLRISSTNMNQSNFHIFYYFYDT 529

  Fly   253 AGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLK---DPIIDDYQ 314
            ..|.::|.| .||....:||||             ::..|....|       ||   |.|:.:.:
Mosquito   530 MDAEERLLD-FSLEGGRNYRYL-------------RISDGMSSDK-------LKYCRDDIVGNVR 573

  Fly   315 HFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLL 379
            .|...::.|..|.:|......||..:||:|.||.:.|:|     ..|....|:.|....|.: ||
Mosquito   574 AFKEFEEQLLALEISQDILETIYRTLAAILLLGEVRFKE-----TDGMTELESFEVISKIAT-LL 632

  Fly   380 GVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIP 444
            .:|:.:.:.||::..:..:|...:..     ....||.:|||.||..|||||.|.|...|||.:.
Mosquito   633 QLDEKKFQWALLNYCVIVRGSAERRR-----HTADEARDARDVLAATIYSRLVDWITNTINQKLA 692

  Fly   445 F----QASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPE 505
            |    ......:.|.|..|||.|..|..:|..:|..||::|..:|..|...|....:.|.:.|..
Mosquito   693 FGRAIYGDKHSVTVTDHFGFECFHRNHIDQLVVNALNEQMQYLYNQRIFVFEMIEMEEEQVPVTP 757

  Fly   506 ITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRT 570
            :.:.||:..::.|..|..|:|:.:|:.|: .:...::....:|.:.:       |...|...|.
Mosquito   758 LHYYDNKLAVDHILTKPKGVFSFIDDASR-GRHGQNYIIDSIHTNKS-------PFIKRASGHE- 813

  Fly   571 LRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFP-----SGSST--- 627
                  |.|.|:.|.:.|:.....:||.|.:...:...::....|:::.:|.     :|:.|
Mosquito   814 ------FTVAHYTGRITYDARDMPDKNRDFIPPEMVETLRASGEPIIKIMFSNQLSRTGNLTMAA 872

  Fly   628 -------------------------SVRGKLNFISVG-----SKFKTQLG-------ELMEKL-- 653
                                     :...|:|.:|.|     .|.:|..|       ||.:.|
Mosquito   873 EDALGMLVDKPTKKKRWGAALVAEKNKAKKMNTLSKGMYSQVHKMRTIAGVFRATSLELFKTLSI 937

  Fly   654 --EQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSV 716
              ...||:|:|||:.:.:...:.|...:...||:....:......:.|:..|:.|.:....|:.:
Mosquito   938 GPNSGGTHFVRCIRSDLEYRPKGFAPEMVRQQLRAMAVLDTARGRQKGFSHRIPFQEFLRRYQFL 1002

  Fly   717 L--PPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKV 779
            .  ..|.|.: .|..|..:.  |.|..:.:..|.||||.:........|:..:..:.::.|.|.:
Mosquito  1003 AFDFDENVEM-TRDNCRLLL--LRLKLEGWVIGKTKVFLKYYNVEYLQRLYETQVKKIVKIQAMM 1064

  Fly   780 KKWLIRSRWVKSALGALCVIKLRNRIIY----RNKCVLIAQRIARGFLARKQHRPRYQGIGKINK 840
            :.:|.: |.|.:.|..:....:|.|.:.    :::..|..|...||.:|||::||.
Mosquito  1065 RAFLAK-RTVATKLKQVHRESIRKRQMVNQDSQDEAALKIQSAYRGHMARKKYRPL--------- 1119

  Fly   841 IRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKL 905
                                     :||...::|....:. |.|.:.:....|||.|::
Mosquito  1120 -------------------------INDRTGKLDAETAEF-MKPFVYRWRKKSMYQVLL------ 1152

  Fly   906 TVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQR 970
                            |.|..:.|:.:...          |:..|.|:||.|...|........:
Mosquito  1153 ----------------QYRAARYQDLVNLS----------QQVHIYNQRLVAGFATSSNCIMLDK 1191

  Fly   971 LRQEEED-------RRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPP 1028
            :...:.:       |.|...|:.:.:.....|..|  ..:.....:   :...|:|:.:..|:|
Mosquito  1192 IDPNQRNPALLGPQRPAVWKLRFRFDDIPFFDTTY--MCDPSSASY---VYTGNDSDTEDWDAP- 1250

  Fly  1029 VIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAIN 1093
                                           |.:.:|:.::.....::.|            .::
Mosquito  1251 -------------------------------LRRRKNLSSEITKSAQKDY------------RMD 1272

  Fly  1094 TSCDIELLEACRQEFHR-------RLKVYHAWK--AKNRKRTTMDENERAPRSVMEAAFKQPPLV 1149
            ...|:.......:.|||       ||..:|..:  |.||           |||
Mosquito  1273 GPGDVGQHSLANEPFHRDPSLPIKRLSPHHVVEPYAVNR-----------PRS------------ 1314

  Fly  1150 QPIQEIVTAQHRYFRIPFMRANAPD 1174
             |||........|..||:.|.:..|
Mosquito  1315 -PIQSATPMSSVYSPIPYARQSVDD 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	194/742 (26%)
		CBD_MYO6-like	765..913	CDD:409646	26/151 (17%)
		ERM_helical	<954..1020	CDD:466641	10/72 (14%)
		MYO6_MIU_linker	1002..1093	CDD:480843	7/90 (8%)
		MyUb_Myo6	1076..1116	CDD:439319	7/46 (15%)
		Myosin-VI_CBD	1160..1246	CDD:465157	5/15 (33%)
ninaC	XP_318814.5	None