Protein Alignment jar and didum

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_061498899.1
• Gene: didum / 1277086
• VectorBaseID: AGAMI1_009889
• Length: 1868
• Species: Anopheles gambiae
• Alignment Length: 1427
• Identity: 396/1427 - (27%)
• Similarity: 621/1427 - (43%)
• Gaps: 307/1427 - (21%)

  Fly     6 QLVWVRDAAEGYIQGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQ--------DHDDN 62
            :.||     ||.:..:..:...|:.::. |||...    |...:.:..|.|.        ..:|.
Mosquito    19 ETVW-----EGAVVAQDYKQDDKQLKLV-TDRGVE----HTVPLKTPADLPPLRNPTILIGQNDL 73

  Fly    63 CELMLLNEATFLDNLKTRYY-KDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPH 126
            ..|..|:|...|.||:.|:. :..||||...:|:|:|||.|: .||.||.|:.|.|.::|||.||
Mosquito    74 TALSYLHEPDVLYNLEVRFCDRQAIYTYCGIVLVAINPYAEL-PLYGPDLIRAYRGHAMGELEPH 137

  Fly   127 VFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY--SHDSAGPIETKILDANPVL 189
            :||::::|...:...|...|||||||||||||.|.||.::|...  ..:|...||.|:|.::|::
Mosquito   138 IFAVSEEAYAKLEREKCDISIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQIEKKVLASSPIM 202

  Fly   190 EAFGNAKTTRNNNSSRFGKFIEVHY--DAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLL 252
            ||.||||||||:||||||||.::.:  :....:.||.:..|||||||:|.|:..|||||:||.|.
Mosquito   203 EAIGNAKTTRNDNSSRFGKFTKLLFLNNHSMALTGGTMQTYLLEKSRVCFQAPGERNYHIFYQLC 267

  Fly   253 AGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFH 317
            ||..|.  .:|.|...|.:.:|:                 ..:|.|..:        :.|...|.
Mosquito   268 AGREQW--PELMLDHQDKFHFLN-----------------QGQSPNISK--------LSDRDQFE 305

  Fly   318 NLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSG----- 377
            :...||..||..|.|...|..:||:||||||:.|..     |...|.||...::.:|.|.
Mosquito   306 DTLGALKTLGFDDAEIGDIMKVVASVLHLGNVVFNH-----RQKSQTSEVDSEACSIASNDLHLN 365

  Fly   378 ----LLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGL 438
                :|.:|:.|||..||:|.::|....     :::|:....|...||||||.||:.||..||..
Mosquito   366 VACDILQLDRGELRKWLVTRQIESMNDS-----VLIPMNKQTAEATRDALAKHIYAELFQHIVQK 425

  Fly   439 INQSIPFQASN--FYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGL 501
            ||:::......  .:||||||.|||.|.:||||||||||.|||||:.||.::.|.|||.|.|||:
Mosquito   426 INRNLAGSKKQNCCFIGVLDIYGFETFDINSFEQFCINYANEKLQQQFNQHVFKLEQEQYLREGI 490

  Fly   502 NVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLK 566
            ....|.|.|||..|:|||:|. ||..|||||.::|:.|...:..::.:....:.....||..
Mosquito   491 EWKMIDFYDNQPCIDLIESKL-GILDLLDEECRMPRGSDDSWVGKLMEKCGKYPHFDRPRFG--- 551

  Fly   567 AHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF---------- 621
                   ...||::||:..|.|.:..|:|||.|.:...|..:::.....|.|.|.
Mosquito   552 -------TSAFLIKHFSDTVQYESRGFLEKNRDTVSRELVSVLKASGMRLCQRLMVAQEEGGGDG 609

  Fly   622 --------------PSGSSTSVRGKLNFI-------SVGSKFKTQLGELMEKLEQNGTNFIRCIK 665
                          .:..:.||..|...:       :|||:|:..|.:|:..|.....:::||||
Mosquito   610 DAKTAPAAGVKIMVSAARTQSVDKKKKPMTQKQQRKTVGSQFRESLTQLITTLHNTTPHYVRCIK 674

  Fly   666 PNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLP-PELVSLPARTF 729
            ||......::|....:.||:..|.:..:.:...|:|||..:.|.|..|:.:.. .::|....:..
Mosquito   675 PNDDKAPFKWEAPKIVQQLRACGVLETVRISAAGFPSRWKYEDFYERYRLLCKRAQIVDWHVKAT 739

  Fly   730 CEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSD--PENMLAIVAKVKKWLIRSRWVK-- 790
            |..:.::..|....::.|.|::|||.|:....::: |||  .::::.:.:.:::::.|.|:::
Mosquito   740 CTNIVRNWLLDEDKYRLGNTQIFFRAGQVAYLEQV-RSDTRKKHIIVVQSLIRRFVCRRRYLRLK 803

  Fly   791 -SALGAL-----CVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTI 849
             :|||..     .:.:.|...:.:|:..:|.||..||:|.||    ||.      :|||..|...
Mosquito   804 QTALGLQRHARGMLARKRADNLRKNRAAIIIQRYTRGWLQRK----RYV------QIRTAVLGLQ 858

  Fly   850 EIASGLKMGREEIISGVNDI-----------------YR-QIDD---------------AIKKIK 881
            ..|.|. |.|.:..:.:::.                 || ::|.               |.||:|
Mosquito   859 TRARGF-MARRKFRAALDNYKATEVQRFCRGYLARRRYRARLDHIIKCQAAVRRFLARRAFKKLK 922

  Fly   882 MNPRITQREMDSMY--------------------TVVMANMNKLTVDLNTKLKEQQQAEEQERLR 926
            ...| |...:..||                    ...:...|...|::..||...::.|.:.:|.
Mosquito   923 AEAR-TVAHIQKMYKGLENKIIELQQRHDVLSKENAALKKQNVEVVEMRQKLDGMKRLEGELKLL 986

  Fly   927 KIQ------------EALEAERAAK-EAEEQRQREEIENKRLKAEME-----TRRKAAEAQRLRQ 973
            ::|            ..||.||..| :..|::||||.|..|.:...|     .||:..|...:.|
Mosquito   987 QLQLVQKDEKLMLSIRQLEGERDEKMQLLEEKQREEEERARERDAFEQELAKVRREVTEITAVTQ 1051

  Fly   974 EEEDRRAALALQEQL----EKEAKD-------DAKYRQQLEQERR----DHEL---ALRLANESN 1020
            .|:.|..:.|..|::    ::..||       :...||::.:.:|    .|||   :..::|.|:
Mosquito  1052 IEQARLVSQADTEEIHAAYQRTVKDKDVLENENVALRQEVRRLQRIMADSHELKTHSRSVSNASS 1116

  Fly  1021 GQVEDSPPVI-RN--GVNDASP--------------------------MGPNKLISFSQVVSNIA 1056
            ...||..... ||  .:..|||                          :|.|..:|.:.|.|:..
Mosquito  1117 TNEEDYGYTSGRNTLDIRRASPHPYEGDAGGAGGGSAGRGSHRSGGGSVGSNYSVSSTIVASHGE 1181

  Fly  1057 SR-------YLNKSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKV 1114
            ||       :::.....|....|:|..| |.|.....|..:...|:..:           |..|:
Mosquito  1182 SRREEKRHPFVDYERVYRTPPDAIGMLK-DPSDSTVGESPEKDQTAIIL-----------RMRKL 1234

  Fly  1115 YHAWKAKN----------RKRTTMDENERAPRSVMEAAFKQPPLVQPIQEIVTAQHRYFRIPFMR 1169
            :...|:|:          :|.:|....:....|.:|..          .|.:...:...|
Mosquito  1235 FEEEKSKSEQLRKELARLKKSSTFSTEDSIRASELEVE----------NEKLRQDYNLLR----- 1284

  Fly  1170 ANAPDNTKRGLWYAHFDGQWIARQMELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGAE 1231
                ::.|||:.....|.|:.|.|.||...:...:.:......|  ..||...|.| ..|||
Mosquito  1285 ----NSIKRGVESREMDAQYGALQEELKRRREECISLKAVLAQQ--SQSLRSLGQT-ANGAE 1339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	9/41 (22%)
		MYSc_Myo6	71..754	CDD:276833	252/730 (35%)
		CBD_MYO6-like	765..913	CDD:409646	41/210 (20%)
		ERM_helical	<954..1020	CDD:466641	19/88 (22%)
		MYO6_MIU_linker	1002..1093	CDD:480843	27/133 (20%)
		MyUb_Myo6	1076..1116	CDD:439319	7/39 (18%)
		Myosin-VI_CBD	1160..1246	CDD:465157	18/72 (25%)
didum	XP_061498899.1	None