Protein Alignment jar and Myo10A

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_061508751.1
• Gene: Myo10A / 1274922
• VectorBaseID: AGAMI1_013284
• Length: 3076
• Species: Anopheles gambiae
• Alignment Length: 1237
• Identity: 361/1237 - (29%)
• Similarity: 532/1237 - (43%)
• Gaps: 295/1237 - (23%)

  Fly    31 EVTPTD-------------RKYPKRTCHFDDIHSSCD----GPQDH-------------DDNCEL 65
            |::|::             |:.|:.....||:..:..    ||.:.             :|..:|
Mosquito    42 ELSPSEGKESFVRQQPARIRRPPRNKLLPDDVPPNPQTFTLGPNEGNIRARQDLGKTGVEDMTQL 106

  Fly    66 MLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAI 130
            ..|:||:.|.|||.||....|||...:||||:|||:...|.|..:..|.|:||.||.||||:|||
Mosquito   107 EDLHEASLLWNLKLRYDNGLIYTNAGSILIAINPYKMFPESYGIEMAKLYSGRPLGTLPPHLFAI 171

  Fly   131 ADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIET----KILDANPVLEA 191
            ...|   .......|.:::|||||:|||||||.:::||.......|...|    :||:|.|:|||
Mosquito   172 GSAA---HAALPSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASTVITEQILEAAPLLEA 233

  Fly   192 FGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAP 256
            ||||:|.||:|||||||::||::.:.. ::|..|:.||||||||.||:|.||||||||.||.|..
Mosquito   234 FGNARTVRNDNSSRFGKYLEVYFKSGA-IIGAKITQYLLEKSRIVTQAAGERNYHVFYELLGGLA 297

  Fly   257 QQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDK 321
            :..|.|..|.:.|.|.||        |.......||.                    ..:.:|..
Mosquito   298 EPERMKYGLLEADKYFYL--------NQGGSDCAPGR--------------------MDWASLQS 334

  Fly   322 ALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQ-VSEASEQSLTITSGLLGVDQTE 385
            |:..||::::|:.||..::|:||||||:.|..  ..:|.|.: |...|:..:...:.||.:....
Mosquito   335 AMQVLGVTESEREGIVKVLASVLHLGNVYFHR--RQLRHGQEGVEIGSDAEIKWAAHLLQLPSEG 397

  Fly   386 LRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQASNF 450
            :..:|.||:.::     :...:..||.|.:|.:||||||||:||.||:.:|..|| ||..:....
Mosquito   398 ILKSLTSRITET-----RSERLYTPLGIDQALDARDALAKALYSGLFNWLVLRIN-SIVHRGGTH 456

  Fly   451 ---YIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQ 512
               .:.:|||.|||....|||||.||||.||.||.:||.::.|.||..|.||.|....:.:.||.
Mosquito   457 DAQRLSILDIFGFEDLAENSFEQLCINYANESLQLYFNKHVFKLEQAEYARERLEWTNLEWEDNL 521

  Fly   513 DIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEGF 577
            .:|.|:..|..|||.|||:||..|:.:.|.|..:.|.:.|.:.....||..          .:.|
Mosquito   522 PVIHLLAKKPVGIFHLLDDESNFPRANDSSFLEKCHYNHALNELYSRPRVG----------AQEF 576

  Fly   578 LVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLL--------------QTLFPSGSS-T 627
            .:.|:||.|.|..:.|:|||.|||...:..|:.....||:              :|| |.||: .
Mosquito   577 GITHYAGQVWYCVDGFLEKNRDALRMDVIELLSSSTEPLVGEMTKQLRAQRDVGKTL-PKGSNGR 640

  Fly   628 SVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISV 692
            .|..|....:|.::|...|.:|::.:.:....|:||:|||:.....:.:....|.||:..|.:..
Mosquito   641 FVTMKPRTPTVAARFSDSLQQLLQSMAKCNPWFVRCVKPNNDKQALRMDMPCVLQQLRYLGMLDT 705

  Fly   693 LELMEHGYPSRVLFADLYSMYKSVL-PPELVSLPARTFCEAMFQSL---NLSAKDFKFGITKVFF 753
            :::.:.|||.|:.|......|:.:: .|.....|.|..|..:...|   .....||:.|.|:||.
Mosquito   706 IKIRQSGYPVRLRFQHFVERYRHLMRTPLPKGTPYRELCRFVLDELPGTTTEGPDFQLGATRVFL 770

  Fly   754 RPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRI 818
            |..                      :.:.|..||..:..|.|:.:                 ||.
Mosquito   771 REA----------------------LHRTLEASRADRLRLAAVTI-----------------QRT 796

  Fly   819 ARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMN 883
            .||.||||                             |:.||  :.|...|.|
Mosquito   797 VRGMLARK-----------------------------KVQRE--VRGAVTIQR------------ 818

  Fly   884 PRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQRE 948
                       |.....:.|:.....|..:|.|...:..         ::.:|.||...|.::|.
Mosquito   819 -----------YWRGYRDRNRYLTIKNGVVKYQALYKGH---------MQRKRYAKLKNELKRRR 863

  Fly   949 EIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKE---AKDDAKYRQQLEQERRDHE 1010
            |.|  |||       |...||||.:|:.:|.:|:.|....|..   :|.:....||.::.
Mosquito   864 EAE--RLK-------KERTAQRLAKEQVERGSAVPLDIPAELAFIFSKSENWSGQQSDRN----- 914

  Fly  1011 LALRLANESNG--QVEDSPP------------VIRNGVNDASPMGPNKLISFSQVVSNIASRYLN 1061
             .:::.....|  ...|.||            |..|||.    :.|.:.|..:..:|..|:|..:
Mosquito   915 -LVKVVGTVPGPPSAADLPPDLDQFAFGKFSSVYCNGVK----LAPRRDIISAPFLSRAAARDQD 974

  Fly  1062 KSENVR-----------AQQQALGKQK----YDLSKWKYSE-LRDAINTSCDIELLEACRQEFHR 1110
            ..:.:.           |...| .::|    |.:.|...|. |||.|       |::.|.|
Mosquito   975 FKDAIAIFKLIIRWTTDATMDA-NREKILADYIVHKGLSSRGLRDEI-------LVQICNQ---- 1027

  Fly  1111 RLKVYHAWKAKNRKRTTMDENERAPRSVMEAAFKQPPLVQPIQEIVTAQHRYFRIPFMRANAPDN 1175
               ||.|.:|...|..|:       .|...:|| ||.         :|..:|. |.|:..|||.|
Mosquito  1028 ---VYRADEAAAEKLWTL-------MSHCLSAF-QPG---------SAFSKYL-IKFIVDNAPPN 1071

  Fly  1176 TK 1177
            ||
Mosquito  1072 TK 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	5/30 (17%)
		MYSc_Myo6	71..754	CDD:276833	254/709 (36%)
		CBD_MYO6-like	765..913	CDD:409646	22/147 (15%)
		ERM_helical	<954..1020	CDD:466641	16/68 (24%)
		MYO6_MIU_linker	1002..1093	CDD:480843	22/120 (18%)
		MyUb_Myo6	1076..1116	CDD:439319	12/44 (27%)
		Myosin-VI_CBD	1160..1246	CDD:465157	9/18 (50%)
Myo10A	XP_061508751.1	None