Protein Alignment jar and Myo1b

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_038938878.1
• Gene: Myo1b / 117057
• RGDID: 70994
• Length: 1147
• Species: Rattus norvegicus
• Alignment Length: 1208
• Identity: 354/1208 - (29%)
• Similarity: 567/1208 - (46%)
• Gaps: 207/1208 - (17%)

  Fly    61 DNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPP 125
            |...|..|||.||:||||.|:..::||||:.:::|:|||||.: .:|:|:.::.|..|:..||.|
  Rat    19 DTVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSL-PIYSPEKVEDYRNRNFYELSP 82

  Fly   126 HVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPIETKILDANP 187
            |:||::|:|.|.:|.....|.|:::|||||||||::|.::.|   :|........::.::|.:.|
  Rat    83 HIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSTP 147

  Fly   188 VLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLL 252
            ||||||||||.||:|||||||::::.:|.|...:||.||:|||||||:..|...|||:||||.||
  Rat   148 VLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLL 212

  Fly   253 AGAPQQLRDKLSLGKPDD-------------YRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGP 304
            :||.::|..| |:|..::             |.|||     ..:||...
  Rat   213 SGASEELLRK-SMGASEELLHKLKLERDFSRYNYLS-----LDSAKVNG---------------- 255

  Fly   305 LKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASE 369
                 :||..:|..:..|:..:|.||.|...:..:|||||.||||.|:  |:....|...|:..:
  Rat   256 -----VDDAANFRTVRNAMQIVGFSDPEAESVLEVVAAVLKLGNIEFK--PESRMNGLDESKIKD 313

  Fly   370 QS-LTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFD 433
            :: |.....|..:||..|..|...|.:::     |...:...|.:.:|..|||||||.:|||||.
  Rat   314 KNELKEICELTSIDQVVLERAFSFRTVEA-----KQEKVSTTLNVAQAYYARDALAKNLYSRLFS 373

  Fly   434 RIVGLINQSIPFQAS--NFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELY 496
            .:|..||:||..|..  ...:|||||.|||.|..||||||.|||||||||:.|.:..||.|||.|
  Rat   374 WLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEY 438

  Fly   497 KREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWANHYRLGLP 560
            .||.:....|.:.:|..|.:|||..:|||..:||||...| ..:...|..::::..|.|...
  Rat   439 IREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHF--- 500

  Fly   561 RSSRL-KAHRTLRD----EEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTL 620
             .||: |..|.|.|    ...|.::|:||.|.|..|.|::||||.|:..|...:.:..:.|:::|
  Rat   501 -ESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSL 564

  Fly   621 FPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLK 685
            ||.|:...|..| ...:.||:||..:..||:.|:....|:|||||||.|.....|..||...|::
  Rat   565 FPEGNPAKVNLK-RPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFSESLVCHQIR 628

  Fly   686 CSGTISVLELMEHGYPSRVLFADLYSMYKSVLP---PELVSLPARTFCEAMFQSLNLSAKDFKFG 747
            ..|.:..:.:...||..|..:......||.:..   |.... |||:..|.:|..|.:..:::.||
  Rat   629 YLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKG-PARSGVEVLFNELEIPVEEYSFG 692

  Fly   748 ITKVFFR-PGKFVEFDRIMRSDPENMLAIVAKV-KKWLIRSRWVKSALGALCVIKLRNRII---- 806
            .:|:|.| |....:.:.:.:...|::..::.|: :.|..|:.:         ::..|::::
  Rat   693 RSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHF---------LLMKRSQVVIAAW 748

  Fly   807 YR-----------NKCVLIAQRIARGFLARK-----QHRPR-----------YQG---------- 834
            ||           ....|:.|...||:.|||     :|:.|           :.|
  Rat   749 YRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQKRCKEAATTIAAYWHGTQARKERRRL 813

  Fly   835 -----------------IG-----KINKIRTNTLKTIEIA------SGLKMGREEIISGVNDIYR 871
                             :|     ::.:::....:...:|      .|||:.||         ||
  Rat   814 KDEARNKHAIAVIWAFWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRRE---------YR 869

  Fly   872 QI--DDAIKKIKMNPRITQREMDSMYTVVMAN-MNKLT-VDLN-------------TKLKE---- 915
            :.  .:|.|||.   ..|.:.:...|.:.|.| |..|: :|.|             .:||.
  Rat   870 KFFRANAGKKIY---EFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHL 931

  Fly   916 ------QQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQE 974
                  :.|..:|::| ..:|.|||....|: ::......:......|.:|. .|..:.::|:..
  Rat   932 WRCKKYRDQFTDQQKL-IYEEKLEASELFKD-KKALYPSSVGQPFQGAYLEI-NKNPKYKKLKDA 993

  Fly   975 EEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASP 1039
            .|::   :.:.|.:.|..:.:.|...::.....::   |.||::.:||::...|::  .|...|.
  Rat   994 IEEK---IIIAEVVNKINRANGKSTSRIFLLTNNN---LLLADQKSGQIKSEVPLV--DVTKVSM 1050

  Fly  1040 MGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEAC 1104
            ...|.  .|..|.....|...:|.:.:.:....: :....|.:...|:.:..:|.....|.|...
  Rat  1051 SSQND--GFFAVHLKEGSEAASKGDFLFSSDHLI-EMATKLYRTTLSQTKQKLNIEISDEFLVQF 1112

  Fly  1105 RQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAA 1142
            ||:     ||...:...|:|..::...:|....::|.|
  Rat  1113 RQD-----KVCVKFIQGNQKNGSVPTCKRKNNRLLEVA 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	264/710 (37%)
		CBD_MYO6-like	765..913	CDD:409646	38/234 (16%)
		ERM_helical	<954..1020	CDD:466641	11/65 (17%)
		MYO6_MIU_linker	1002..1093	CDD:480843	15/90 (17%)
		MyUb_Myo6	1076..1116	CDD:439319	9/39 (23%)
		Myosin-VI_CBD	1160..1246	CDD:465157
Myo1b	XP_038938878.1	MYSc_Myo1	29..699	CDD:276829	264/710 (37%)
		IQ	760..782	CDD:197470	7/21 (33%)
		Myosin_TH1	952..1129	CDD:461801	36/194 (19%)