DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and myo1f

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_002938604.1	Gene:	myo1f / 100493342	XenbaseID:	XB-GENE-5909751	Length:	1095	Species:	Xenopus tropicalis

Alignment Length:	1072	Identity:	308/1072 - (28%)
Similarity:	496/1072 - (46%)	Gaps:	198/1072 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELP 124
            ||...|..:.|...::|||.||..|.|:||:.::||:|||:::: ..:....|:.|.|.:..|.|
Frog    20 DDMVLLSKITEDAIVENLKKRYLDDYIFTYIGSVLISVNPFKQM-PYFTEREIELYQGAAQYENP 83

  Fly   125 PHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAG-----PIETKILD 184
            ||::|:.|...|:|.:...:|.:|:|||||||||.:.||::.|:  |..|.|     .::..||.
Frog    84 PHIYALTDNMYRNMLIDGENQCVIISGESGAGKTVAAKYIMGYI--SKVSGGGSKVQHVKDIILQ 146

  Fly   185 ANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFY 249
            :||:|||||||||.||||||||||:.|:.:....:..||.||::||||||:.:|:..|||:||||
Frog   147 SNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNENERNFHVFY 211

  Fly   250 MLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ 314
            .|:.||..:.|..|.:..||.:.||:                   :|:.::.:|      .:|.:
Frog   212 QLIEGASDEQRQNLGIMTPDYFFYLN-------------------QSETYKVEG------TNDKK 251

  Fly   315 HFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLL 379
            .|:.:.:|:..:|:|..|:..:..:.|.:||||||:|:|..:..:..|      ...|...:.||
Frog   252 DFYEMLEAMMVIGVSAEEQQMVLQISAGILHLGNISFQEQGNYAKVEC------PDLLDFPAYLL 310

  Fly   380 GVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIP 444
            ||.:..|...|.||.|.||.|| :...|.|.|.:.:||..||||:||:|:|:||.:|..||:::.
Frog   311 GVQKGRLNDKLTSRKMDSKWGG-RSESITVTLNVEQASYTRDALSKALYARVFDFLVESINKAMQ 374

  Fly   445 FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            .....:.||||||.|||.|..|.|||||||:.|||||:.|.:..||.|||.|..||:....|.:.
Frog   375 KPYEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVAEGIRWTPIEYF 439

  Fly   510 DNQDIIELIEAKSN--GIFTLLD-------------EESKLPKPSYSHFTAEVHKSWANHYRLGL 559
            :|:.:.:|||.|.|  ||.::||             :::.|.|...:..|.|...:|
Frog   440 NNKIVCDLIENKLNPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFSNW-------- 496

  Fly   560 PRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSG 624
                          ..||::.|:||.|.|..|.|.|:|.|.|...|..|:|..:...:|:|||..
Frog   497 --------------NLGFVIHHYAGKVSYYVEGFCERNRDVLFIDLIELMQSSEYQFIQSLFPER 547

  Fly   625 SSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGT 689
            ..:..:.:..  :.|||.|.|..:|:..|.:...::|||||||.....:.:|.|....|::..|.
Frog   548 LDSDKKSRPT--TAGSKIKKQANDLVNTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGL 610

  Fly   690 ISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLP-----ARTFCEAMFQSLNLSAKDFKFGIT 749
            ...:.:...|:..|.:|......| ::|..|  :.|     .|...:.:.:|:|:.:..::.|.:
Frog   611 KENIRVRRAGFAYRRVFNKFLQRY-AILTQE--TWPRWRGDERQGVQHLLRSVNMDSDQYQMGKS 672

  Fly   750 KVF------------FRPGKFVEFDRI----------------MRSDPENMLAIVAKVKKWLIRS 786
            |||            .|..||..|.|.                ||.:..|:|....:.::..|..
Frog   673 KVFVKNPESLFLLEEMRERKFDTFARTIQKAWRRYIARRKYEQMREEASNILYGYKERRRNSINR 737

  Fly   787 RWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEI 851
            .:|...||.....:||.                  |:.:::.......:.|.:: |..::|...|
Frog   738 NFVGDYLGMEDRPELRQ------------------FMTKRERIDFADSVSKYDR-RFKSIKRDLI 783

  Fly   852 ASG---LKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKL 913
            .|.   ..:|||::..|...  .||.:.:||                  .:..||..::.|:|:.
Frog   784 LSPKYLYLIGREKVKKGPEK--GQIKEILKK------------------KVEIMNIQSISLSTRQ 828

  Fly   914 KEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAE----METRRK--------AA 966
            .:....:|.:....::...:.|..:...   ::.|||.:::|:..    ::.|.|        ..
Frog   829 DDFFILQEVDHDTLMESVFKTEFISLMC---KRYEEITSRKLRLNFTDTLQLRVKKEGWGGGGTR 890

  Fly   967 EAQRLR-------QEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVE 1024
            ..|.:|       |:...:...:::.:.|.|.:|...|...|....|.....|
Frog   891 NLQFIRGQGEIAVQKAGGKTLVISIGDGLPKNSKPTRKGAPQSRGHRAPPSRA------------ 943

  Fly  1025 DSPP-----VIRNGVNDASPMGPNKLISFSQV 1051
             :||     ..|||. ...|.|.::..|::||
Frog   944 -APPPPSSGSFRNGA-PQFPKGTSRNPSYAQV 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	247/730 (34%)
		MYSc_Myo6	71..754	CDD:276833	243/719 (34%)
		RILP-like	<968..1015	CDD:304877	10/53 (19%)
		Myosin-VI_CBD	1160..1246	CDD:293129
myo1f	XP_002938604.1	MYSc_Myo1	31..677	CDD:276829	243/707 (34%)
		Myosin_TH1	717..915	CDD:368706	38/239 (16%)
		PHA03378	<958..>1041	CDD:223065	5/16 (31%)
		SH3_MyoIe_If_like	1042..1094	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920