Protein Alignment jar and myo1c

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_002942189.2
• Gene: myo1c / 100380193
• XenbaseID: XB-GENE-1009886
• Length: 1044
• Species: Xenopus tropicalis
• Alignment Length: 1107
• Identity: 333/1107 - (30%)
• Similarity: 537/1107 - (48%)
• Gaps: 177/1107 - (15%)

  Fly    13 AAEGYIQG-RITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQDHDDNCELMLL----NEAT 72
            ||...|.| |:|    .|..:|..||.                |.||      .:||    :||.
 Frog     5 AAAPAIDGIRVT----MESALTARDRV----------------GVQD------FVLLENYTSEAA 43

  Fly    73 FLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAIRD 137
            |::||:.|:.::.||||:.::|::||||:|: |:|:...:::|.|.|..|:.||::||||.:.|.
 Frog    44 FIENLRKRFKENLIYTYIGSVLVSVNPYKEL-EIYSKQHMERYRGVSFYEVSPHIYAIADNSYRS 107

  Fly   138 MRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPIETKILDANPVLEAFGNAKTTR 199
            :|..:..|.|::|||||:||||::|.:|:|   .|.:.|....::.::|.:||||||||||||.|
 Frog   108 LRTERKDQCILISGESGSGKTEASKKILQYYAVTCPASDQVETVKDRLLQSNPVLEAFGNAKTLR 172

  Fly   200 NNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDKLS 264
            |:|||||||:::|.:|.|...|||:|.:|||||||:..|:..|||:|:||.||.|..:.|..:|.
 Frog   173 NDNSSRFGKYMDVQFDYKGAPVGGHILNYLLEKSRVVHQNHGERNFHIFYQLLEGGEEDLLRRLG 237

  Fly   265 LGK-PDDYRYL--SGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRL 326
            |.| ..:|:||  ..|.:..:                           |:|...:..:.:||..:
 Frog   238 LDKNAQNYQYLVKGQCARVSS---------------------------INDKNDWKIVRRALSII 275

  Fly   327 GLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTALV 391
            ..::.:...:.|:||:||||||:.|   ..|..|..||:  :|..:...:.||.||...||.:|:
 Frog   276 NFNEDDVEELLSVVASVLHLGNVQF---ASDDHGHAQVT--TENQIKYLARLLAVDAAALRESLI 335

  Fly   392 SRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQASNF------ 450
            .:.:.:||.....     ||.:.:|:.||||||||||.|.|..:|..||:|:.::.|:.
 Frog   336 HKKIIAKGEELNS-----PLNLEQAAYARDALAKAIYGRTFSWLVSKINKSLAYKGSDVLSIGNA 395

  Fly   451 -YIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDI 514
             .||:|||.|||.|..||||||||||||||||:.|.:..||:|||.|:.||:....:.:.:|:.|
 Frog   396 SVIGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYESEGIAWESVQYFNNKII 460

  Fly   515 IELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTL-RDEEGF 577
            .:|:|.|..||.::||||...| :.:...|..::..:..||......:....|..::| |||  |
 Frog   461 CDLVEEKFKGIISILDEECLRPGEATDMTFLEKLEDTVKNHPHFVTHKLGDQKLRKSLGRDE--F 523

  Fly   578 LVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNFISVGSKF 642
            .:.|:||.|.|:...|::||||.|..:|:.::.:..||:....|.....|.   |....:|.::|
 Frog   524 RLLHYAGEVNYSVVGFLDKNNDLLFRNLKEVMCDSGNPIAHQCFDRAELTD---KKRPETVATQF 585

  Fly   643 KTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFA 707
            |..|.:|||.|.....:::||||||......:|:..|...|:|..|.|..:.:...|:..|..:.
 Frog   586 KNSLSKLMEILMSKEPSYVRCIKPNDAKQAARFDEVLIRHQVKYLGLIENVRVRRAGFAYRRKYE 650

  Fly   708 DLYSMYKSVLPPELVSLPART--FCEAMFQSLNLSAKDFKFGITKVFFRPGK--FVEFDRIMRSD 768
            .....|||:.|....:...|.  ....:.:||....:::|.|.||:|.|..|  |...|.:
 Frog   651 IFLQRYKSLCPETWPNWDGRAQDGVAVLVKSLGYKPEEYKMGRTKIFIRFPKTLFATEDAL---- 711

  Fly   769 PENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQ 833
            .|...:|..     .:::|| |..:       .|.:.::.....:..|...||.:.||:...|..
 Frog   712 EERKQSIAT-----FLQARW-KGFV-------QRKKFLHMKHSAIHIQSWWRGNVGRKKAAKRKW 763

  Fly   834 GIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQRE--MDSM-Y 895
            .:..:.:                     .|.|.  :||..          ||..:.|  :|.: |
 Frog   764 AVEVVRR---------------------FIKGF--VYRNY----------PRCPENEYFLDYIRY 795

  Fly   896 TVVM---ANMNKLTVDLNTKLKEQQQAEEQERLRKI----QEALEAERAAKEAEEQRQREEIENK 953
            :.:|   .||.|..:|.:..:......|..|.||::    ...:...|.:.|.::|.:::.:.::
 Frog   796 SFLMNLRRNMPKSVLDKSWPVPPPSLQEASELLREMCMDNMVWMYCRRISPEMKQQLEQKVVASE 860

  Fly   954 RLKAEMETRRKAAE----AQRLRQEEEDRRAALALQEQLEKEAKDDAKY-RQQLEQERRDHELAL 1013
            ..|.:.:...::..    :.||..||.:.:....::.|....|....|| |:..:..||.    |
 Frog   861 IFKDKKDNYPQSVPRLFISTRLGNEEINTKILQNMENQTLTYAVPVVKYDRKGYKPRRRQ----L 921

  Fly  1014 RLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKY 1078
            .|...:...||::.  ::..::.|:..|    ||.|.:..|:...::...:|         |||.
 Frog   922 LLTQNAAYIVEEAK--LKQRIDYANLTG----ISVSSLSDNLFVLHVKCEDN---------KQKG 971

  Fly  1079 DL 1080
            |:
 Frog   972 DV 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/36 (28%)
		MYSc_Myo6	71..754	CDD:276833	253/699 (36%)
		CBD_MYO6-like	765..913	CDD:409646	26/153 (17%)
		ERM_helical	<954..1020	CDD:466641	14/70 (20%)
		MYO6_MIU_linker	1002..1093	CDD:480843	17/79 (22%)
		MyUb_Myo6	1076..1116	CDD:439319	3/5 (60%)
		Myosin-VI_CBD	1160..1246	CDD:465157
myo1c	XP_002942189.2	MYSc_Myo1	43..699	CDD:276829	252/698 (36%)
		IQCG-IQCD	731..762	CDD:483958	6/30 (20%)
		Myosin_TH1	855..1036	CDD:461801	27/138 (20%)