DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and myo1e.1

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001121497.2	Gene:	myo1e.1 / 100158599	XenbaseID:	XB-GENE-1005591	Length:	1108	Species:	Xenopus tropicalis

Alignment Length:	966	Identity:	303/966 - (31%)
Similarity:	467/966 - (48%)	Gaps:	170/966 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELP 124
            ||...|..:.|.:.:||||.||..|.|:||:..:||:|||:::: ..:....|:.|.|.:..|.|
Frog    22 DDMVLLSKITEDSIVDNLKKRYMDDFIFTYIGPVLISVNPFKQM-PYFGDKEIEMYQGAAQYENP 85

  Fly   125 PHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGP----IETKILDA 185
            ||::|:||...|:|.:.:.:|.:|:|||||||||.:.||::.|:. .....||    ::..||.:
Frog    86 PHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYIS-KVSGGGPKVQHVKDIILQS 149

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ||:|||||||||.||||||||||:.|:.:....:..||.||::||||||:..::..||::|:||.
Frog   150 NPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQ 214

  Fly   251 LLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQH 315
            |:.||.:..|:.|.:...|.|.||:                         |.|..|...|:|.:.
Frog   215 LIEGASKDQRESLGITSLDYYNYLN-------------------------QSGSYKVDDINDKRD 254

  Fly   316 FHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLG 380
            |.....|:..:|:|...:..:..:||.|||||||.|:|     :|.....| :|:.|...:.|||
Frog   255 FQETMHAMNVIGISAEGQAMVMQIVAGVLHLGNIGFKE-----KGNYAAVE-NEEFLAFPAFLLG 313

  Fly   381 VDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPF 445
            ::|:.|:..|.||.|.||.|| |...|.|.|.:.:|...||||:||::||:||.:|..||:::..
Frog   314 INQSRLKDKLTSRQMDSKWGG-KSESINVTLNVEQACYTRDALSKALHSRVFDYLVDSINKAMKK 377

  Fly   446 QASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTD 510
            ....:.||||||.|||.|..|.|||||||:.|||||:.|.:..||.|||.|.:||:....|.:.:
Frog   378 DHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFN 442

  Fly   511 NQDIIELIEAKSN--GIFTLLD-------------EESKLPKPSYSHFTAEVHKSWANHYRLGLP 560
            |:.:.:|||.|.|  |:.::||             :::.|.|...:..|.|...||
Frog   443 NKIVCDLIENKVNPPGVMSILDDVCATMHAVGEGADQTLLQKLQMAVGTHEHFNSW--------- 498

  Fly   561 RSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGS 625
                         .:||::.|:||.|.|:.:.|.|:|.|.|...|..|:|....|.:|.|||...
Frog   499 -------------NQGFIIHHYAGKVSYDVDGFCERNRDVLFMDLIELMQSSQQPFMQALFPENL 550

  Fly   626 STSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTI 690
            ....:|:..  :.|||.|.|..:|:..|.:...::|||||||.....|.:|.|....|::..|..
Frog   551 QAEKKGRPT--TAGSKIKKQANDLVNTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLK 613

  Fly   691 SVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEA-----MFQSLNLSAKDFKFGITK 750
            ..:.:...||..|.:|......| ::|..|  :.|:....|.     :..|:|:.:..|:.|.||
Frog   614 ENIRVRRAGYAYRRVFKKFLQRY-AILTKE--TWPSWKGDEKKGVLHLLHSVNMDSDQFQLGKTK 675

  Fly   751 VFFRPGKFV---------EFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRI- 805
            :|.:..:.:         ::|...||       |....:|::.|.::|          ::|.:.
Frog   676 IFIKAPESLFLLEEMRERKYDGYARS-------IQKAWRKYVARKKYV----------QMREQAS 723

  Fly   806 -IYRNKCVLIAQRIARGFLA---RKQHRPRY-QGIGKINKI--RTNTLKTIEIASGLK------- 856
             ::.||.......|.|.|:.   ....||.. |.:||..||  .....|....:.|:|
Frog   724 DLFLNKKERRRNSINRNFIGDYIGMDERPELRQFVGKREKIDFADTVTKYDRRSKGVKRDLILTP 788

  Fly   857 -----MGREEIISG-----VNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNT 911
                 :||:::..|     |.::.:      |||.:. ||                  |:|.|:|
Frog   789 KSVYLIGRDKMKQGPEKGLVKEVLK------KKIDVE-RI------------------LSVSLST 828

  Fly   912 KLKEQQQAEEQERLRKIQEALEAE---RAAKEAEEQRQRE------EIENKRLKAE 958
            ...:.....|||....::...:.|   ..:|..||:.||:      .|.:.:||.|
Frog   829 MQDDFFILHEQEYDSLLESLFKTEFISLLSKHYEEKTQRKLPLKFNNILDMKLKKE 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	254/717 (35%)
		MYSc_Myo6	71..754	CDD:276833	250/706 (35%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
myo1e.1	NP_001121497.2	MYSc_Myo1	33..679	CDD:276829	250/706 (35%)
		Myosin_TH1	719..921	CDD:368706	42/191 (22%)
		SH3_MyoIe_If_like	1055..1107	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920