Protein Alignment beta-PheRS and FRS1

DIOPT Version :9

• Sequence 1: NP_651237.1
• Gene: beta-PheRS / 42888
• FlyBaseID: FBgn0039175
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_013161.1
• Gene: FRS1 / 850749
• SGDID: S000004050
• Length: 595
• Species: Saccharomyces cerevisiae
• Alignment Length: 612
• Identity: 279/612 - (45%)
• Similarity: 391/612 - (63%)
• Gaps: 40/612 - (6%)

  Fly     1 MPTIGVKRDLLFEALGKTYTDDEFQDLCFAFGLELDEVTTEKQMLTKEQGDVAAAANASEEIIYR 65
            |||:.|.:..||:.|||.||..||.:|||.||:|:||.|||:.:.|.|:.::            :
Yeast     1 MPTVSVNKQQLFDLLGKNYTSQEFDELCFEFGMEMDEDTTEEALKTGEEPEL------------K 53

  Fly    66 IDIPANRYDLLCLEGLVTGLLVFQGKLKPPKFQFVELAKRQVLKIDPSTAQIRPYAVAAVLRNVT 130
            :||.||||||||:||:...|..:..:.:.|.::..:...:  |.||.||.||||:|.||||||:.
Yeast    54 LDISANRYDLLCIEGISQSLNEYLERKERPDYKLSKPTTK--LIIDKSTEQIRPFATAAVLRNIK 116

  Fly   131 FTQASYNSFIDLQDKLHQNICRKRTLVAIGTHDLDTLQGPFSYEALAPDQIKFKPLNQTKEMTGS 195
            ..:.||.|||.||||||.|:||.|:|||:||||||:::|||.|.||.|..|||.|||||:|.||.
Yeast   117 LNEKSYASFIALQDKLHANLCRNRSLVAMGTHDLDSIEGPFHYRALPPKDIKFVPLNQTQEFTGD 181

  Fly   196 ELMDFYSTHAQ---LKQYLPIIRESPVYPVIYDANRVVLSLPPIINGDHSKITLKTKNVFIECTA 257
            :|::||.:..|   :.:|:.||.:|||:|||.|:...|.||||:||.:||||::.|:|:.|:.||
Yeast   182 KLIEFYKSPEQKNNIGRYVHIIEDSPVFPVIMDSKDRVCSLPPLINSEHSKISVNTRNILIDITA 246

  Fly   258 TDRTKAKVVLDTIVCLFSEHCAQKFTVEPCDVV-QPDGSVISYPELEVREERISVKRANAYIGID 321
            ||:|||::||:.:..:||.:|.:.|||||.::| :.:|.....|....|...:|:|..|:.:|:|
Yeast   247 TDKTKAEIVLNILTTMFSRYCDEPFTVEPVEIVSEHNGQSRLAPNFNDRIMDVSIKYINSCLGLD 311

  Fly   322 EPAEKLADMLTRMYLEA---KVDGDSLVVKIPPTRHDVIHACDIYEDVAIAYGYNNIKK--SLPA 381
            :.|:::|..|.:|.|.|   |.|.|.|.|.||.||.|::|||||.||.|:.||:||:.|  .|..
Yeast   312 QSADEIAHCLKKMSLHAVQSKEDKDILHVDIPVTRPDILHACDIMEDAAVGYGFNNLPKGEKLSN 376

  Fly   382 FMQIAKQFPLNKLTEQLREQVAQAGFTEALTFTLCSRDDIGRKLNKNIDALPAVHIGNPKTLEFQ 446
            ...|||..|:||:::..|...:||.:.|.|..||||.|:..:.|.::.:...||.:.||||||:|
Yeast   377 ANFIAKPLPINKVSDIFRVASSQATWVEVLPLTLCSHDENFKFLRQSDNGDLAVKLANPKTLEYQ 441

  Fly   447 VVRTTLLPGLLKTLVANRKMPLPLKLFEISDVVVADESTEVGARNERRVCAVNCNKTAGFEVVHG 511
            |||||||||:|||:..|||..||:|:||..|||..|:..|..|.|||...|:...|.:|||::.|
Yeast   442 VVRTTLLPGILKTVKENRKHSLPIKVFETGDVVFKDDKLERKAYNERHWAAIYVGKNSGFEIIQG 506

  Fly   512 LLDRVMQLLSVPW-----KSASGTKGYYLQATEDPS---YFPGRCANVMY---DGV---VIGKIG 562
            ||.::||.....|     .:||| :||:::  ||.|   |||||.|.||:   :|.   .||.:|
Yeast   507 LLGKIMQTFRTEWIADYGAAASG-RGYWIE--EDDSVKTYFPGRGAKVMFRSKEGAEPKQIGHLG 568

  Fly   563 VLHPTVLQAFELTTPCSAVEFTIEPFV 589
            ||||.|:..|::....|.||...|.|:
Yeast   569 VLHPEVMMNFDVPFAASFVEVNAEVFL 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-PheRS	NP_651237.1	PLN02265	1..589	CDD:215149	278/610 (46%)
		B3_4	118..279	CDD:214876	90/163 (55%)
		B5	310..372	CDD:281482	30/64 (47%)
		PheRS_beta_core	390..588	CDD:238392	93/211 (44%)
FRS1	NP_013161.1	pheT_arch	1..595	CDD:273096	278/610 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346070
Domainoid	1	1.000	195	1.000	Domainoid score	I603
eggNOG	1	0.900	-	-		E1_COG0072
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4160
Inparanoid	1	1.050	501	1.000	Inparanoid score	I208
Isobase	1	0.950	-	0	Normalized mean entropy	S494
OMA	1	1.010	-	-		QHG62210
OrthoFinder	1	1.000	-	-		FOG0004315
OrthoInspector	1	1.000	-	-		oto99072
orthoMCL	1	0.900	-	-		OOG6_101233
Panther	1	1.100	-	-	LDO	PTHR10947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1438
SonicParanoid	1	1.000	-	-		X3585
TreeFam	1	0.960	-	-
	16	15.740