DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment beta-PheRS and Lrrc47

DIOPT Version :9

Sequence 1:	NP_651237.1	Gene:	beta-PheRS / 42888	FlyBaseID:	FBgn0039175	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001129138.1	Gene:	Lrrc47 / 362672	RGDID:	1308599	Length:	580	Species:	Rattus norvegicus

Alignment Length:	296	Identity:	79/296 - (26%)
Similarity:	127/296 - (42%)	Gaps:	52/296 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 LKIDPSTAQIRPYAVAAVLRNVTFTQA-SYNSFIDLQDKLHQNICRKRTLVAIGTHDLDTLQGPF 171
            :::.|....:|||.|.||:|.:..... :...|::.|.|||.::|.|||...|.||||..::||.
  Rat   321 VRVSPEVRDVRPYIVGAVVRGMDLQPGNALRRFLNSQTKLHDDLCEKRTAATIATHDLQAVRGPL 385

  Fly   172 SYEALAPDQIKFKPLNQTKEMTGSELMDFYSTHAQ-------------LKQYLPIIRESPVYPVI 223
            .|.|..|:.:|..||.: ||....||:......|:             |.:||.::.....||.:
  Rat   386 LYAARPPEDLKIVPLGR-KEAKAKELVRQLQLEAEEQRKQKKRQSVSGLHRYLHLLDGKENYPCL 449

  Fly   224 YDANRVVLSLPPIINGDHSKITLKTKNVFIECT-ATDRTKAKVVLDTIVCLFSEHCAQKFTVEPC 287
            .||...|:|.|||.|.:.:||...|.:||:|.| ||.....|.::|::|...:|  ..|.|.|
  Rat   450 VDAEGDVISFPPITNSEKTKIKRTTCSVFLEVTSATSLQLCKDIMDSLVLKMAE--LNKSTSE-- 510

  Fly   288 DVVQPDGSVISYPELEVREERISVKRANAYIGIDEPAEKLADMLTRMYLEAKVDGD-SLVVKIPP 351
                           ...|:.:|....:|..|:.:|         .:...|..||. .|||
  Rat   511 ---------------NKEEDMLSGTETDASHGLSDP---------NLNPRAGKDGQCPLVV---- 547

  Fly   352 TRHDVIHACDIYEDVAIAYGYNNIKKSLPAFMQIAK 387
               :.:...|:...:.:.|.......:||.::.:.:
  Rat   548 ---EQVRVVDLEGSLKVVYPSKADLVTLPPYVTVVR 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-PheRS	NP_651237.1	PLN02265	1..589	CDD:215149	79/296 (27%)
		B3_4	118..279	CDD:214876	60/175 (34%)
		B5	310..372	CDD:281482	12/62 (19%)
		PheRS_beta_core	390..588	CDD:238392
Lrrc47	NP_001129138.1	LRR_RI	33..259	CDD:238064
		leucine-rich repeat	53..77	CDD:275380
		LRR_8	76..142	CDD:290566
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..131	CDD:275380
		LRR_8	130..215	CDD:290566
		leucine-rich repeat	132..155	CDD:275380
		leucine-rich repeat	156..181	CDD:275380
		leucine-rich repeat	182..204	CDD:275380
		leucine-rich repeat	205..227	CDD:275380
		B3_4	331..504	CDD:214876	60/175 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D431403at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820