DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta-PheRS and Farsb

DIOPT Version :9

Sequence 1:	NP_651237.1	Gene:	beta-PheRS / 42888	FlyBaseID:	FBgn0039175	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001004252.1	Gene:	Farsb / 301544	RGDID:	1303210	Length:	589	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	370/593 - (62%)
Similarity:	452/593 - (76%)	Gaps:	8/593 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPTIGVKRDLLFEALGKTYTDDEFQDLCFAFGLELDEVTTEKQMLTKEQGDVAAAANASEEIIYR 65
            |||:.|||||||:.||:||||:||.:|||.|||||||:|:|||:::||||:| .|..||:.::|:
  Rat     1 MPTVSVKRDLLFQVLGRTYTDEEFDELCFEFGLELDEITSEKQIISKEQGNV-KAQGASDVVLYK 64

  Fly    66 IDIPANRYDLLCLEGLVTGLLVFQGKLKPPKFQFVELAKRQVLK--IDPSTAQIRPYAVAAVLRN 128
            ||:|||||||||||||..||.||:.::|.|.::.| :.|.::.|  |...||::||:||||||||
  Rat    65 IDVPANRYDLLCLEGLARGLQVFKERIKAPVYKRV-MPKGEIQKLIITEETAKVRPFAVAAVLRN 128

  Fly   129 VTFTQASYNSFIDLQDKLHQNICRKRTLVAIGTHDLDTLQGPFSYEALAPDQIKFKPLNQTKEMT 193
            :.||:..|:|||:||:||||||||||.||||||||||||.|||:|.|..|..|||||||:|||.|
  Rat   129 IKFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYT 193

  Fly   194 GSELMDFYSTHAQLKQYLPIIRESPVYPVIYDANRVVLSLPPIINGDHSKITLKTKNVFIECTAT 258
            ..|||:.|.|...||.||.||...|:||||||:|.||||:||||||:|||||:.|:|:|||||.|
  Rat   194 ACELMNIYKTDNHLKHYLHIIESKPLYPVIYDSNGVVLSMPPIINGNHSKITVNTRNIFIECTGT 258

  Fly   259 DRTKAKVVLDTIVCLFSEHCAQKFTVEPCDVVQPDGSVISYPELEVREERISVKRANAYIGIDEP 323
            |.||||:|||.||.:|||:|..:||||..:||.|.|...:.|||..|:|.:.....|..:||.|.
  Rat   259 DLTKAKIVLDIIVTMFSEYCENQFTVEAAEVVSPSGKSSTLPELPYRKEMVRADLINKKVGIKET 323

  Fly   324 AEKLADMLTRMYLEAKV--DGDSLVVKIPPTRHDVIHACDIYEDVAIAYGYNNIKKSLPAFMQIA 386
            ...||.:||||.|:::|  ||:.:.|:|||||.||||||||.||.|||||||||:.:||....||
  Rat   324 PANLAKLLTRMCLKSEVIGDGNQIEVEIPPTRADVIHACDIVEDAAIAYGYNNIQMTLPKTYTIA 388

  Fly   387 KQFPLNKLTEQLREQVAQAGFTEALTFTLCSRDDIGRKLNKNIDALPAVHIGNPKTLEFQVVRTT 451
            .|||||||||.||..:|.|||||||||.|||::||..||..||.|..|||||||||.||||.|||
  Rat   389 NQFPLNKLTELLRLDMAAAGFTEALTFALCSQEDIADKLGLNISATKAVHIGNPKTAEFQVARTT 453

  Fly   452 LLPGLLKTLVANRKMPLPLKLFEISDVVVADESTEVGARNERRVCAVNCNKTAGFEVVHGLLDRV 516
            ||||||||:.||||||||||||||||:||.|.|.:|||:|.|.:|||..||..|||::||||||:
  Rat   454 LLPGLLKTIAANRKMPLPLKLFEISDIVVQDPSKDVGAKNYRHLCAVYYNKNPGFEIIHGLLDRI 518

  Fly   517 MQLLSVPWKSASGTKGYYLQATEDPSYFPGRCANVMYDGVVIGKIGVLHPTVLQAFELTTPCSAV 581
            ||||.||....||  ||.::|:...::||||||.:...|..|||:|||||.|:..||||.|||::
  Rat   519 MQLLDVPPGEESG--GYVIKASAGSAFFPGRCAEIFVGGQSIGKLGVLHPDVITKFELTMPCSSL 581

  Fly   582 EFTIEPFV 589
            |..||||:
  Rat   582 EINIEPFL 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-PheRS	NP_651237.1	PLN02265	1..589	CDD:215149	369/591 (62%)
		B3_4	118..279	CDD:214876	112/160 (70%)
		B5	310..372	CDD:281482	34/63 (54%)
		PheRS_beta_core	390..588	CDD:238392	129/197 (65%)
Farsb	NP_001004252.1	PLN02265	1..589	CDD:215149	369/591 (62%)
		B3_4	118..279	CDD:214876	112/160 (70%)
		B5	310..374	CDD:281482	34/63 (54%)
		PheRS_beta_core	392..588	CDD:238392	129/197 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352775
Domainoid	1	1.000	264	1.000	Domainoid score	I1856
eggNOG	1	0.900	-	-		E1_COG0072
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4160
Inparanoid	1	1.050	733	1.000	Inparanoid score	I583
OMA	1	1.010	-	-		QHG62210
OrthoDB	1	1.010	-	-		D378921at2759
OrthoFinder	1	1.000	-	-		FOG0004315
OrthoInspector	1	1.000	-	-		oto95754
orthoMCL	1	0.900	-	-		OOG6_101233
Panther	1	1.100	-	-	LDO	PTHR10947
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3585
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770