Protein Alignment beta-PheRS and FARSB

DIOPT Version :9

• Sequence 1: NP_651237.1
• Gene: beta-PheRS / 42888
• FlyBaseID: FBgn0039175
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_005678.3
• Gene: FARSB / 10056
• HGNCID: 17800
• Length: 589
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 369/592 - (62%)
• Similarity: 457/592 - (77%)
• Gaps: 6/592 - (1%)

  Fly     1 MPTIGVKRDLLFEALGKTYTDDEFQDLCFAFGLELDEVTTEKQMLTKEQGDVAAAANASEEIIYR 65
            |||:.|||||||:|||:||||:||.:|||.|||||||:|:||::::||||:| .||.||:.::|:
Human     1 MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQGNV-KAAGASDVVLYK 64

  Fly    66 IDIPANRYDLLCLEGLVTGLLVFQGKLKPPKFQFV-ELAKRQVLKIDPSTAQIRPYAVAAVLRNV 129
            ||:||||||||||||||.||.||:.::|.|.::.| ...|.|.|.|...||:|||:||||||||:
Human    65 IDVPANRYDLLCLEGLVRGLQVFKERIKAPVYKRVMPDGKIQKLIITEETAKIRPFAVAAVLRNI 129

  Fly   130 TFTQASYNSFIDLQDKLHQNICRKRTLVAIGTHDLDTLQGPFSYEALAPDQIKFKPLNQTKEMTG 194
            .||:..|:|||:||:||||||||||.||||||||||||.|||:|.|..|..|||||||:|||.|.
Human   130 KFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYTA 194

  Fly   195 SELMDFYSTHAQLKQYLPIIRESPVYPVIYDANRVVLSLPPIINGDHSKITLKTKNVFIECTATD 259
            .|||:.|.|...||.||.||...|:||||||:|.||||:|||||||||:||:.|:|:|||||.||
Human   195 CELMNIYKTDNHLKHYLHIIENKPLYPVIYDSNGVVLSMPPIINGDHSRITVNTRNIFIECTGTD 259

  Fly   260 RTKAKVVLDTIVCLFSEHCAQKFTVEPCDVVQPDGSVISYPELEVREERISVKRANAYIGIDEPA 324
            .||||:|||.||.:|||:|..:||||..:||.|:|...::|||..|:|.:.....|..:||.|..
Human   260 FTKAKIVLDIIVTMFSEYCENQFTVEAAEVVFPNGKSHTFPELAYRKEMVRADLINKKVGIRETP 324

  Fly   325 EKLADMLTRMYLEAKV--DGDSLVVKIPPTRHDVIHACDIYEDVAIAYGYNNIKKSLPAFMQIAK 387
            |.||.:||||||:::|  ||:.:.::|||||.|:||||||.||.|||||||||:.:||....||.
Human   325 ENLAKLLTRMYLKSEVIGDGNQIEIEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKTYTIAN 389

  Fly   388 QFPLNKLTEQLREQVAQAGFTEALTFTLCSRDDIGRKLNKNIDALPAVHIGNPKTLEFQVVRTTL 452
            |||||||||.||..:|.|||||||||.|||::||..||..:|.|..||||.||||.||||.||||
Human   390 QFPLNKLTELLRHDMAAAGFTEALTFALCSQEDIADKLGVDISATKAVHISNPKTAEFQVARTTL 454

  Fly   453 LPGLLKTLVANRKMPLPLKLFEISDVVVADESTEVGARNERRVCAVNCNKTAGFEVVHGLLDRVM 517
            |||||||:.||||||||||||||||:|:.|.:|:|||:|.|.:|||..||..|||::||||||:|
Human   455 LPGLLKTIAANRKMPLPLKLFEISDIVIKDSNTDVGAKNYRHLCAVYYNKNPGFEIIHGLLDRIM 519

  Fly   518 QLLSVPWKSASGTKGYYLQATEDPSYFPGRCANVMYDGVVIGKIGVLHPTVLQAFELTTPCSAVE 582
            |||.||.....|  ||.::|:|.|::||||||.:...|..:||:|||||.|:..||||.|||::|
Human   520 QLLDVPPGEDKG--GYVIKASEGPAFFPGRCAEIFARGQSVGKLGVLHPDVITKFELTMPCSSLE 582

  Fly   583 FTIEPFV 589
            ..:.||:
Human   583 INVGPFL 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-PheRS	NP_651237.1	PLN02265	1..589	CDD:215149	368/590 (62%)
		B3_4	118..279	CDD:214876	112/160 (70%)
		B5	310..372	CDD:281482	34/63 (54%)
		PheRS_beta_core	390..588	CDD:238392	124/197 (63%)
FARSB	NP_005678.3	PLN02265	1..589	CDD:215149	368/590 (62%)
		B3_4	118..279	CDD:214876	112/160 (70%)
		B5	310..374	CDD:281482	34/63 (54%)
		PheRS_beta_core	392..588	CDD:238392	124/197 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158770
Domainoid	1	1.000	265	1.000	Domainoid score	I1918
eggNOG	1	0.900	-	-		E1_COG0072
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4160
Inparanoid	1	1.050	740	1.000	Inparanoid score	I593
Isobase	1	0.950	-	0	Normalized mean entropy	S494
OMA	1	1.010	-	-		QHG62210
OrthoDB	1	1.010	-	-		D378921at2759
OrthoFinder	1	1.000	-	-		FOG0004315
OrthoInspector	1	1.000	-	-		oto88624
orthoMCL	1	0.900	-	-		OOG6_101233
Panther	1	1.100	-	-	LDO	PTHR10947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1438
SonicParanoid	1	1.000	-	-		X3585
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750