DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spps and CRZ1

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_014371.1	Gene:	CRZ1 / 855704	SGDID:	S000004972	Length:	678	Species:	Saccharomyces cerevisiae

Alignment Length:	702	Identity:	149/702 - (21%)
Similarity:	239/702 - (34%)	Gaps:	242/702 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 ATSSGG----LQNLMQAQSLQMPSASQMQIIPQ----------FSQIAQIVTPNGQIQQVQL--- 362
            :::||.    |.:|.....::|.||:..:.|.:          .|.:..:::|:.......|
Yeast    42 SSNSGSHTFQLSDLDLDVDMRMDSANSSEKISKNLSSGIPDSFDSNVNSLLSPSSGSYSADLNYQ 106

  Fly   363 AMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQA 427
            ::..|.||                   |||.||||.|||||.||||.||||:|....:.:|
Yeast   107 SLYKPDLP-------------------QQQLQQQQLQQQQQQQQQQQQQQQKQTPTLKVEQ---- 148

  Fly   428 ISDASAGGQLPPNQPITITNAQGQQLTVIPAQ-LRPNAPTAPTPAPAGVP-----------TP-- 478
             ||......:       :|.|..|....:..| |.|.:....|...:|:.           ||
Yeast   149 -SDTFQWDDI-------LTPADNQHRPSLTNQFLSPRSNYDGTTRSSGIDSNYSDTESNYHTPYL 205

  Fly   479 -----MQMPNLQALPIQN--IPGLGQVQIIHANQLPPNLPANFQQV--------LTQLPMSHPQV 528
                 :..|.:..|...|  ...|..|..:::|.|.|.....::.:        |..|..|...:
Yeast   206 YPQDLVSSPAMSHLTANNDDFDDLLSVASMNSNYLLPVNSHGYKHISNLDELDDLLSLTYSDNNL 270

  Fly   529 --------------------QTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPA 573
                                .||.....:.|.:..:..:|:.:|         |.|:|.:|...|
Yeast   271 LSASNNSDFNNSNNGIINTADTQNSTIAINKSKVGTNQKMLLTI---------PTSSTPSPSTHA 326

  Fly   574 S--TPNTASPQQ---------------QQIKFLHTESNSL---SSLSIP---------------- 602
            :  || ..|.|:               .|:|....||.|.   ::|..|
Yeast   327 APVTP-IISIQEFNEGHFPVKNEDDGTLQLKVRDNESYSATNNNNLLRPDDNDYNNEALSDIDRS 390

  Fly   603 -------ASIQITALPQQATNTPNTPATTQPIPVSLPARS-----KVNAVTTSSTQITIAPTGGQ 655
                   ..:::....::::.|.|...|::.   |..:||     |..:::.:..::.      :
Yeast   391 FEDIINGRKLKLKKSRRRSSQTSNNSFTSRR---SSRSRSISPDEKAKSISANREKLL------E 446

  Fly   656 VVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKPRLKRV 720
            :..:...:.......|..|.|.|:..|.:.|:.|.:           .......|.  ||:::..
Yeast   447 MADLLPSSENDNNRERYDNDSKTSYNTINSSNFNED-----------NNNNNLLTS--KPKIESG 498

  Fly   721 ACTCPNCTD----------------------GEKHSD------------KKRQHI---------- 741
            .....|..|                      |.|:.|            ||..::
Yeast   499 IVNIKNELDDTSKDLGILLDIDSLGQFEQKVGFKNDDNHENNDNGTFSVKKNDNLEKLDSVTNNR 563

  Fly   742 -------CHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKR 799
                   |.:  |.|.:.:..:|::|||.||.||||:||  .|||.|.|..:.:||...|||:||
Yeast   564 KNPANFACDV--CGKKFTRPYNLKSHLRTHTNERPFICS--ICGKAFARQHDRKRHEDLHTGKKR 624

  Fly   800 FQC---------QECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKG 842
            :.|         ..|.|||.|||.|.:|.||....|....|.| ..:||..|
Yeast   625 YVCGGKLKDGKPWGCGKKFARSDALGRHFKTESGRRCITPLYE-EARQEKSG 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	46/161 (29%)
		C2H2 Zn finger	742..764	CDD:275368	7/21 (33%)
		zf-H2C2_2	756..783	CDD:290200	16/26 (62%)
		C2H2 Zn finger	772..794	CDD:275368	9/21 (43%)
		zf-H2C2_2	786..809	CDD:290200	10/31 (32%)
		zf-C2H2	800..822	CDD:278523	11/30 (37%)
		C2H2 Zn finger	802..822	CDD:275368	11/28 (39%)
CRZ1	NP_014371.1	COG5048	139..617	CDD:227381	92/525 (18%)
		C2H2 Zn finger	571..591	CDD:275368	7/21 (33%)
		C2H2 Zn finger	599..619	CDD:275368	9/21 (43%)
		C2H2 Zn finger	627..655	CDD:275368	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030