DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spps and sp3

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	XP_002934651.1	Gene:	sp3 / 733736	XenbaseID:	XB-GENE-977158	Length:	750	Species:	Xenopus tropicalis

Alignment Length:	970	Identity:	256/970 - (26%)
Similarity:	358/970 - (36%)	Gaps:	345/970 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GSSKATIPPNGASAAASQT-----QVHGAPG-----TPTM----QQIINIHQMPPQFAGGAVAGN 74
            |.|.:....:.......||     |:.|.|.     ||..    .:..||.|:|   .|..|..:
Frog    29 GDSSSAGDDSDQGGGGGQTEDLAVQISGGPNRWEVLTPAQAALKDEAGNIVQIP---GGATVTSS 90

  Fly    75 GQNAGMPQNMFQIVQPMPMQTVNIDGQEAIF--IPNLNAQLATAQAVNFNGQQAFITPNGQILRA 137
            ||..            :|:||:.   .:.:|  .|..:....|...|.:.......|.:||.:
Frog    91 GQYV------------LPIQTLQ---NQHLFSVAPGSDTANGTLSNVQYQVIPQLQTSDGQQV-- 138

  Fly   138 PQMAANPAASNCIQLQQLNGLGQEQTQLITIPGT---NIQIPVTNLIQQQQQAQQVHQ-GTVQQQ 198
             |:....::.|       .||.|:..|:..|||.   ::.....|::.|..|.|  |. |:||.|
Frog   139 -QLGFTTSSDN-------GGLDQDGGQIQIIPGNHSGSLLSSSPNILTQAGQIQ--HSGGSVQIQ 193

  Fly   199 AQGTNASGANGSGVTNSGT--AGQ----------LPGSIT-IPGTNLQIPTSVAAANGLLGNISN 250
                        |||..||  |||          |||:|| :|..::.:.:.     ||.|:...
Frog   194 ------------GVTIGGTSYAGQTQVVANVPIGLPGNITFVPINSVDLDSL-----GLTGSTEA 241

  Fly   251 I-SNLLGGGQSIK---LENGQLQMRPQLVQFPAP-----------AMPQQQQTVAVQIPV----- 295
            : :.|...|..|.   :||.:...|....:..:|           .:|....:   |:||
Frog   242 MTAGLTADGHLISGHGMENSENSERTAEHEHISPDGVDTNSDTDLFVPTSSSS---QLPVTIDGT 303

  Fly   296 ----QTANGQTIYQTVHVPVQAAATSSGGLQNLM--QAQSLQMPSASQMQIIPQFSQIAQIVTPN 354
                |.||..|...:.|  ||.:......:|..|  ::|::|: ||||.
Frog   304 GMLQQNANSLTDSPSGH--VQTSDLHGNYIQTSMTDESQNIQV-SASQT---------------- 349

  Fly   355 GQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQ-QQAQQQQQQQVQ 418
             .:||                ||:|:.....|.|:.|...||..|..|...| ..:|..|..|:|
Frog   350 -MVQQ----------------IHLQDSQPTSQAQLVQSIAQQAIQAVQGGTQGLSSQALQNLQLQ 397

  Fly   419 AQHQQLLQAISDASAGGQLPPN----------QPITITNAQGQQLTVIPAQLRPNAPTAPTPAPA 473
            ......|......:..||:...          |.:.|.|:..||:|:.|.|      |......|
Frog   398 LNPGTFLIQAQTVTPSGQIAWQTFQVQGVQNLQNLQIPNSSAQQITLTPVQ------TLTLGQVA 456

  Fly   474 GVPTPM-----QMPNLQALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQ 533
            |..||:     |:||||.:.:.::...| :.:.|.:.  .:.|...:...|:...|..|:...|
Frog   457 GGGTPVSLNAGQLPNLQTVTVNSVDAAG-IHLHHGDN--SDSPTEIETHQTRQHFSSLQLSNFG- 517

  Fly   534 VQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSS 598
                            ..||:|.||                      |.:.|
Frog   518 ----------------IRIKEEEPD----------------------PDEWQ------------- 531

  Fly   599 LSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTGGQVVSVTTQA 663
                                            |...|.||  |...|.:.:     |||.
Frog   532 --------------------------------LAGDSTVN--TNDLTHLRV-----QVVD----- 552

  Fly   664 RGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKPRLKRVACTCPNCT 728
                          ..:..|:|                          |.| ||:|||||||||.
Frog   553 --------------DELDQPNQ--------------------------EGK-RLRRVACTCPNCK 576

  Fly   729 DGE---KHSDKKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRH 790
            ||.   .:..||:||||||.||.||||||||||||||||:|||||||:|.|||||||||||||||
Frog   577 DGAGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCTWMFCGKRFTRSDELQRH 641

  Fly   791 RRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKGGNAPKSISTVNGI 855
            ||||||||:|.|.||:|:|||||||:||||||               |..||.:|..::     :
Frog   642 RRTHTGEKKFVCPECSKRFMRSDHLAKHIKTH---------------QNKKGIHASSAV-----L 686

  Fly   856 VTIEIPGGGSAAAGSGASSVAATVAGSTVTPGGATI--------------VQLPTVEASG 901
            .:||.....:.....|.:.:.|.:...:|: |..|:              :.|..|..||
Frog   687 ASIEAKPEDTLITTEGTTLILANIQQGSVS-GIGTVHTGTSNQDLLSNSEIPLQLVAVSG 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	80/104 (77%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:290200	23/26 (88%)
		C2H2 Zn finger	772..794	CDD:275368	19/21 (90%)
		zf-H2C2_2	786..809	CDD:290200	18/22 (82%)
		zf-C2H2	800..822	CDD:278523	16/21 (76%)
		C2H2 Zn finger	802..822	CDD:275368	15/19 (79%)
sp3	XP_002934651.1	C2H2 Zn finger	593..615	CDD:275368	19/21 (90%)
		zf-H2C2_2	607..634	CDD:372612	23/26 (88%)
		C2H2 Zn finger	623..645	CDD:275368	19/21 (90%)
		zf-H2C2_2	637..660	CDD:372612	18/22 (82%)
		zf-C2H2	651..673	CDD:333835	16/21 (76%)
		C2H2 Zn finger	653..673	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10679
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49214
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020