Protein Alignment Spps and SP4

DIOPT Version :10

• Sequence 1: NP_001262902.1
• Gene: Spps / 42882
• FlyBaseID: FBgn0039169
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_003103.2
• Gene: SP4 / 6671
• HGNCID: 11209
• Length: 784
• Species: Homo sapiens
• Alignment Length: 903
• Identity: 261/903 - (28%)
• Similarity: 358/903 - (39%)
• Gaps: 289/903 - (32%)

  Fly     6 SAASAATSAPPAT-------PLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMP 63
            :|.....|.|||:       |.::..||.::   |..||:.::|: .|...||...|:|.: |.|
Human   100 NAWQLVASTPPASKENNVSQPASSSSSSSSS---NNGSASPTKTK-SGNSSTPGQFQVIQV-QNP 159

  Fly    64 PQFAGGAVAGNGQNAGMPQNMFQIVQPMPMQTVNIDGQEAIFIPNLNAQLATAQAVNFNGQQAFI 128
                    :|:.|...:||     :|.:..|.:.|:...:..:.:|..|:   |.::....||.:
Human   160 --------SGSVQYQVIPQ-----LQTVEGQQIQINPTSSSSLQDLQGQI---QLISAGNNQAIL 208

  Fly   129 TPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQT-------------QLITIPGTNIQIPVTNL 180
            |           |||..||..|..|.|    ..||             ||.|:|||..|:..|
Human   209 T-----------AANRTASGNILAQNL----ANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTT-- 256

  Fly   181 IQQQQQAQQVHQGTVQQQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIP--TSVAAANG 243
                                                    ||  |.|.|..|.:|  .:|||..|
Human   257 ----------------------------------------LP--INIGGVTLALPVINNVAAGGG 279

  Fly   244 LLGNISNISNLLGGGQSIKLENGQLQMRPQLVQFPA---------PAMPQQQQTVAVQIPVQTAN 299
             .|.:...:.....|.|    ||.     |||..|.         |..|....|..........:
Human   280 -TGQVGQPAATADSGTS----NGN-----QLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTS 334

  Fly   300 GQTIYQTVHVPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQIAQIVTPNG--------- 355
            ..|:..:......|:.::|...:.:.::|:   |:|::.:     :|.:..:.|||
Human   335 SDTLVSSADTGQYASTSASSSERTIEESQT---PAATESE-----AQSSSQLQPNGMQNAQDQSN 391

  Fly   356 QIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQ 420
            .:||||:..     .|....|.||.|.||..|.:..|..|.|:.|..|..|||..|..|
Human   392 SLQQVQIVG-----QPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQ------ 445

  Fly   421 HQQLLQAISDASAGGQLPPNQPITITNAQGQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQ 485
                |||::                           |.|:...|||.         ||....:.|
Human   446 ----LQAVN---------------------------PTQVLIRAPTL---------TPSGQISWQ 470

  Fly   486 ALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMIT 550
            .:.:|||..|..:|:.:         |...|.||..|:|.....|..|:
Human   471 TVQVQNIQSLSNLQVQN---------AGLSQQLTITPVSSSGGTTLAQI---------------- 510

  Fly   551 SIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQAT 615
                      .|::..|.|    .|.|||  |...:..|.|.  |:::|. .|.:|:..:|...|
Human   511 ----------APVAVAGAP----ITLNTA--QLASVPNLQTV--SVANLG-AAGVQVQGVPVTIT 556

  Fly   616 NTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTGGQVVSVTTQARG-ATASIRSTNTSTTT 679
            :..........:.|.               |.||||       ||....| |.|:|.:.:....|
Human   557 SVAGQQQGQDGVKVQ---------------QATIAP-------VTVAVGGIANATIGAVSPDQLT 599

  Fly   680 ITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKP--RLKRVACTCPNCTDGE----KHSDKKR 738
                 |.||..              |..|:..|.:|  ||:||||:||||.:||    ....||:
Human   600 -----QVHLQQ--------------GQQTSDQEVQPGKRLRRVACSCPNCREGEGRGSNEPGKKK 645

  Fly   739 QHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQ 803
            ||||||.||.||||||||||||||||||||||:|:|.|||||||||||||||||||||||||:|.
Human   646 QHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECP 710

  Fly   804 ECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKGGNAPKSISTVNG---IVTI 858
            ||:|:||||||||||:|||...:.|...:.:     ...|....|::.|.|   |||:
Human   711 ECSKRFMRSDHLSKHVKTHQNKKGGGTALAI-----VTSGELDSSVTEVLGSPRIVTV 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	SP1-4_N	<281..>371	CDD:425404	16/98 (16%)
		Atrophin-1	284..>630	CDD:460830	73/354 (21%)
		SP1-4_N	<713..741	CDD:425404	16/33 (48%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:463886	23/26 (88%)
		C2H2 Zn finger	772..794	CDD:275368	19/21 (90%)
		zf-H2C2_2	786..809	CDD:463886	19/22 (86%)
		zf-C2H2	800..822	CDD:395048	16/21 (76%)
		C2H2 Zn finger	802..822	CDD:275368	15/19 (79%)
SP4	NP_003103.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68
		SP4_N	32..648	CDD:411773	180/781 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..150		13/44 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..390		22/125 (18%)
		9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868	467..475		1/7 (14%)
		zf-C2H2	647..671	CDD:395048	21/23 (91%)
		C2H2 Zn finger	649..671	CDD:275368	19/21 (90%)
		zf-C2H2	677..701	CDD:395048	20/23 (87%)
		C2H2 Zn finger	679..701	CDD:275368	19/21 (90%)
		zf-H2C2_2	693..716	CDD:463886	19/22 (86%)
		zf-C2H2	707..729	CDD:395048	16/21 (76%)
		C2H2 Zn finger	709..729	CDD:275368	15/19 (79%)