DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spps and SP1

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_612482.2	Gene:	SP1 / 6667	HGNCID:	11205	Length:	785	Species:	Homo sapiens

Alignment Length:	862	Identity:	257/862 - (29%)
Similarity:	349/862 - (40%)	Gaps:	183/862 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 NFNGQQAFITPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQTQ-----LITIPGTNIQIPVTN 179
            |.||..||               :.|.|:........|.|.:::|     |:....:.|:.|..|
Human    28 NGNGGGAF---------------SQARSSSTGSSSSTGGGGQESQPSPLALLAATCSRIESPNEN 77

  Fly   180 LIQQQQQAQQVHQGTVQQQAQGTNAS-GANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANG 243
            ....|..:|.  .||.:.....|..| ||||..:.:| ::|..|.|....|         ::.||
Human    78 SNNSQGPSQS--GGTGELDLTATQLSQGANGWQIISS-SSGATPTSKEQSG---------SSTNG 130

  Fly   244 LLGNISNISNLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQQQQTVAVQIPVQTANGQTIYQTVH 308
            ..|:.|:.:..:.|||.:......||.:..|...|. .||..|..|..|.  ||.:||.:
Human   131 SNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPG-VMPNIQYQVIPQF--QTVDGQQL----- 187

  Fly   309 VPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQIAQIVTPNGQIQQVQLAMPYPQLPPNA 373
               |.|||.:          .:|...:.|:||||..:|  ||:|..|....:..|||
Human   188 ---QFAATGA----------QVQQDGSGQIQIIPGANQ--QIITNRGSGGNIIAAMP-------- 229

  Fly   374 NIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQAISDASAGGQLP 438
            |::....|.|.....|...|.|.......................|......||::.:|:|.|..
Human   230 NLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQES 294

  Fly   439 PNQPIT--------------------ITNAQGQQLTVIPAQLRPNAPTAPTPAPAGV----PTPM 479
            .:||:|                    .|||.....|...:.:  ......|...:|.    .||.
Human   295 GSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNM--GIMNFTTSGSSGTNSQGQTPQ 357

  Fly   480 QMPNLQ---ALPI-QNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQ----VQV 536
            ::..||   ||.| ||....|.:|.....:...|.....||:|.|     ||:...||    :|.
Human   358 RVSGLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQ-----PQLVQGGQALQALQA 417

  Fly   537 MPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSSLSI 601
            .|.......||   :|.||........:...:.|....|| |..|..|    :..::..|.:|.:
Human   418 APLSGQTFTTQ---AISQETLQNLQLQAVPNSGPIIIRTP-TVGPNGQ----VSWQTLQLQNLQV 474

  Fly   602 --PASIQITALPQQA-----TNTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTGGQVVSV 659
              |.:..||..|.|.     |::.||..|......|:||    ..||.::.|::..| |.|.:::
Human   475 QNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPA----GTVTVNAAQLSSMP-GLQTINL 534

  Fly   660 TTQARGATA-SIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGG------GTATGEPKP-- 715
            :  |.|.:. .:.........|......|      .|.:|....||.|      |...||..|
Human   535 S--ALGTSGIQVHPIQGLPLAIANAPGDH------GAQLGLHGAGGDGIHDDTAGGEEGENSPDA 591

  Fly   716 ------RLKRVACTCPNCTDGEKHSD----KKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPF 770
                  |.:|.|||||.|.|.|....    ||:||||||.||.||||||||||||||||||||||
Human   592 QPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPF 656

  Fly   771 VCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELS 835
            :|:|::||||||||||||||:|||||||:|.|.||.|:||||||||||||||
Human   657 MCTWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTH------------- 708

  Fly   836 IKQETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSGASSVAAT---VAGSTVTPGGAT------- 890
              |..|||   ..::...|.:.:: .|.||..:|:...|...|   ||...:.|.|..
Human   709 --QNKKGG---PGVALSVGTLPLD-SGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGI 767

  Fly   891 ----IVQLPTVEASGGG 903
                :..|.::..||.|
Human   768 NVMQVADLQSINISGNG 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	78/105 (74%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:290200	22/26 (85%)
		C2H2 Zn finger	772..794	CDD:275368	17/21 (81%)
		zf-H2C2_2	786..809	CDD:290200	17/22 (77%)
		zf-C2H2	800..822	CDD:278523	17/21 (81%)
		C2H2 Zn finger	802..822	CDD:275368	16/19 (84%)
SP1	NP_612482.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		18/81 (22%)
		Repressor domain	2..82		14/68 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..141		9/41 (22%)
		Transactivation domain A (Gln-rich)	146..251		37/135 (27%)
		Transactivation domain B (Gln-rich)	261..495		55/248 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..395		15/67 (22%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	462..470		0/7 (0%)
		Transactivation domain C (highly charged)	496..610		32/126 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..598		7/30 (23%)
		VZV IE62-binding	619..785		93/185 (50%)
		C2H2 Zn finger	628..650	CDD:275368	19/21 (90%)
		zf-H2C2_2	642..669	CDD:290200	22/26 (85%)
		C2H2 Zn finger	658..680	CDD:275368	17/21 (81%)
		zf-H2C2_2	672..695	CDD:290200	17/22 (77%)
		zf-C2H2	686..708	CDD:278523	17/21 (81%)
		C2H2 Zn finger	688..708	CDD:275368	16/19 (84%)
		Domain D	708..785		20/96 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151671
Domainoid	1	1.000	67	1.000	Domainoid score	I9785
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3329
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41988
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	8.030