DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spps and Zfp352

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001102827.1	Gene:	Zfp352 / 502968	RGDID:	1563227	Length:	559	Species:	Rattus norvegicus

Alignment Length:	644	Identity:	137/644 - (21%)
Similarity:	214/644 - (33%)	Gaps:	207/644 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 QLVQFPAPAMPQQQQTVAVQI---PVQTANGQTIYQTVHVPVQAAATSS---------GGLQNLM 325
            |||...:..||..:||.....   |.:||..|.  .|.|   :..||.|         ..:|.::
  Rat    26 QLVSGQSSEMPTWKQTGMASSYFNPYETACTQN--STAH---RGKATDSYFGEPSETASFIQQVV 85

  Fly   326 QAQSLQMPSASQMQIIPQFSQIAQIVTPNGQIQQVQLAMPYP---------------QLPPNANI 375
            .|:..:.|..|      .|.::....|.         .:|.|               .|..:..:
  Rat    86 SAEQNKSPEGS------LFMKLNSTATS---------CLPQPLDTRKTLYNEGYWRRTLNSDKTL 135

  Fly   376 IHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQAISDASAGGQLPPN 440
            : |||....:.|::...............|......             |.::.|.:.||.|  .
  Rat   136 L-IQNTDLCESQRITFGNHPVALSGSHAGQVPNVDH-------------LDSVWDQTFGGDL--E 184

  Fly   441 QPIT-------ITNAQGQQLTVIPAQLRPNAPTAPT----------------PAPAGVPTPMQMP 482
            .|.:       :|...|..||:..:|:     .||:                ..|.|
  Rat   185 MPFSDDSYYSQMTTKYGGHLTLYESQM-----IAPSCNQVLDTDQFVTSFYEQNPFG-------- 236

  Fly   483 NLQALPIQNIPGLGQVQII-HANQ--LPPNLPANFQQVLTQLPMSHPQVQT--QGQVQVMPKQEP 542
            :.|..|:......|...|: :|.|  ..|.:..|..|:.....|:....|.  .||..:...:..
  Rat   237 DQQRSPVTENKFYGDQMIVPNAYQAFYEPQVRDNSDQINFDSRMASFSGQNICSGQESIFQDEHS 301

  Fly   543 QS---------------PTQMITSI-------KQEPPDTFGPISATGNPPAPASTPNTASPQQQQ 585
            .|               ..|:|:.|       .|:|..||.        ..|..:..|.|..:..
  Rat   302 LSGFQTSGYRCDQDWIMNHQVISPIGGQTLYDSQKPTSTFN--------TTPHGSKRTTSSAEDN 358

  Fly   586 IKFLHTESNSLSSLSI-----PASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSST 645
            :.: |.|::|.|..::     .||:.......| ..|.||..:.:|            .||:.|.
  Rat   359 LAW-HPETSSSSEETLYMGQMRASVDQNVYASQ-NGTANTEESLEP------------EVTSLSN 409

  Fly   646 QITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATG------- 703
            |   ||..|:               .|.::|:..|...||       .::|..|...|
  Rat   410 Q---APDVGE---------------SSDSSSSPLIRIQSQ-------GISSASGLDQGQHPQIRL 449

  Fly   704 --GGGGTATGEPKPRLKRVACTCPNCTDGEKHSDKKRQHICHITGCHKVYGKTSHLRAHLRWHTG 766
              ......:.|..|.|||.:||                    ..||.|.|.|:.||:.|:|.|||
  Rat   450 DLKTQSPVSPEKPPTLKRYSCT--------------------YQGCEKSYTKSHHLKDHMRKHTG 494

  Fly   767 ERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKS 825
            |:||||....|..:|.||.:|.||::.|:||:.:.|.:|||.:.|..:|.:|..:|.::
  Rat   495 EKPFVCDQIGCNWKFFRSIDLNRHKKKHSGERPYACPKCNKNYSRPYYLKQHQVSHIQA 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	35/101 (35%)
		C2H2 Zn finger	742..764	CDD:275368	9/21 (43%)
		zf-H2C2_2	756..783	CDD:290200	14/26 (54%)
		C2H2 Zn finger	772..794	CDD:275368	8/21 (38%)
		zf-H2C2_2	786..809	CDD:290200	10/22 (45%)
		zf-C2H2	800..822	CDD:278523	7/21 (33%)
		C2H2 Zn finger	802..822	CDD:275368	7/19 (37%)
Zfp352	NP_001102827.1	zf-C2H2	468..492	CDD:278523	11/43 (26%)
		C2H2 Zn finger	470..492	CDD:275368	11/41 (27%)
		zf-H2C2_2	484..>502	CDD:290200	12/17 (71%)
		C2H2 Zn finger	500..522	CDD:275368	8/21 (38%)
		zf-H2C2_2	514..539	CDD:290200	10/24 (42%)
		C2H2 Zn finger	530..550	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910