DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spps and pad

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_650534.2	Gene:	pad / 41981	FlyBaseID:	FBgn0038418	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	1019	Identity:	232/1019 - (22%)
Similarity:	348/1019 - (34%)	Gaps:	357/1019 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SAATSAPPATPLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMPPQFAGGAVAG 73
            |.|.||||.              ||||..:.:           .:..||....|.||........
  Fly   116 SVAQSAPPV--------------PNGAQQSGN-----------LLNSIIQAVNMQPQQQYTITMD 155

  Fly    74 NGQNAGMPQNMFQIVQPMPMQTVNIDGQEAI--FI---PNLNAQLATAQAVNFNGQQAFITPNGQ 133
            ||......|:     |.||...:..:.|.|:  ||   |::.                 |||.|:
  Fly   156 NGVQQQQQQH-----QAMPEVQIKSERQTALEEFIRLKPDIK-----------------ITPLGK 198

  Fly   134 ILRAPQMAANPAASNCIQLQQLNGLGQEQTQLITIPGTNIQI---------PVTNLIQQQQQAQQ 189
              :.|...|.|        ||.:.| |.||...||..|.:|:         |:...|||.|..||
  Fly   199 --KEPISPAKP--------QQQHSL-QSQTVTPTINPTQLQLQPQLGDQLQPLWQQIQQLQLQQQ 252

  Fly   190 VHQGTVQQQA--------QGTNASGANG----SGVTNSGTAGQ-------------------LPG 223
            :.|.|.|.||        ..|::||.:.    :.|.:|.||.|                   :||
  Fly   253 LQQLTNQLQATTQYSVAQDDTSSSGDSKKPKLNFVLSSPTAPQFTTSMPQFGGSQPQIQLQLMPG 317

  Fly   224 S--ITIPGT-NLQIPTSVAAANGLLGNISNISNLLGGGQ-----SIKLENGQLQMRPQLVQFPAP 280
            |  :|..|| ..|...:.||....|....:.:|||...:     :|:.||
  Fly   318 SGGVTSAGTVPAQTQLNAAALLSSLAGPQSTTNLLSPNKCFLPITIRDEN--------------- 367

  Fly   281 AMPQQQQTVAVQIPVQTANGQTIYQTVHVPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFS 345
               ..||.||                 |:                ..::|.:|:..|:|:..|
  Fly   368 ---SDQQIVA-----------------HI----------------DTKNLVLPTTYQVQMKLQ-- 394

  Fly   346 QIAQIVTPNGQIQQVQLAMPYPQLPPNANIIHIQ-------NPHQQQQQQVQQQQQQQQAQQQQQ 403
              .|:.|.:||        |..||.|.:....:|       ||....|.....|.|....||...
  Fly   395 --PQLATADGQ--------PIMQLTPTSIPATLQLTPQTLGNPGSAFQGTTVTQNQFLAPQQPLT 449

  Fly   404 AQQQQAQQQQQQQVQAQH------QQLLQAISDASAGGQLPPNQPITITNAQGQQLTVIPAQLRP 462
            .....||...||.:::.|      |.:::.:::      :||. |.|.|:::
  Fly   450 QLPNTAQVTSQQIIRSPHTSTTNSQLVIRNVTN------IPPT-PTTPTSSK------------- 494

  Fly   463 NAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQ 527
            .|||..||:|...|.|.........|...          .:|....|   .|::::|| ....||
  Fly   495 KAPTFKTPSPKQKPMPSPKSKTTVGPSSG----------GSNGTSTN---EFKRLITQ-TKPQPQ 545

  Fly   528 VQTQGQVQVMPKQEPQ------------SPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTAS 580
            |:.|....:.....|.            |....||.:.::|          .:.||||.|.|.|
  Fly   546 VKQQQTAGLSASGAPTATSANQAAMQRLSSNTTITKVPKQP----------ASLPAPAPTSNPA- 599

  Fly   581 PQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVN--AVTTS 643
                ::..|:.::.::|.:|:..:.:..:.|  :|.:| ||| :||||||:||.|:..  .:...
  Fly   600 ----KLPMLNKQNITISRISMQTAPKAQSKP--STTSP-TPA-SQPIPVSVPALSQAQPPPLAAQ 656

  Fly   644 STQITIAP-----TGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATG 703
            ..:|...|     |.||             .:::.......:.:|.|.
  Fly   657 HKKIVRKPPENQDTSGQ-------------KVKAARPPQQILPSPQQE----------------- 691

  Fly   704 GGGGTATGEPKPRLKRVACTCPNCTDGEKHSDKKRQHI--------------CHITGCHKVYGKT 754
            |...|.:|...|...  ...||.|    |...||::|:              |...||.|.:.:.
  Fly   692 GQNATHSGSEAPTTS--GLICPTC----KREFKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRK 750

  Fly   755 SHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHT---GEKRFQCQECNKKFMRSDHLS 816
            .||..||..|:|::.:.|.  .|.|.|:|.|.|.:|||.||   .|..:.|..|||.|....|..
  Fly   751 EHLSRHLVSHSGQKMYTCE--VCKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYE 813

  Fly   817 KHIK------------------------THFKSRSGV------ELIELSIKQETKGGNAPKSIST 851
            ||.:                        ||.:|...|      |:.:....|:|:....|..:..
  Fly   814 KHREMHKKIRPESAAPGATASPAAAPALTHVRSNGQVPNKAVFEIKQERSAQQTQTQQPPAQVMH 878

  Fly   852 VNGIVTIEIPGGGSAAAGSGASSVAATVAGSTVTPGG-ATIVQL 894
            |  :.|.::.|          :::..|.|..:..||. |..|||
  Fly   879 V--VTTQDLAG----------NTITITQAPDSNMPGSLANYVQL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	40/142 (28%)
		C2H2 Zn finger	742..764	CDD:275368	8/21 (38%)
		zf-H2C2_2	756..783	CDD:290200	10/26 (38%)
		C2H2 Zn finger	772..794	CDD:275368	10/21 (48%)
		zf-H2C2_2	786..809	CDD:290200	11/25 (44%)
		zf-C2H2	800..822	CDD:278523	8/45 (18%)
		C2H2 Zn finger	802..822	CDD:275368	8/43 (19%)
pad	NP_650534.2	zf-AD	16..87	CDD:214871
		C2H2 Zn finger	710..730	CDD:275368	7/23 (30%)
		zf-C2H2	736..760	CDD:278523	8/23 (35%)
		C2H2 Zn finger	738..760	CDD:275368	8/21 (38%)
		zf-H2C2_2	752..777	CDD:290200	10/26 (38%)
		zf-C2H2	766..788	CDD:278523	10/23 (43%)
		C2H2 Zn finger	768..788	CDD:275368	10/21 (48%)
		zf-H2C2_2	780..808	CDD:290200	12/27 (44%)
		C2H2 Zn finger	799..819	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840