DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spps and SP5

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	XP_011509461.1	Gene:	SP5 / 389058	HGNCID:	14529	Length:	454	Species:	Homo sapiens

Alignment Length:	419	Identity:	142/419 - (33%)
Similarity:	181/419 - (43%)	Gaps:	98/419 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 PNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHP 526
            |.|..|.|.:..|.|.....|:...:|..  |.||.         |..|   |......:|...|
Human    88 PLALLAATCSRIGQPGAAAPPDFLQVPYD--PALGS---------PSRL---FHPWTADMPAHSP 138

  Fly   527 QVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFG-----PISATGNPPAPASTPNTASPQQQQI 586
                    ..:|   |..|:..:|..|.....:||     |::    |||..|.|...||    :
Human   139 --------GALP---PPHPSLGLTPQKTHLQPSFGAAHELPLT----PPADPSYPYEFSP----V 184

  Fly   587 KFLHTESNSLSSLSIPASIQI---TALPQQATN------TPNTPATTQ-----PIPVSLPARSKV 637
            |.|.:...:|.:...||.:..   .|||...:|      .|..|.|.:     |.|..||..|
Human   185 KMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDDLPWWS-- 247

  Fly   638 NAVTTSSTQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAAT 702
                        .|..|        |....:.:..:..|......|.......:.:.|:...||.
Human   248 ------------IPQAG--------AGPGASGVPGSGLSGACAGAPHAPRFPASAAAAAAAAAAL 292

  Fly   703 GGG---GGT----------ATGEPKPRLKRVA-----CTCPNCTDG----EKHSDKKRQHICHIT 745
            ..|   |.:          |..:.|..|...|     |.||||...    |....||:||:||:.
Human   293 QRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVP 357

  Fly   746 GCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFM 810
            ||.|||||||||:||||||||||||||:|.||||.||||||||||.|||||||||.|.||.|:||
Human   358 GCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFM 422

  Fly   811 RSDHLSKHIKTHFKSRSGVELIELSIKQE 839
            |||||:||:|||...:  :::.|..:|:|
Human   423 RSDHLAKHVKTHQNKK--LKVAEAGVKRE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	75/105 (71%)
		C2H2 Zn finger	742..764	CDD:275368	17/21 (81%)
		zf-H2C2_2	756..783	CDD:290200	22/26 (85%)
		C2H2 Zn finger	772..794	CDD:275368	17/21 (81%)
		zf-H2C2_2	786..809	CDD:290200	18/22 (82%)
		zf-C2H2	800..822	CDD:278523	15/21 (71%)
		C2H2 Zn finger	802..822	CDD:275368	14/19 (74%)
SP5	XP_011509461.1	C2H2 Zn finger	357..376	CDD:275368	15/18 (83%)
		COG5048	<367..440	CDD:227381	57/74 (77%)
		zf-H2C2_2	368..395	CDD:290200	22/26 (85%)
		C2H2 Zn finger	384..406	CDD:275368	17/21 (81%)
		zf-H2C2_2	398..421	CDD:290200	18/22 (82%)
		zf-C2H2	412..434	CDD:278523	15/21 (71%)
		C2H2 Zn finger	414..434	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	5.010