DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spps and Sp3

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	XP_038962304.1	Gene:	Sp3 / 367846	RGDID:	1583765	Length:	781	Species:	Rattus norvegicus

Alignment Length:	972	Identity:	252/972 - (25%)
Similarity:	362/972 - (37%)	Gaps:	355/972 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QYKSAASAATSAPPATP----LAAGGSSKATIPPNG-----ASAAA-------------SQTQVH 45
            |:.:.|:||.:|....|    |.|...||...|..|     |:|||             :..|:.
  Rat    39 QHGNGAAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDEEEAAAAAGVPAAAAGATGDLASAQLG 103

  Fly    46 GAP-------GTPT--MQQIINIHQMPPQFAGGAVAGNGQNAGMPQNMFQIVQPMPMQTVNIDGQ 101
            |||       .|||  ..:..|:.|:|     ||...:||..            :|:|  |:..|
  Rat   104 GAPNRWEVLSATPTTIKDEAGNLVQIP-----GAATSSGQYV------------LPLQ--NLQNQ 149

  Fly   102 EAIFI-PNLNAQLATAQAVNFNGQQAFITPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQTQL 165
            :...: |..::...|...|.:.     :.|..|...|.|:......|:     ...|:.||.:|:
  Rat   150 QIFSVAPGSDSSNGTVSNVQYQ-----VIPQIQSTDAQQVQIGFTGSS-----DNGGINQESSQI 204

  Fly   166 ITIPGTNIQI--------PVTNLIQQQQQAQQVHQGTVQQQAQGTNASGANGSGVTN--SGTAGQ 220
            ..|||:|..:        .:.|||.|          |.|.|.||....|::..|.|.  :.....
  Rat   205 QIIPGSNQTLLASGTPPANIQNLIPQ----------TGQVQVQGVAIGGSSFPGQTQVVANVPLG 259

  Fly   221 LPGSIT-IPGTNLQIPTSVAAANGLLGN-------ISNISNLLGGGQSI-KLENGQL---QMRPQ 273
            |||:|| :|..::.:.:.     ||.|:       |:...:|:..||:: ..:|.:.   ::.|.
  Rat   260 LPGNITFVPINSVDLDSL-----GLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPD 319

  Fly   274 LVQFPAPA---MPQQQQTVAVQIPVQTANGQTIYQTVHVPVQAAATSSGGLQNL-MQAQSLQMPS 334
            :.:..|..   :|....:   |:||...:...:.|..:    :..|:||.:.:. :|...:|.|.
  Rat   320 VNETNADTDLFVPTSSSS---QLPVTIDSTGILQQNTN----SLTTTSGQVHSSDLQGNYIQSPV 377

  Fly   335 ASQMQIIPQFSQIAQIVTPNGQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQ 399
            :.:.|     :|..|:.|....:|.:||                    |..||...|.|..|...
  Rat   378 SEETQ-----AQNIQVSTAQPVVQHLQL--------------------QDSQQPTSQAQIVQGIT 417

  Fly   400 QQQ----QAQQQQAQQQQQQQVQAQHQQ---LLQAISDASAGGQLPPN----------QPITITN 447
            .|.    ||..|...||..|.:|.|...   |:|| ...:..||:...          |.:.|.|
  Rat   418 PQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQA-QTVTPSGQITWQTFQVQGVQNLQNLQIQN 481

  Fly   448 AQGQQLTVIPAQL----RPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPP 508
            ...||:|:.|.|.    :..|..|.|..|..:.|. |:||||.:.:.:|...|
  Rat   482 TAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTG-QLPNLQTVTVNSIDSTG------------ 533

  Fly   509 NLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPA 573
                                     :|:.|.:...||..:  .||:|.||
  Rat   534 -------------------------IQLHPGENADSPADI--RIKEEEPD--------------- 556

  Fly   574 STPNTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVN 638
                   |::.|:
  Rat   557 -------PEEWQL---------------------------------------------------- 562

  Fly   639 AVTTSSTQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATG 703
                                                :..:|:.|...:||.:.:....
  Rat   563 ------------------------------------SGDSTLNTNDLTHLRVQVVDEE------- 584

  Fly   704 GGGGTATGEPKPRLKRVACTCPNCTDG---EKHSDKKRQHICHITGCHKVYGKTSHLRAHLRWHT 765
               |....:...||:|||||||||.:|   ..:..||:||||||.||.||||||||||||||||:
  Rat   585 ---GDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHS 646

  Fly   766 GERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSR---- 826
            |||||:|:|.|||||||||||||||||||||||:|.|.||:|:|||||||:||||||...:
  Rat   647 GERPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHS 711

  Fly   827 -------------------SGVELIELSIKQETKGGNAPKSISTVNGIVT--------IEIP 861
                               .|..||..:|:|.:..|     |.|||...|        .|||
  Rat   712 SSTVLASVEAGRDDALITAGGTTLILANIQQGSVSG-----IGTVNASATSNQDILTNTEIP 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	78/127 (61%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:290200	22/26 (85%)
		C2H2 Zn finger	772..794	CDD:275368	19/21 (90%)
		zf-H2C2_2	786..809	CDD:290200	18/22 (82%)
		zf-C2H2	800..822	CDD:278523	16/21 (76%)
		C2H2 Zn finger	802..822	CDD:275368	15/19 (79%)
Sp3	XP_038962304.1	SP3_N	51..622	CDD:411774	162/807 (20%)
		zf-C2H2	621..645	CDD:395048	21/23 (91%)
		C2H2 Zn finger	623..645	CDD:275368	19/21 (90%)
		zf-C2H2	651..675	CDD:395048	20/23 (87%)
		C2H2 Zn finger	653..675	CDD:275368	19/21 (90%)
		zf-H2C2_2	667..690	CDD:404364	18/22 (82%)
		zf-C2H2	681..703	CDD:395048	16/21 (76%)
		C2H2 Zn finger	683..703	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10635
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3237
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46128
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.070