DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spps and Sp2

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	XP_038942006.1	Gene:	Sp2 / 303499	RGDID:	1592078	Length:	636	Species:	Rattus norvegicus

Alignment Length:	847	Identity:	228/847 - (26%)
Similarity:	325/847 - (38%)	Gaps:	279/847 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YKSAASAATSAPPATPLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMPPQFAG 68
            |...|:|||.....:|||...::.:.|.|....||.:..    ||..||.::::.|...|
  Rat    43 YLQPAAAATQDSQPSPLALLAATCSKIGPPAVEAAVTPP----APPQPTPRKLVPIKPAP----- 98

  Fly    69 GAVAGNGQNAGMP----QNMFQIVQPMPMQTVNIDGQEAIFIPNLNAQLATAQAVNFNGQQAFIT 129
                       :|    :|.|.|:.... ..:.|.|          :||:.:..   .||..|..
  Rat    99 -----------LPLSPCKNSFSILSSKG-NILQIQG----------SQLSASYP---GGQFVFAI 138

  Fly   130 PNGQIL------------RAPQMAANPAASNCIQLQQLNGLGQEQTQLITIPGTN--IQIPVTNL 180
            .|..::            :.||:..|  :|..||:|.     ....|:..|||||  |..|.|:
  Rat   139 QNPTLINKGSRSNASIQYQVPQIQGN--SSQTIQVQP-----NLTNQIQIIPGTNQAIITPSTS- 195

  Fly   181 IQQQQQAQQVHQGTVQQQAQGTN--ASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANG 243
               ..:...:....||:....|.  .||||...:|..|      |::|     |.:|
  Rat   196 ---GHKPVPIKPAPVQKSNTTTTPVQSGANVVKLTGGG------GNMT-----LTLP-------- 238

  Fly   244 LLGNISNISNLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQQQQTVAVQIPVQTANGQTIYQTVH 308
             |.|:.|.|: :|....:..|:....:.....:....::|..|.:|||...|:|...:|..:.:
  Rat   239 -LNNLVNTSD-IGAPAQLLTESPPTPLSKTNKKARKKSLPVSQPSVAVAEQVETVLIETTAENI- 300

  Fly   309 VPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQIAQIVTPNGQIQQVQLAMPYPQLPPNA 373
              :||.       .||:..||   |...|..:                :||||:      :||.|
  Rat   301 --IQAG-------NNLLIVQS---PGGGQPAV----------------VQQVQV------VPPKA 331

  Fly   374 NIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQAISDASAGGQLP 438
                                                   :||||....||.|:.:..|||.....
  Rat   332 ---------------------------------------EQQQVVQIPQQALRVVQAASATLPTV 357

  Fly   439 PNQPITITNAQGQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHA 503
            |.:|     :|..|:..          |.|||....:.||.                |:||.:..
  Rat   358 PQKP-----SQNFQIQT----------TEPTPTQVYIRTPS----------------GEVQTVLV 391

  Fly   504 NQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGN 568
            ...||...|....|    ..|.|.::.       |.....|.......:::|
  Rat   392 QDSPPATAATTSTV----SCSSPALRA-------PHLSGSSKKHSAAILRKE------------- 432

  Fly   569 PPAPASTPNTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPA 633
            .|.|...|                :.|:.||:   :.|:.| ..||..|.|
  Rat   433 RPLPKIAP----------------AGSIISLN---AAQLAA-AAQAMQTIN-------------- 463

  Fly   634 RSKVNAVTTSSTQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVG 698
               :|.|......:||..||||        :..|....|.|..|.:..:|:|..|.|..::|
  Rat   464 ---INGVQVQGVPVTITNTGGQ--------QQLTVQNVSGNNLTISGLSPTQIQLQMEQALA--- 514

  Fly   699 GAATGGGGGTATGEPKP--RLKRVACTCPNCTDGEKHSDK--KRQHICHITGCHKVYGKTSHLRA 759
                        ||.:|  :.:|:|||||||.||||.|.:  |::|:|||..|.|.:.|||.|||
  Rat   515 ------------GEAQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRA 567

  Fly   760 HLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFK 824
            |:|.|||||||||:|.|||||||||||||||.|||||:|||:|.:|.|:|||||||:||.|||..
  Rat   568 HVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLG 632

  Fly   825 SR 826
            ::
  Rat   633 TK 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	71/104 (68%)
		C2H2 Zn finger	742..764	CDD:275368	13/21 (62%)
		zf-H2C2_2	756..783	CDD:290200	21/26 (81%)
		C2H2 Zn finger	772..794	CDD:275368	18/21 (86%)
		zf-H2C2_2	786..809	CDD:290200	16/22 (73%)
		zf-C2H2	800..822	CDD:278523	14/21 (67%)
		C2H2 Zn finger	802..822	CDD:275368	13/19 (68%)
Sp2	XP_038942006.1	SP2_N	33..549	CDD:411776	166/760 (22%)
		C2H2 Zn finger	553..572	CDD:275368	10/18 (56%)
		zf-H2C2_2	565..591	CDD:404364	21/25 (84%)
		C2H2 Zn finger	580..602	CDD:275368	18/21 (86%)
		zf-H2C2_2	594..617	CDD:404364	16/22 (73%)
		zf-C2H2	608..630	CDD:395048	14/21 (67%)
		C2H2 Zn finger	610..630	CDD:275368	13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3237
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.070