DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spps and Sp5

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001100022.1	Gene:	Sp5 / 296510	RGDID:	1308499	Length:	398	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	140/411 - (34%)
Similarity:	185/411 - (45%)	Gaps:	82/411 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 PNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHP 526
            |.|..|.|.:..|.|.....|:...:|..  |.||.         |..|   |......:|...|
  Rat    32 PLALLAATCSRIGQPGAAAAPDFLQVPYD--PALGS---------PSRL---FHPWTADMPAHSP 82

  Fly   527 QVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFG-----PISATGNPPAPASTPNTASPQQQQI 586
                    ..:|   |..|:..:|..|.....:||     |::    |||..|.|...||    :
  Rat    83 --------GALP---PPHPSLGLTPQKTHLQPSFGAAHELPLT----PPADPSYPYEFSP----V 128

  Fly   587 KFLHTESNSLSSLSIPASIQI---TALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQIT 648
            |.|.:...:|.:...||.:..   .|||...:|....|....|.|              :..|::
  Rat   129 KMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPP--------------TCRQLS 179

  Fly   649 IAPTGGQVVSVTTQARGA---TASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGG---GG 707
            .||....:...:....||   ::.:..|:.|:.....|.......:.:.|:...||...|   |.
  Rat   180 PAPAPDDLPWWSIPQSGAGPGSSGVPGTSLSSACAGPPHAPRFPASAAAAAAAAAALQRGLVLGP 244

  Fly   708 T----------ATGEPKPRLKRVA-----CTCPNCTDG----EKHSDKKRQHICHITGCHKVYGK 753
            :          |..:.|..|...|     |.||||...    |....||:||:||:.||.|||||
  Rat   245 SDFAQYQSQIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGK 309

  Fly   754 TSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKH 818
            ||||:||||||||||||||:|.||||.||||||||||.|||||||||.|.||.|:|||||||:||
  Rat   310 TSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKH 374

  Fly   819 IKTHFKSRSGVELIELSIKQE 839
            :|||...:  :::.|..:|:|
  Rat   375 VKTHQNKK--LKVAEAGVKRE 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	75/105 (71%)
		C2H2 Zn finger	742..764	CDD:275368	17/21 (81%)
		zf-H2C2_2	756..783	CDD:290200	22/26 (85%)
		C2H2 Zn finger	772..794	CDD:275368	17/21 (81%)
		zf-H2C2_2	786..809	CDD:290200	18/22 (82%)
		zf-C2H2	800..822	CDD:278523	15/21 (71%)
		C2H2 Zn finger	802..822	CDD:275368	14/19 (74%)
Sp5	NP_001100022.1	SP1-4_N	31..>47	CDD:425404	5/14 (36%)
		SP5_N	106..297	CDD:412096	47/212 (22%)
		C2H2 Zn finger	301..320	CDD:275368	15/18 (83%)
		COG5048	<311..384	CDD:227381	57/74 (77%)
		C2H2 Zn finger	328..350	CDD:275368	17/21 (81%)
		zf-H2C2_2	342..365	CDD:404364	18/22 (82%)
		C2H2 Zn finger	358..378	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46128
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020