DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spps and ace2

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_594109.1	Gene:	ace2 / 2541661	PomBaseID:	SPAC6G10.12c	Length:	533	Species:	Schizosaccharomyces pombe

Alignment Length:	472	Identity:	101/472 - (21%)
Similarity:	160/472 - (33%)	Gaps:	150/472 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 DASAGGQLPPNQPIT------------------ITNAQ-------------------GQQLTVIP 457
            |||..   ||:.|:|                  :||:|                   .||:...|
pombe   114 DASLS---PPSSPLTCVSQIHTEQNFNNNDAFSLTNSQQAFSEIGYDASNWIDELDSQQQVLSFP 175

  Fly   458 A---------------------QLRPNAPTAPTPAPAGVPTPMQMPNLQA---LPIQNIPGLGQV 498
            .                     .|..:.|....||.:.:|:..|:.:...   || .:.|||.::
pombe   176 EFDIPEIKTETCSNKDHLENFDYLSSSIPETSGPASSVLPSSSQLESFNEFMFLP-SSPPGLDEI 239

  Fly   499 QIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPI 563
                 |..|.....|||  ::|...:||  ......:..|...|.||...:  :|.||.
pombe   240 -----NGAPSFEELNFQ--ISQPSPAHP--VDLSSPETAPNISPVSPFAQL--VKLEPT------ 287

  Fly   564 SATGNPPAPASTPNTASPQQQQIKFLHTES-NSLSSLSIPA----------SIQITALPQQATNT 617
                :|..|:...:::.......:  ||:: .:.:.||.||          |:....|.....|.
pombe   288 ----SPQKPSFALDSSFSHLDVCR--HTDNQKAFAKLSSPAEYVSEFEKFSSVCDHGLDISNANI 346

  Fly   618 PNTPATTQPIPVSLPARS-----KVNAVTTSSTQITIAPTGGQVVSVTTQARGATASIRSTNTST 677
            .||  .||...:|.|..|     |.....|...:..:||                 .|.|.:.|.
pombe   347 NNT--LTQQFALSAPYESCIVTKKPEPCITVKEEEQLAP-----------------KIESADLSI 392

  Fly   678 TTITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKPRLKRV------ACTCPNCTDGEKHSDK 736
            |...|...|...:.||.          .....|.:...|:.|:      :..|....||
pombe   393 TPQVTEHDSKPPVRISY----------DHRCKTRKQSTRICRIPPETMASLYCGPEADG------ 441

  Fly   737 KRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQ 801
              :::|...||:|...:..::.:|::.|..:||:.|.  .|...|.|..:|:||.|.|...:.:.
pombe   442 --KYVCLYNGCNKRIARKYNVESHIQTHLSDRPYRCD--LCKAGFVRHHDLKRHLRIHENGRPYV 502

  Fly   802 CQECNKKFMRSDHLSKH 818
            | ||.|:|.|.|.|::|
pombe   503 C-ECLKRFNRLDALNRH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	28/94 (30%)
		C2H2 Zn finger	742..764	CDD:275368	5/21 (24%)
		zf-H2C2_2	756..783	CDD:290200	7/26 (27%)
		C2H2 Zn finger	772..794	CDD:275368	8/21 (38%)
		zf-H2C2_2	786..809	CDD:290200	9/22 (41%)
		zf-C2H2	800..822	CDD:278523	9/19 (47%)
		C2H2 Zn finger	802..822	CDD:275368	9/17 (53%)
ace2	NP_594109.1	COG5048	45..518	CDD:227381	100/470 (21%)
		C2H2 Zn finger	448..467	CDD:275368	4/18 (22%)
		zf-C2H2	473..495	CDD:278523	8/23 (35%)
		C2H2 Zn finger	475..495	CDD:275368	8/21 (38%)
		zf-H2C2_2	487..511	CDD:290200	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030