DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spps and Sp1

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_036787.2	Gene:	Sp1 / 24790	RGDID:	3738	Length:	786	Species:	Rattus norvegicus

Alignment Length:	995	Identity:	279/995 - (28%)
Similarity:	363/995 - (36%)	Gaps:	348/995 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMPPQFAGGAVAGNGQNAGMPQNMFQI 87
            |||.      ||..||.|||:......:.:              :||   |.||.:
  Rat    25 GGSG------NGGGAAFSQTRSSSTGSSSS--------------SGG---GGGQES--------- 57

  Fly    88 VQPMPMQTVNIDGQEAIFIPNLNAQ----------------LATAQAVNFNGQQAFITPNGQILR 136
             ||.|:..:...... |..||.|:.                .||..:...||.|...:.:|....
  Rat    58 -QPSPLALLAATCSR-IESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPT 120

  Fly   137 APQMAANPA-ASNCIQLQQLNGLGQEQTQLITIPGTNIQIPVTNLIQQQQ------------QAQ 188
            :.:.:.|.. .||          |.|.::..|:.|....:..|..:|.||            |.|
  Rat   121 SKEQSGNSTNGSN----------GSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQ 175

  Fly   189 QVHQ-GTVQ-QQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANGLLGNISNI 251
            .:.| .||. ||.|    ..|.|:.|...| :||:.   .|||.|.||                |
  Rat   176 VIPQFQTVDGQQLQ----FAATGAQVQQDG-SGQIQ---IIPGANQQI----------------I 216

  Fly   252 SNLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQ-QQQTVAVQ-IPVQTANGQTIYQTVHVPV--- 311
            :|...||..|                  .|||. .||.|.:| :.....:|||.|.| :|||
  Rat   217 TNRGSGGNII------------------AAMPNLLQQAVPLQGLANNVLSGQTQYVT-NVPVALN 262

  Fly   312 --------------------QAAATSSGGLQ----------NLMQAQSLQMPSASQMQIIPQFSQ 346
                                ||...||.|.|          ..:.:.||....||........:.
  Rat   263 GNITLLPVNSVSAATLTPSSQAGTISSSGSQESGSQPVTSGTAISSASLVSSQASSSSFFTNANS 327

  Fly   347 IAQIVT-------------PNGQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQA 398
            .:...|             .:|...|.|.:.....| ..::.::||          |.|......
  Rat   328 YSTTTTTSNMGIMNFTSSGSSGTSSQGQTSQRVGGL-QGSDSLNIQ----------QNQTSGGSL 381

  Fly   399 QQQQQAQQQQAQQQQQQQVQAQHQ-----QLLQAISDASAGGQLPPNQPITITNAQGQQLTVI-- 456
            |..||.:.:|:||.||||:..|.|     |.|||:..|...||....|.|:....|..||..:
  Rat   382 QGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQN 446

  Fly   457 --PAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLT 519
              |..:|     .||..|.|      ..:.|.|.:||:    |||...|            |.:|
  Rat   447 SGPIIIR-----TPTVGPNG------QVSWQTLQLQNL----QVQNPQA------------QTIT 484

  Fly   520 QLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTAS---- 580
            ..||       ||   |...|...|.|            |..||::..:.||...|.|.|.
  Rat   485 LAPM-------QG---VSLGQTSSSNT------------TLTPIASAASIPAGTVTVNAAQLSSM 527

  Fly   581 PQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSST 645
            |..|.|        :||:|. .:.||:..||.......|||.                   ....
  Rat   528 PGLQTI--------NLSALG-TSGIQVHQLPGLPLAIANTPG-------------------DHGA 564

  Fly   646 QITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGTAT 710
            |:.:...||..:...|                                        .||..|..:
  Rat   565 QLGLHGPGGDGIHDET----------------------------------------AGGEEGENS 589

  Fly   711 GEPKP----RLKRVACTCPNCTDGEKHSD----KKRQHICHITGCHKVYGKTSHLRAHLRWHTGE 767
            .:|:|    |.:|.|||||.|.|.|....    ||:||||||.||.|||||||||||||||||||
  Rat   590 PDPQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGE 654

  Fly   768 RPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELI 832
            |||:|:|::||||||||||||||:|||||||:|.|.||.|:||||||||||||||
  Rat   655 RPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTH---------- 709

  Fly   833 ELSIKQETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSGASSVAAT---VAGSTVTPGGAT---- 890
                 |..|||   ..::...|.:.:: .|.||..:|:...|...|   ||...:.|.|..
  Rat   710 -----QNKKGG---PGVALSVGTLPLD-SGAGSEGSGTATPSALITTNMVAMEAICPEGIARLAN 765

  Fly   891 -------IVQLPTVEASGGG 903
                   :.:|.::..||.|
  Rat   766 SGINVMQVTELQSINISGNG 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	78/105 (74%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:290200	22/26 (85%)
		C2H2 Zn finger	772..794	CDD:275368	17/21 (81%)
		zf-H2C2_2	786..809	CDD:290200	17/22 (77%)
		zf-C2H2	800..822	CDD:278523	17/21 (81%)
		C2H2 Zn finger	802..822	CDD:275368	16/19 (84%)
Sp1	NP_036787.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		22/102 (22%)
		Repressor domain. /evidence=ECO:0000250	2..83		22/91 (24%)
		SP1-4_N	55..628	CDD:425404	175/764 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..143		6/42 (14%)
		Transactivation domain A (Gln-rich). /evidence=ECO:0000250	147..252		38/146 (26%)
		Transactivation domain B (Gln-rich). /evidence=ECO:0000250	262..496		64/281 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..303		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..397		15/75 (20%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P08047	463..471		2/7 (29%)
		Transactivation domain C (highly charged). /evidence=ECO:0000250	497..611		39/193 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..600		9/77 (12%)
		VZV IE62-binding. /evidence=ECO:0000250	620..786		93/185 (50%)
		zf-C2H2	627..651	CDD:395048	21/23 (91%)
		C2H2 Zn finger	629..651	CDD:275368	19/21 (90%)
		zf-H2C2_2	643..670	CDD:404364	22/26 (85%)
		C2H2 Zn finger	659..681	CDD:275368	17/21 (81%)
		zf-H2C2_2	673..696	CDD:404364	17/22 (77%)
		zf-C2H2	687..709	CDD:395048	17/21 (81%)
		C2H2 Zn finger	689..709	CDD:275368	16/19 (84%)
		Domain D. /evidence=ECO:0000250	709..786		20/96 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345163
Domainoid	1	1.000	49	1.000	Domainoid score	I11480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3237
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46128
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.000