DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spps and SP8

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_874359.2	Gene:	SP8 / 221833	HGNCID:	19196	Length:	508	Species:	Homo sapiens

Alignment Length:	296	Identity:	120/296 - (40%)
Similarity:	144/296 - (48%)	Gaps:	80/296 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 PNTPATTQPIPVSL-PARSKVNAVTTSSTQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTIT 681
            ||:.|.   :|.|| ||...:.....|       |.||    ..:...|.:.|..|:..| :.:.
Human   241 PNSAAA---LPGSLHPAAGGLQTSLHS-------PLGG----YNSDYSGLSHSAFSSGAS-SHLL 290

  Fly   682 TPSQSHL--------------NMNISVASVGGAATGGG-----GGTATGEPKPRLKRVACTCPNC 727
            :|:..||              :....:|..||:....|     ||:.....:....|..|.||||
Human   291 SPAGQHLMDGFKPVLPGSYPDSAPSPLAGAGGSMLSAGPSAPLGGSPRSSARRYSGRATCDCPNC 355

  Fly   728 TDGEKHSD------KKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDE 786
            .:.|:...      :|..|.|||.||.|||||||||:||||||||||||||:|.|||||||||||
Human   356 QEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDE 420

  Fly   787 LQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKGGNAPKSIST 851
            ||||.|||||||||.|..|||:||||||||||:|||    ||             ||.
Human   421 LQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTH----SG-------------GGG------- 461

  Fly   852 VNGIVTIEIPGGGSAAAGSGASSVAAT-----VAGS 882
                      |||||.:|||....:.|     .|||
Human   462 ----------GGGSAGSGSGGKKGSDTDSEHSAAGS 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	76/107 (71%)
		C2H2 Zn finger	742..764	CDD:275368	18/21 (86%)
		zf-H2C2_2	756..783	CDD:290200	23/26 (88%)
		C2H2 Zn finger	772..794	CDD:275368	18/21 (86%)
		zf-H2C2_2	786..809	CDD:290200	18/22 (82%)
		zf-C2H2	800..822	CDD:278523	16/21 (76%)
		C2H2 Zn finger	802..822	CDD:275368	15/19 (79%)
SP8	NP_874359.2	C2H2 Zn finger	379..398	CDD:275368	15/18 (83%)
		COG5048	<389..456	CDD:227381	57/66 (86%)
		zf-H2C2_2	390..417	CDD:290200	23/26 (88%)
		C2H2 Zn finger	406..428	CDD:275368	18/21 (86%)
		zf-H2C2_2	420..443	CDD:290200	18/22 (82%)
		zf-C2H2	434..456	CDD:278523	16/21 (76%)
		C2H2 Zn finger	436..456	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010