DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spps and KLF14

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_619638.2	Gene:	KLF14 / 136259	HGNCID:	23025	Length:	323	Species:	Homo sapiens

Alignment Length:	359	Identity:	108/359 - (30%)
Similarity:	152/359 - (42%)	Gaps:	110/359 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   552 IKQEPPDTFGPISATGN---------------PPAPASTPNT------------ASPQQQQIKFL 589
            :.:.|||..|...|.|:               ||.|||.|..            |:|.
Human    25 VHRRPPDPEGAGGAAGSEVGAAPPESALPGPGPPGPASVPQLPQVPAPSPGAGGAAPH------- 82

  Fly   590 HTESNSLSSLSIPASIQITALPQQATNTPNTPAT----TQPIPVSLPARSKVNAVTTSSTQITIA 650
                  |.:.|:.|.::.::......|:...|..    :.|||.|         |.|..::  :|
Human    83 ------LLAASVWADLRGSSGEGSWENSGEAPRASSGFSDPIPCS---------VQTPCSE--LA 130

  Fly   651 PTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGG-AATGGGGGTATG--- 711
            |..|            .|::.:..:|:.....||        :.|:.|. ||:||..|.|.|
Human   131 PASG------------AAAVCAPESSSDAPAVPS--------APAAPGAPAASGGFSGGALGAGP 175

  Fly   712 ----EPKPRLKRVACTCPNCTDGEKHSDKKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVC 772
                :..||.:.|             :...::|.|...||.|.|.|:|||::|.|.|||||||.|
Human   176 APAADQAPRRRSV-------------TPAAKRHQCPFPGCTKAYYKSSHLKSHQRTHTGERPFSC 227

  Fly   773 SWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIK 837
            .|..|.|:|||||||.||.|||||||||.|..|.|:|.|||||:||.:.|  .....::||...:
Human   228 DWLDCDKKFTRSDELARHYRTHTGEKRFSCPLCPKQFSRSDHLTKHARRH--PTYHPDMIEYRGR 290

  Fly   838 QETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSG 871
            :.|...:.|         :|.|:.   |:|:|||
Human   291 RRTPRIDPP---------LTSEVE---SSASGSG 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	53/101 (52%)
		C2H2 Zn finger	742..764	CDD:275368	11/21 (52%)
		zf-H2C2_2	756..783	CDD:290200	16/26 (62%)
		C2H2 Zn finger	772..794	CDD:275368	14/21 (67%)
		zf-H2C2_2	786..809	CDD:290200	16/22 (73%)
		zf-C2H2	800..822	CDD:278523	12/21 (57%)
		C2H2 Zn finger	802..822	CDD:275368	11/19 (58%)
KLF14	NP_619638.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..80		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..116		2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..161		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..195		6/41 (15%)
		COG5048	198..>283	CDD:227381	51/86 (59%)
		C2H2 Zn finger	200..219	CDD:275368	10/18 (56%)
		C2H2 Zn finger	227..249	CDD:275368	14/21 (67%)
		C2H2 Zn finger	257..277	CDD:275368	11/19 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..323		11/46 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910