DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spps and SP7

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001166938.1	Gene:	SP7 / 121340	HGNCID:	17321	Length:	431	Species:	Homo sapiens

Alignment Length:	511	Identity:	154/511 - (30%)
Similarity:	190/511 - (37%)	Gaps:	190/511 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 SDASAGGQLPPNQPITITNAQGQQLTVIPAQLRPNAPTAPT--------------PAPAGVPTP- 478
            ||.||...:....|...|:..|   .:.||    .:|.|||              |.|.|...|
Human    52 SDLSASKTMGDAYPAPFTSTNG---LLSPA----GSPPAPTSGYANDYPPFSHSFPGPTGTQDPG 109

  Fly   479 MQMPN-----------LQALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPM--SHP---- 526
            :.:|.           ..:|.:.:..|......|||...|.  |.|     |..|.  .||
Human   110 LLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPG--PGN-----TPTPWWDMHPGGNW 167

  Fly   527 ----QVQ---TQGQVQVMPKQEPQSPTQMITSIKQEP--PDTFGPISATGNPPAPASTPNTASPQ 582
                |.|   .||.:...|.|.|.:|        |.|  |..|.|::     |||...|:...|.
Human   168 LGGGQGQGDGLQGTLPTGPAQPPLNP--------QLPTYPSDFAPLN-----PAPYPAPHLLQPG 219

  Fly   583 QQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQI 647
            .|.:                       |||..                    .|..||..|
Human   220 PQHV-----------------------LPQDV--------------------YKPKAVGNS---- 237

  Fly   648 TIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGTATGE 712
                  ||:     :..|.....|.                      ||.||  :||.||:..|
Human   238 ------GQL-----EGSGGAKPPRG----------------------ASTGG--SGGYGGSGAG- 266

  Fly   713 PKPRLKRVACTCPNCTDGEKHS------DKKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFV 771
                  |.:|.||||.:.|:..      .||..|.|||.||.|||||.|||:|||||||||||||
Human   267 ------RSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFV 325

  Fly   772 CSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSI 836
            |:|.||||||||||||:||.||||.||:|.|..|:|:|.||||||||.:||.:...|
Human   326 CNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPG-------- 382

  Fly   837 KQETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSGASSV---AATVAGSTVTPGGA 889
                ...:.||.:            |.|.:.....||..   :|:.|.....|||:
Human   383 ----PPPSGPKEL------------GEGRSTGEEEASQTPRPSASPATPEKAPGGS 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	70/107 (65%)
		C2H2 Zn finger	742..764	CDD:275368	17/21 (81%)
		zf-H2C2_2	756..783	CDD:290200	23/26 (88%)
		C2H2 Zn finger	772..794	CDD:275368	17/21 (81%)
		zf-H2C2_2	786..809	CDD:290200	14/22 (64%)
		zf-C2H2	800..822	CDD:278523	13/21 (62%)
		C2H2 Zn finger	802..822	CDD:275368	12/19 (63%)
SP7	NP_001166938.1	PHA03247	<14..249	CDD:223021	59/281 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..56		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..115		12/50 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..260		39/200 (20%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	156..164		2/7 (29%)
		C2H2 Zn finger	299..318	CDD:275368	14/18 (78%)
		zf-H2C2_2	310..337	CDD:372612	23/26 (88%)
		C2H2 Zn finger	326..348	CDD:275368	17/21 (81%)
		zf-H2C2_2	340..365	CDD:372612	15/24 (63%)
		C2H2 Zn finger	356..376	CDD:275368	12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..431		20/80 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010