Protein Alignment Spps and KLF18

DIOPT Version :10

• Sequence 1: NP_001262902.1
• Gene: Spps / 42882
• FlyBaseID: FBgn0039169
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_001345367.1
• Gene: KLF18 / 105378952
• HGNCID: 51793
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 1028
• Identity: 223/1028 - (21%)
• Similarity: 332/1028 - (32%)
• Gaps: 297/1028 - (28%)

  Fly     3 QYKSAASA----ATSAPPATPLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMP 63
            |.|..|.:    .|..|.::|.   ...|.||..:..:.:...:|::    ||:..|.:|..|:|
Human   108 QVKHTAGSQMTDVTVTPKSSPT---DCQKTTITASNMTISNESSQLN----TPSSDQTLNESQIP 165

  Fly    64 PQFAGGAVAG-------NGQNAGMPQNMFQIVQPMP----------------MQTVNID---GQE 102
                  |:.|       :.|.....|..|...|.:.                ..|.::|   ||.
Human   166 ------ALLGDQMKTLSDNQTLCGDQVTFSSDQTLTDGHTVTSGSDETLSGGQMTTSLDLYGGQM 224

  Fly   103 AIFIPN--LNAQLATAQAVN--FNGQQAFITPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQT 163
            ...|.|  |..:..|..:.|  |.|:|...:...|.|...||..:...      |.|.| ||..|
Human   225 MTSIDNQTLCGEQMTTSSGNQAFYGRQMTTSTGNQTLCGEQMTTSTGN------QALYG-GQMTT 282

  Fly   164 QLI--TIPGTNIQIPVTNLIQQQQQAQQVHQGTVQQQ---AQGTNASG----ANGSGVTNSGTA- 218
            ...  |:.|..:....:|   |....:||...|..|.   .|.|.::|    ..|..:|::|..
Human   283 SASNQTLCGEQMTTSTSN---QTLCGEQVMTSTGNQALCGGQMTTSTGNQNLYGGQMMTSTGNQT 344

  Fly   219 ---GQLPGSITIPGT-NL---QIPTSV---AAANGLLGNISNISNLLGGGQSIKLENGQLQMRPQ 273
               ||:   :|..|. ||   |:.||.   |...|.:...:...||.||.......|..|.....
Human   345 LYWGQM---MTSTGNQNLCGEQVMTSTGNQALCGGQMTTSTGNQNLYGGQMMTSTGNQTLYWGQM 406

  Fly   274 LVQFPAPAMPQQQQTVAVQIPVQTAN-----GQTIYQTVHVPVQAAATSSGGLQNLMQAQSLQMP 333
            :..      ...|.....|:...|.|     ||             .|:|.|.|||...|  .|.
Human   407 MTS------TGNQNLCGEQVMTSTGNQALCGGQ-------------MTTSTGNQNLCGEQ--VMT 450

  Fly   334 SASQMQIIPQFSQIA---------QIVTPNGQ--IQQVQL-------AMPYPQL---PPNANIIH 377
            |.|...:..:.:..:         |:.|..|.  :...|:       .:.:.|:   ..|.|:.
Human   451 STSNQTLCGEQTTTSTSNQTLCGEQVTTSTGNQALYGGQMMTSTGNQTLYWGQMMTSTGNQNLC- 514

  Fly   378 IQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQAISDASAGGQ-LPPNQ 441
                  .:|.......|.....|...:...|....:|......:|.|.......|.|.| |...|
Human   515 ------GEQMTTSTGNQALYGGQMTTSTSNQTLCGEQMTTPTSNQTLCGEQVTTSTGNQALYGGQ 573

  Fly   442 PITITNAQ---GQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHA 503
            ..|.|:.|   |:|:|.          :.......|........|......|.:...|. |.::.
Human   574 ITTSTSNQTLCGEQMTT----------STSNQTLCGEQVTTSTGNQALYGGQMMTSTGN-QALYG 627

  Fly   504 NQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQS--PTQMITSIKQEPPDTFGPISAT 566
            .|:..:  |:.|.:..:...:....||..:.|||.....|:  ..||.||              |
Human   628 GQMTTS--ASNQTLCGEQMTTSTSNQTLCEEQVMTSTGNQALCGEQMTTS--------------T 676

  Fly   567 GNPPAPASTPNTASPQQQQIKFLHTESNSLSSL---SIPASIQITAL----------------PQ 612
            ||.........|::..|.......|.|.|..:|   .:..|....||                .|
Human   677 GNQALYGGQMTTSTSNQTLCGEQTTTSTSNQTLCGEQVTTSTGNQALYGGQMMTSTGNQTLYWGQ 741

  Fly   613 QATNTPNTPATTQPIPVSLPARSKVNAVTTSST--------QITIAPTGGQVV---SVTTQARGA 666
            ..|:|.|.....:.:..|...::......|:||        |:| .||..|.:   .||| :.|.
Human   742 MMTSTGNQNLCGEQMTTSTGNQALYGGQMTTSTSNQTLCGEQMT-TPTSNQTLCGEQVTT-STGN 804

  Fly   667 TASIR---STNTSTTTI-------TTPSQSHLNMNISVASVGGAATGGGGGTATGEPK------- 714
            .|..|   :|:||..|:       :|.:|:.....::.::...|..||...|:||...
Human   805 QALYRGQITTSTSNQTLCGEQMTTSTSNQTLCGEQVTTSTGNQALYGGQMMTSTGNQNLYGGQNM 869

  Fly   715 ----------------------------------------------------------------- 714
                                                                             
Human   870 TSTDNQALYGGQMATYSGNQTLYGDQMLTLQVGNMTTLTDDHSLYGGYMMSHQFSSLPYPGFLCF 934

  Fly   715 ----------PRLKRVACTCPNCTDGEKHSDKKRQHICHITGCHKVYGKTSHLRAHLRWHTGERP 769
                      |:.|..:|      ...|:.:..|.::|....|...|.|..|||.|:|.||||:|
Human   935 SSSHLIQGQLPKQKTQSC------QFWKNPEVSRPYVCTYEDCKMSYSKACHLRTHMRKHTGEKP 993

  Fly   770 FVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTH 822
            :||....|..:|.|||||.||::.||||:.:.|..|:|.|.|||||.:|.|.|
Human   994 YVCDVEGCTWKFARSDELNRHKKRHTGERPYLCSICSKNFARSDHLKQHAKVH 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	SP1-4_N	<281..>371	CDD:425404	21/115 (18%)
		Atrophin-1	284..>630	CDD:460830	75/396 (19%)
		SP1-4_N	<713..741	CDD:425404	5/109 (5%)
		C2H2 Zn finger	742..764	CDD:275368	9/21 (43%)
		zf-H2C2_2	756..783	CDD:463886	14/26 (54%)
		C2H2 Zn finger	772..794	CDD:275368	10/21 (48%)
		zf-H2C2_2	786..809	CDD:463886	11/22 (50%)
		zf-C2H2	800..822	CDD:395048	11/21 (52%)
		C2H2 Zn finger	802..822	CDD:275368	11/19 (58%)
KLF18	NP_001345367.1	KLF18_N	100..384	CDD:410566	69/301 (23%)
		KLF18_N	272..580	CDD:410566	74/348 (21%)
		KLF18_N	650..960	CDD:410566	57/331 (17%)
		C2H2 Zn finger	969..988	CDD:275368	8/18 (44%)
		zf-H2C2_2	980..1007	CDD:463886	14/26 (54%)
		C2H2 Zn finger	996..1018	CDD:275368	10/21 (48%)
		zf-H2C2_2	1010..1035	CDD:463886	12/24 (50%)
		C2H2 Zn finger	1026..1046	CDD:275368	11/19 (58%)