DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spps and sp4

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	XP_002933342.2	Gene:	sp4 / 100494434	XenbaseID:	XB-GENE-983118	Length:	775	Species:	Xenopus tropicalis

Alignment Length:	951	Identity:	287/951 - (30%)
Similarity:	385/951 - (40%)	Gaps:	269/951 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSAASAATSAPPATPLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMP------ 63
            |..||.:..:.| :|||...::.:.|...|.:..|.|.|:...|.    |.::.:...|
Frog    24 KGKASGSQDSQP-SPLALLAATCSKIGTTGENQGAGQQQIIIDPS----QGLVQLQNQPQQLELV 83

  Fly    64 -PQFAGGAVAGNGQNAGMPQNMFQIVQPM-PMQTVNIDGQEAIFIPNLNAQLATAQAVNFNGQQA 126
             .|.||.|              :|||... |:...|...|:.:.|     ..:||.:.:.|.:.|
Frog    84 TTQLAGSA--------------WQIVAAAPPVSKENNITQQGVAI-----AASTAASSSINSENA 129

  Fly   127 FITPNGQILRAPQMAAN-PAASNCIQLQQLNGLGQEQT--QLITIPGTNIQIPVTNLIQQQQQAQ 188
            ..|.:     .|..||. |.....||:|...|..|.|.  |:.|:.|.:|||...|     ..|.
Frog   130 SPTKS-----KPSNAATAPGQFQVIQVQTPGGNVQYQVIPQIQTVEGQHIQISPGN-----TTAL 184

  Fly   189 QVHQGTVQQQAQGTNASGANGSGVTNSGT------AGQL------PG-SI-----TIPGTNLQIP 235
            |..||.:|....|.|.:.......|.||.      |.|.      || ||     ||||...|:.
Frog   185 QDLQGQIQFIPAGNNQAIITAGNRTASGNIIAQNLANQTVPVQIRPGVSIPLQLQTIPGAPAQVV 249

  Fly   236 TSVAAANGLLGNISNISNLL--------GGG--QSIKLENGQLQMRPQLVQFP-----APAMPQQ 285
            |::..      ||..::..|        |||  |.::..:|.:....||:..|     ...||:.
Frog   250 TTLPI------NIGGVTLALPVINSMPAGGGSAQIVQPTDGGVSNGNQLLSTPITTSSVSTMPES 308

  Fly   286 QQTVAVQIPVQTANGQTIYQTVHVPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQIAQI 350
                    |..:::     .|....|.|..|||..|.:..:.......|||           |:.
Frog   309 --------PSSSSS-----STCTTTVSATLTSSDTLVSSAETNQYTSTSAS-----------AER 349

  Fly   351 VTPNGQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQQ------AQQQQA 409
            .|              .:.|.:......|:.:|.|...:|...:|..:.||.|      .||.|.
Frog   350 NT--------------EESPSSVTDGEAQSSNQLQSNGLQNMSEQSNSLQQVQIVGQPVLQQIQI 400

  Fly   410 QQQQQQQVQAQHQQLLQAISDASAGGQLPPNQPITITNAQGQQLTVIPAQLRPNAPT-----APT 469
            ||.|||.:||..||..|..|     ||       ||...|.|||..:  ||:..:||     |||
Frog   401 QQPQQQIIQAIPQQSFQLQS-----GQ-------TIQTLQQQQLQNV--QLQALSPTQVLIRAPT 451

  Fly   470 PAPAGVPTPMQMPNLQALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQV 534
            ..|:|      ..:.|.:.:|||..|..:|:.:     |.||    |.||..|:|
Frog   452 LTPSG------QISWQTVQVQNIQSLQNLQVQN-----PGLP----QQLTLTPVS---------- 491

  Fly   535 QVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSSL 599
                       |...|:|.|     ..|::..|.|....:...|:.|..|.:        |:::|
Frog   492 -----------TSSGTTIAQ-----IAPVTVAGTPITLNAAHFTSVPNLQTV--------SVANL 532

  Fly   600 SIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTGGQVVSVTTQAR 664
            . .|.:|:..:|...|:........:.:.|.               |.||||       ||....
Frog   533 G-AAGVQVQGVPVTITSVGGQQQGAEGVKVQ---------------QATIAP-------VTVAVG 574

  Fly   665 G-ATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKPRLKRVACTCPNCT 728
            | |.|:|.:.:....|.....||..:.:..|              .||:   ||:||||:||||.
Frog   575 GIANATIGAVSPDQLTQVQLQQSQPSSDQEV--------------QTGK---RLRRVACSCPNCR 622

  Fly   729 DGEKHSD----KKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQR 789
            :||...:    ||:||||||..|.||||||||||||||||||||||||:|.||||||||||||||
Frog   623 EGEGRGNSEPGKKKQHICHIENCGKVYGKTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQR 687

  Fly   790 HRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKGGNAPKSISTVNG 854
            |||||||||||:|.||:|:||||||||||:|||               |..|||....:|.|...
Frog   688 HRRTHTGEKRFECPECSKRFMRSDHLSKHVKTH---------------QNKKGGGTALAIVTSGD 737

  Fly   855 IVTIEIPGGGSAAAGSGASSVAATVA-----GSTVTPGGAT 890
            :        .|:..|...|....|||     .:..||..:|
Frog   738 L--------DSSVTGVLGSPRIVTVAAISQDSNPATPNVST 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	81/105 (77%)
		C2H2 Zn finger	742..764	CDD:275368	18/21 (86%)
		zf-H2C2_2	756..783	CDD:290200	24/26 (92%)
		C2H2 Zn finger	772..794	CDD:275368	19/21 (90%)
		zf-H2C2_2	786..809	CDD:290200	19/22 (86%)
		zf-C2H2	800..822	CDD:278523	16/21 (76%)
		C2H2 Zn finger	802..822	CDD:275368	15/19 (79%)
sp4	XP_002933342.2	zf-C2H2	638..662	CDD:333835	20/23 (87%)
		C2H2 Zn finger	640..662	CDD:275368	18/21 (86%)
		zf-H2C2_2	654..681	CDD:372612	24/26 (92%)
		C2H2 Zn finger	670..692	CDD:275368	19/21 (90%)
		zf-H2C2_2	684..707	CDD:372612	19/22 (86%)
		zf-C2H2	698..720	CDD:333835	16/21 (76%)
		C2H2 Zn finger	700..720	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I9886
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3746
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49214
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070