DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spps and SP9

DIOPT Version :9

Sequence 1:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001138722.1	Gene:	SP9 / 100131390	HGNCID:	30690	Length:	484	Species:	Homo sapiens

Alignment Length:	331	Identity:	126/331 - (38%)
Similarity:	158/331 - (47%)	Gaps:	67/331 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 NSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVT--TSSTQITIAPTGGQV 656
            :||.|.:..||:.    .|..|..|:..:.|.....|....|...|.:  .|::|..:|..|.:.
Human   202 SSLHSGAPQASLH----SQLGTYNPDFSSLTHSAFSSTGLGSSAAAASHLLSTSQHLLAQDGFKP 262

  Fly   657 VSVTTQARGATASIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKPRLKRVA 721
            |            :.|.:.|:..:...:.|        |.:.|||....||::....:....|..
Human   263 V------------LPSYSDSSAAVAAAAAS--------AMISGAAAAAAGGSSARSARRYSGRAT 307

  Fly   722 CTCPNCTDGEKHSD------KKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKR 780
            |.||||.:.|:...      :|..|.|||.||.|||||||||:||||||||||||||:|.|||||
Human   308 CDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKR 372

  Fly   781 FTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKGGNA 845
            ||||||||||.|||||||||.|..|||:||||||||||||||                 ..||..
Human   373 FTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTH-----------------NGGGGG 420

  Fly   846 PKSISTVNGIVTIEIP-----------GGGSAAAGSGASSVAATVAGSTVTPGGATIVQLPTVEA 899
            .|...:......:|.|           .|.|||..:.|::.||..|.:..:.||..       .|
Human   421 KKGSDSDTDASNLETPRSESPDLILHDSGVSAARAAAAAAAAAAAAAAAASAGGKE-------AA 478

  Fly   900 SGGGDS 905
            ||..||
Human   479 SGPNDS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	77/107 (72%)
		C2H2 Zn finger	742..764	CDD:275368	18/21 (86%)
		zf-H2C2_2	756..783	CDD:290200	23/26 (88%)
		C2H2 Zn finger	772..794	CDD:275368	18/21 (86%)
		zf-H2C2_2	786..809	CDD:290200	18/22 (82%)
		zf-C2H2	800..822	CDD:278523	17/21 (81%)
		C2H2 Zn finger	802..822	CDD:275368	16/19 (84%)
SP9	NP_001138722.1	SP9_N	19..333	CDD:411695	34/154 (22%)
		9aaTAD, inactive. /evidence=ECO:0000269\|PubMed:31375868	178..186
		C2H2 Zn finger	337..356	CDD:275368	15/18 (83%)
		zf-H2C2_2	348..375	CDD:404364	23/26 (88%)
		C2H2 Zn finger	364..386	CDD:275368	18/21 (86%)
		zf-H2C2_2	378..401	CDD:404364	18/22 (82%)
		zf-C2H2	392..414	CDD:395048	17/21 (81%)
		C2H2 Zn finger	394..414	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..446		11/53 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010