Protein Alignment twin and ANGEL2

DIOPT Version :9

• Sequence 1: NP_732964.1
• Gene: twin / 42880
• FlyBaseID: FBgn0011725
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_653168.2
• Gene: ANGEL2 / 90806
• HGNCID: 30534
• Length: 544
• Species: Homo sapiens
• Alignment Length: 463
• Identity: 109/463 - (23%)
• Similarity: 185/463 - (39%)
• Gaps: 153/463 - (33%)

  Fly   189 QRPWLPLAKPNKTR----------PAC-------IFTVMCYNVLCDKYA--TRQMYGYCPSWALC 234
            :|.|..:...:|.:          |.|       .|:||.||:|.....  ...:|.:|....|.
Human   132 KRNWEYICSHDKEKTKILGDKNVDPKCEDSENKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLH 196

  Fly   235 WEYRKKSIIDEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYVD 299
            |.:|..:|:.||:|:.||::.|||::.:.:.....|.|::.||...:..::..|.         |
Human   197 WSFRFPNILKEIKHFDADVLCLQEVQEDHYGAEIRPSLESLGYHCEYKMRTGRKP---------D 252

  Fly   300 GCAIFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPMSEVT 364
            ||||.|:.|||:|:..:.:||.:..::           ::.:||:||..||:.|         :.
Human   253 GCAICFKHSKFSLLSVNPVEFFRPDIS-----------LLDRDNVGLVLLLQPK---------IP 297

  Fly   365 QISQPLLVCTAHIH--WDPEFCDVKLIQTMMLSNELKTIIDEASHSFRPGHKNDSNAVQLLLCGD 427
            ..:.| .:|.|:.|  ::|...|:||.|..||..|:.::          .|:.|.:...:::|||
Human   298 YAACP-AICVANTHLLYNPRRGDIKLTQLAMLLAEISSV----------AHQKDGSFCPIVMCGD 351

  Fly   428 FNSLPDSGVVEFLGKGRVSMDHLDF-KDMGYK--SCLQRLLS----------------------- 466
            |||:|.|.:..|:.:|:::.:.|.. |..|.:  |..||:||
Human   352 FNSVPGSPLYSFIKEGKLNYEGLPIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPK 416

  Fly   467 -----ND------------------TNEFTHSFKLASAYNEDIMPHTNYTFDFKGI--------- 499
                 :|                  ::...|.|.|:|.|        ::.|...||
Human   417 VEKTDSDLTQTQLKQTEVLVTAEKLSSNLQHHFSLSSVY--------SHYFPDTGIPEVTTCHSR 473

  Fly   500 ----IDYIFYTKT----------------GMVPLGLLGPVSND--WLRENKVVGCPHPHIPSDHF 542
                :|||||:..                |:..|..|..::..  |    .|.|.|:.:..|||.
Human   474 SAITVDYIFYSAEKEDVAGHPGAEVALVGGLKLLARLSLLTEQDLW----TVNGLPNENNSSDHL 534

  Fly   543 PLLVELEL 550
            |||.:..|
Human   535 PLLAKFRL 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	102/424 (24%)
ANGEL2	NP_653168.2	EEP	169..542	CDD:321002	102/424 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724242at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820