Protein Alignment twin and NGL3

DIOPT Version :10

• Sequence 1: NP_732964.1
• Gene: twin / 42880
• FlyBaseID: FBgn0011725
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_013588.1
• Gene: NGL3 / 854921
• SGDID: S000004587
• Length: 505
• Species: Saccharomyces cerevisiae
• Alignment Length: 468
• Identity: 94/468 - (20%)
• Similarity: 161/468 - (34%)
• Gaps: 149/468 - (31%)

  Fly   186 PPP-----QRPWLPLAKPNK--TRPACI--------FTVMCYNVLCDKYATRQMYGYCPSW--AL 233
            |.|     :||:||:...|.  ..||.|        ..:|.||.|......|..:   |..  ||
Yeast    73 PTPDLQFIERPFLPINHDNSKGLTPATIQVTQDSLDVKIMTYNTLAQTLIRRDFF---PESGPAL 134

  Fly   234 CWEYRKKSIIDEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYV 298
            .|..|.|.::.|::.|..|::||||::..:. :|:.......|::.||. :...||
Yeast   135 KWHKRSKVLVHELKKYRPDVVSLQEVDYNEL-NFWQENFHKLGFDVIFK-RHEGKT--------- 188

  Fly   299 DGCAIFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPMSEV 363
            .|..:.:...||.|..:.:::::.:...|...:     |...| ||.|...|..|       ...
Yeast   189 HGLLVAWNNKKFQLDNDWMLDYDNILAGNVISA-----RTRTK-NIALIISLYFK-------GIT 240

  Fly   364 TQISQPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASHSFRPGHKNDSNAVQLLLCGDF 428
            ...|:.::|...|:.|.|.....:|.|:.::..:::.|  :|...:...|.        ||.|||
Yeast   241 DSSSRGIIVANTHLFWHPFGVFERLRQSYLVLQKIQEI--KACSKYNGWHS--------LLMGDF 295

  Fly   429 NSLPDS------------------GVVE------FLGKGRVSMDHLDFKDMGYKSCLQRLLSNDT 469
            |:.|:.                  .:||      :..|........|.::...||..:.......
Yeast   296 NTEPEEPPYLAITKRPLILKGPIRAMVECSLAYRYSKKRNGEESDQDDEECDEKSRGEGHSDQPQ 360

  Fly   470 NEFTHSF-----------KLASAYNE--------------DIMPH-----------TNYTFDFKG 498
            |....||           :|.:.:|.              .:.|.           :|:...:.|
Yeast   361 NPKPESFTATKEEKALVNQLVALHNSLHVKGVSLYGIGYGKVHPENANGSHGEPGLSNWANTWCG 425

  Fly   499 IIDYIFYTKTGMVPLGLLGPVSNDWLREN-----------KVVG-----C----PHPHIP----- 538
            ::|||||.:         |..:.|..::.           |::|     |    |....|
Yeast   426 LLDYIFYIE---------GDHNQDTRQKEPLNAFEGNNNVKIIGYLRMPCAQEMPKHSQPFEGEY 481

  Fly   539 -SDHFPLLVELEL 550
             |||..|:.::.|
Yeast   482 ASDHISLMCQIRL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR	<52..>155	CDD:443914
		leucine-rich repeat	76..98	CDD:275378
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	83/428 (19%)
NGL3	NP_013588.1	CCR4	67..496	CDD:227564	94/468 (20%)