DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twin and NGL1

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_014600.1	Gene:	NGL1 / 854115	SGDID:	S000005402	Length:	363	Species:	Saccharomyces cerevisiae

Alignment Length:	399	Identity:	109/399 - (27%)
Similarity:	179/399 - (44%)	Gaps:	76/399 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 RPWLPLAKPNK------TRPACIFTVMCYNVLCDKYATRQMYGYCPSWALCWEYRKKSIIDEIRH 248
            |.::|:.:..|      .|....||::.||:|...|...|:|.|.......|.||.:.:..|:.:
Yeast     4 RRFIPVVQSTKQNIGKYVRKDARFTLLTYNMLSPSYMWPQVYTYVAEPYKNWSYRHRLLEKELLN 68

  Fly   249 -YAADIISLQEI---ETEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYV---DGCAIFFR 306
             :.|||:.|||:   :.|.::|      .:.|.:..:..|..:||..:..:|.|   ||.:||:.
Yeast    69 TFKADIMCLQEMTARDYEDYWH------DSIGVDVNYGSKFISKTPPKYWKKPVKDMDGVSIFYN 127

  Fly   307 ASKFTLIKESLIEFNQL---------------------AMANAEGSDNMLNRVMPKDNIGLAALL 350
            .:||..|..|.|..|||                     ..:|..|.|::|:.:..|:.:.|...|
Yeast   128 LAKFDFISSSGIYLNQLLNVFNQRELKYLYNKKVTLTDGASNVIGEDSLLDVLKGKNQVCLFVSL 192

  Fly   351 KVKENAWEPMSEVTQISQPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASHSFRPGHKN 415
            :.||.           ....:|...|::|  ::.:|||.|.|::..||..||.:    ..||...
Yeast   193 RHKET-----------GTIFVVLNTHLYW--KYDEVKLTQCMIIMRELSKIIKQ----LLPGDVK 240

  Fly   416 DSNAVQLLLCGDFNSLPDSGVVEFLGKGRVSMDHLDFKDMG-YKSCLQRLLSNDTNEFTHSFKLA 479
            ....|::|..||.||..||.||.|| :|:: :.|.|...:. .:..|.|.:.:|
Yeast   241 GQERVKILFTGDLNSTRDSLVVNFL-QGQI-VSHGDLNLINPMRPYLDRCVYDD----------- 292

  Fly   480 SAYNEDIMPHTNYTFDFKGIIDYIFYTKTGMVPLGLL--GPVSNDWLRENKVVGCPHPHIPSDHF 542
              ..:|...||.|:...|||.||::|..:..:...:|  ..||::.|..|: :|.|:.:.||||.
Yeast   293 --IPKDYFVHTCYSGKLKGIFDYVWYHDSDFLLTKILTGNEVSDELLASNQ-LGLPNENHPSDHI 354

  Fly   543 PLLVELELM 551
            |||.|.:::
Yeast   355 PLLTEFKIL 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	103/371 (28%)
NGL1	NP_014600.1	CCR4	1..363	CDD:227564	109/397 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1162
OMA	1	1.010	-	-		QHG57444
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12121
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870