DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment twin and Angel1

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_011242471.1	Gene:	Angel1 / 68737	MGIID:	1915987	Length:	690	Species:	Mus musculus

Alignment Length:	686	Identity:	140/686 - (20%)
Similarity:	235/686 - (34%)	Gaps:	207/686 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 MKGNHYKMSRNKDKYDSANRRQQIFLSQEDIAAGKKTNWSGLEITGCVRNISPSLWEFEHLTALY 80
            ::||.....|..|:.:.....||          .::..|:....|.....::........|..|.
Mouse    64 VEGNFAMAPRGPDQEECEGLLQQ----------WREEGWNQTPSTASEGPLADKGLAESSLALLM 118

  Fly    81 LNDNQLLRLPADVGMLTSLRTLDLSSNKLRSLPAELGELIQLRELL--LNNNFLRVLPYEIGKLF 143
            .|..:......|......|..|..:.|..:..|..|||     |.|  :.......:|.:.|..:
Mouse   119 DNSGEQDAASEDKWSSRQLSDLRAAENLNQPFPEVLGE-----EPLAEVEGPLWAAVPVQTGPQY 178

  Fly   144 ---HLVILGLMGNPLQKE-----FMNIYNEPNGTQKLLTYMLDNLSFTVNPPPQ---------RP 191
               .::.:|.|.....:|     ..:|..||...::...:..:.|. .:.|||.         |.
Mouse   179 ADCAVLPMGAMAAEQWEEDPAMVAWSIAPEPMPQEETSMWPFEGLE-QLQPPPMEIPYHEILWRE 242

  Fly   192 WLPLAKPNKTR-------PACIFTVMCYNVLCD--KYATRQMYGYCPSWALCWEYRKKSIIDEIR 247
            |...:.....:       |...||:|.||:|..  ...:.::|.:|....|.|.||..:::.|.:
Mouse   243 WEDFSTQPDAQGLEAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFANLMQEFQ 307

  Fly   248 HYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTL 312
            |:..||:.|||::.:.::....|.|:..|:...:..::..||         ||||:.::.::|.|
Mouse   308 HWDPDILCLQEVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKT---------DGCAVCYKPTRFRL 363

  Fly   313 IKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPM--SEVTQIS-QPLLVCT 374
            :..|.:|:.:..:       .:|||    ||:||..||       :|:  ..:.|:| .||.|..
Mouse   364 LCASPVEYFRPGL-------ELLNR----DNVGLVLLL-------QPLVPEGLGQVSVAPLCVAN 410

  Fly   375 AHIHWDPEFCDVKLIQTMMLSNELKTI--IDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDSGVV 437
            .|:.::|...||||.|..:|..|:..:  :.:.||            ..::||||.||:|||.:.
Mouse   411 THVLYNPRRGDVKLAQMAILLAEVDKVARLSDGSH------------CPIILCGDLNSVPDSPLY 463

  Fly   438 EFLGKGRVSMDHL---------DF---------------KDMGYKSCLQRLLS------------ 466
            .|:..|.:..:.:         ||               ..:|...|.|.:.|
Mouse   464 NFIRDGELQYNGMPAWKVSGQEDFSHQLYQRKLQAPLWPSSLGITDCCQYVTSCHPKRSERLKYG 528

  Fly   467 --------------------------NDT----------------------------NEFTHSFK 477
                                      .||                            ....|...
Mouse   529 RDFLLRFRFCDLACQRPVGLVLMEGVTDTKPDRPAGWAECIFEEEISELEPVFPRTIGTIQHCLH 593

  Fly   478 LASAYNEDIMPH-----TNYTFDFKGIIDYIFYT---------------KTGMVPLGLLGPVSND 522
            |.|.|...:..|     |.........:||||::               :.|  .|.|||.:|
Mouse   594 LTSVYTHFLPQHGCPEVTTMPLGLGMTVDYIFFSAESCENENRTDHRLDRDG--TLKLLGRLS-- 654

  Fly   523 WLRENKVV----GCPHPHIPSDHFPLLVELELMHTA 554
             |...:::    |.|:|...|||..||....:..||
Mouse   655 -LLSEEILWAANGLPNPFYSSDHLCLLASFGMEVTA 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563	7/39 (18%)
		LRR_8	75..130	CDD:290566	13/56 (23%)
		leucine-rich repeat	76..98	CDD:275378	4/21 (19%)
		LRR_4	97..136	CDD:289563	9/40 (23%)
		leucine-rich repeat	99..121	CDD:275378	7/21 (33%)
		leucine-rich repeat	122..144	CDD:275378	4/26 (15%)
		leucine-rich repeat	145..156	CDD:275378	2/10 (20%)
		Deadenylase_CCR4	209..550	CDD:197331	100/461 (22%)
Angel1	XP_011242471.1	EEP	268..683	CDD:382041	100/458 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740