DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twin and Angel2

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_067396.3	Gene:	Angel2 / 52477	MGIID:	1196310	Length:	544	Species:	Mus musculus

Alignment Length:	420	Identity:	110/420 - (26%)
Similarity:	176/420 - (41%)	Gaps:	120/420 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 FTVMCYNVLCDKYA--TRQMYGYCPSWALCWEYRKKSIIDEIRHYAADIISLQEIETEQFYHFFL 269
            |:||.||:|.....  ...:|.:|....|.|.:|..:|:.||:|:.||::.|||::.:.:.....
Mouse   167 FSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIR 231

  Fly   270 PELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAMANAEGSDNM 334
            |.|::.||...:..|:..|.         |||||.|:.|:|:|:..:.:||
Mouse   232 PSLESLGYHCEYKMKTGRKP---------DGCAICFKHSRFSLLSVNPVEF-------------- 273

  Fly   335 LNRVMP---KDNIGLAALLKVKENAWEPMSEVTQISQP-LLVCTAHIHWDPEFCDVKLIQTMMLS 395
            ..|.:|   :|||||..||:.|         :.:.:.| :.:...|:.::|...|:||.|..||.
Mouse   274 CRRDIPLLDRDNIGLVLLLQPK---------IPRAASPSICIANTHLLYNPRRGDIKLTQLAMLL 329

  Fly   396 NELKTIIDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDSGVVEFLGKGRVSMDHLDF-KDMGYK- 458
            .|:..:.          |:.|.::..:::||||||:|.|.:..|:.:|:::.:.|.. |..|.:
Mouse   330 AEIANVT----------HRKDGSSCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQ 384

  Fly   459 -SCLQRLLS----------------------------ND------------------TNEFTHSF 476
             |..||:||                            :|                  ::...|.|
Mouse   385 SSRGQRILSIPIWPPNLGISQNCVYEAQQVPKVEKTDSDVTQAQQEKAEVPVSADKVSSHLQHGF 449

  Fly   477 KLASAYNEDI----MPHTNYTFDFKGI-IDYIFYT----KTGMVP---------LGLLGPVSNDW 523
            .|:|.|:..:    :|..........| :||||||    .|...|         |.||..:|  .
Mouse   450 SLSSVYSHYVPDTGVPEVTTCHSRSAITVDYIFYTAKKENTAQGPGAEVALVGGLKLLARLS--L 512

  Fly   524 LREN---KVVGCPHPHIPSDHFPLLVELEL 550
            |.|.   .|.|.|:.|..|||.|||.:..|
Mouse   513 LTEQDLWTVNGLPNEHNSSDHLPLLAKFRL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	108/416 (26%)
Angel2	NP_067396.3	EEP	169..542	CDD:294334	108/416 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810