DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twin and cu

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001097746.1	Gene:	cu / 41339	FlyBaseID:	FBgn0261808	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	350	Identity:	88/350 - (25%)
Similarity:	140/350 - (40%)	Gaps:	81/350 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 CPSWALCWEYRKKSIIDEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKSRAKTMSE 292
            ||..||.||:||..|:.||.....|:|.|||::   .:.|....|.:..|.|||.||..:..:..
  Fly   333 CPEEALTWEHRKYLIVQEILQNQPDVICLQEVD---HFKFLQTVLGSQNYAGIFFPKPDSPCLYI 394

  Fly   293 LERKYVDGCAIFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRV--MPKDNIGLAALLKVKEN 355
            .:....||||||::..|..|                :|.|..:..|  :..:.:.:||.|:::.:
  Fly   395 EQNNGPDGCAIFYKRDKLQL----------------QGYDTRILEVWRVQSNQVAIAARLRMRSS 443

  Fly   356 AWEPMSEVTQISQPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASHSFRPGHKNDSNAV 420
            ..|             .|.|..|       :|.....:|:.    :.:|.........|..:...
  Fly   444 GRE-------------FCVATTH-------LKARHGALLAK----LRNEQGRDLIRFVKQFAGDT 484

  Fly   421 QLLLCGDFNSLPDSGV------VEFLGKGRVSMD-HLDFKDMGYKSCLQRLLSNDTNEFTHSFKL 478
            .||||||||:.|...:      .:.|..|....| .||.:::.:.:.       |..||     :
  Fly   485 PLLLCGDFNAEPVEPIYATILGCDLLRLGSAYADVKLDREEILHPNA-------DVGEF-----V 537

  Fly   479 ASAYNEDIMPHTNYTFDFKG----IIDYIFYTKTGMVPLGLLGPVSNDWLRENKVVGCPHPHIPS 539
            |.:...: .|:|.:....:|    .|||:|||...:.....|...:.:.:.:|:.   |....||
  Fly   538 AKSMKRE-PPYTTWKIREEGEECHTIDYVFYTPDRLKIKNCLDFPAGEQIGKNRT---PSFQYPS 598

  Fly   540 DHFPLLVELELMHTASQQAPP--NG 562
            |||.|:.:.||:       ||  ||
  Fly   599 DHFSLVCDFELL-------PPTENG 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	82/334 (25%)
cu	NP_001097746.1	EEP	312..609	CDD:382041	82/334 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724242at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12121
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850