DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twin and angel

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_477204.1	Gene:	angel / 37748	FlyBaseID:	FBgn0016762	Length:	354	Species:	Drosophila melanogaster

Alignment Length:	383	Identity:	100/383 - (26%)
Similarity:	156/383 - (40%)	Gaps:	111/383 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 RPWLPLAK------PNKTRPACIFTVMCYNVLCDKYATRQMYGY--CPSWALCWEYRKKSIIDEI 246
            |.|..|..      |:|   ...|.|:.||:|........::.|  .|...|.|:.|:::::.|:
  Fly    48 RRWTSLGNQAEGRDPHK---CSSFKVVSYNILAQDLLLEHLFLYVGIPHEFLSWQRRQQNLLREL 109

  Fly   247 RHYAADIISLQEIETEQFYHFFLPEL---------KNDGYEGIFSPKSRAKTMSELERKYVDGCA 302
            .....||:.|||:   ||.|  ||.|         |...|  ::..|:..:|         ||||
  Fly   110 LKLDPDILCLQEM---QFDH--LPVLVQRLRMGNGKKLAY--VYKKKTGCRT---------DGCA 158

  Fly   303 IFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPMSEVTQIS 367
            |.:.:|||.|:....:|....|:|       :|||    ||:.|.|..:.|:.. |...|
  Fly   159 IVYDSSKFELLDHQAVELYDQAVA-------LLNR----DNVALFARFRFKKQQ-EQQKE----- 206

  Fly   368 QPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASHSFRPGHKNDSNAVQLLLCGDFNSLP 432
              .:|.|.|:.::.:..||:..|...:..||::.               |....::|.|||||||
  Fly   207 --FVVATTHLLFNTKRSDVRCAQVERILEELQSF---------------STDTPIVLTGDFNSLP 254

  Fly   433 DSGVVEFL-GKGRVSMDHLDFKDMGYKSCLQRLLSN--DTNEFTHSFKLASAYNEDIMPHTNYTF 494
            ||..:||| ||.         .|:...:|.:.|...  |:.|.|     ||.|..:.:
  Fly   255 DSSPIEFLVGKN---------GDVDSTACPEPLHFEIIDSGEGT-----ASTYQNEWV------- 298

  Fly   495 DFKGIIDYIF-----YTKTGMVPLGLLGPVSNDWLRENKVVGC---PHPHIPSDHFPL 544
                |:|||.     .::..::||.:....|     .|:.:|.   |:..:.|||:.|
  Fly   299 ----IVDYILRSLGSRSRHKLLPLSVYSLPS-----INRCIGAGQIPNYRLGSDHYAL 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	94/358 (26%)
angel	NP_477204.1	EEP	70..351	CDD:294334	94/358 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12121
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840