DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twin and CG31759

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_723735.2	Gene:	CG31759 / 326158	FlyBaseID:	FBgn0051759	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	118/447 - (26%)
Similarity:	198/447 - (44%)	Gaps:	94/447 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 VLPYEIGKLFHLVI-------LGLMGNPLQKEFMNIYNEPNGTQKLLTYMLDNLSFTVNPPPQRP 191
            |.|.:||  :||..       ||:.|..::|...:...|..|.    ....|....|.|
  Fly   177 VTPEDIG--YHLKFVVTPGNALGMTGPVVEKITNSAVQESPGR----CPFQDRQRHTTN------ 229

  Fly   192 WLPLAKPNKTRPACIFTVMCYNVLCDKYATRQ-----MYGYCPSWALCWEYRKKSIIDEIRHYAA 251
              .|::.|:.|      |:.||:|.|.||:..     ::.|||:..|..:|||...|:||..|.:
  Fly   230 --SLSESNEIR------VVSYNLLADLYASSDYAGSTLFSYCPAKYLQIDYRKPLFINEIIGYNS 286

  Fly   252 DIISLQEIETEQFYHFFLPELKND---GYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTLI 313
            ||:.|||:: ::.:.|.|.|:...   .|.||.:||.          |..:|.|||||.|:|.|:
  Fly   287 DILCLQEVD-QRIFDFDLKEILEQPPYNYHGIMAPKG----------KCAEGVAIFFRNSRFDLL 340

  Fly   314 KESLIE--------------FNQLAMANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPMSEVT 364
            ...::.              :|::.: ||:    :..|:..:.......||::|..
  Fly   341 DSQILHLGSNIPALPVFESLWNKIKV-NAQ----LAERICERSTTLQTCLLRIKGT--------- 391

  Fly   365 QISQPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASHSFR-PGHKNDSNAVQLLLCGDF 428
              ...:||...|:::.|:...::|:|.......::..|.:|...|. ..|||    :.|:.||||
  Fly   392 --DNYVLVANTHLYFHPDADHIRLLQMGFSMLFVEQSISKAIKDFNISSHKN----IGLIFCGDF 450

  Fly   429 NSLPDSGVVEFLGKGRVSMDHLDFKDM-GYKSCLQRLLSNDTNEFTHSFKLASAYNEDIMPHTNY 492
            ||:|:.|:.:.:      .:.|..|.: .::|..::.:||  .|....||:||||...  .:|:|
  Fly   451 NSVPECGIYKLM------TEQLAEKTLEDWQSNAEQAVSN--VELAQPFKMASAYGAP--EYTHY 505

  Fly   493 TFDFKGIIDYIFYTKTGMVPLGLLGPVSNDWLRENKVVGCPHPHIPSDHFPLLVELE 549
            |..|.|.:||:||.......|.::...:.:.|:.|..:  |....||||..|:.:|:
  Fly   506 TTLFAGCLDYVFYQNDRFEVLKVVPLPTEEELKANTAI--PSAVFPSDHVALVADLK 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563	1/1 (100%)
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378	4/9 (44%)
		leucine-rich repeat	145..156	CDD:275378	4/17 (24%)
		Deadenylase_CCR4	209..550	CDD:197331	100/365 (27%)
CG31759	NP_723735.2	EEP	239..561	CDD:294334	100/365 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443968
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724242at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12121
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850