DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twin and Pde12

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001014020.2	Gene:	Pde12 / 306231	RGDID:	1310975	Length:	705	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	100/319 - (31%)
Similarity:	144/319 - (45%)	Gaps:	59/319 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 TRPACIFTVMCYNVLCDKYATRQ-----MYGYCPSWALCWEYRKKSIIDEIRHYAADIISLQEIE 260
            |..:.|.|| .||:|.|.||..:     :|.||..:||..:||:..|..|:..|.||:|.|||::
  Rat   256 TEDSFIRTV-SYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVD 319

  Fly   261 TEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAM 325
            ...|....:|.|:..|.||:|..|..            :|.|.|:|.|||.|:.:..|.|.:
  Rat   320 RAVFSDSLVPALEAFGLEGVFRIKQH------------EGLATFYRKSKFRLLSQHDISFQE--- 369

  Fly   326 ANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPMSEVTQI---------SQPLLVCTAHIHWDP 381
              |..||.:...::.|..:...|..||.:.     |.|.||         |:.:.|...|::|.|
  Rat   370 --ALKSDPLHKELLEKLALNPLAQEKVLQR-----SSVLQISVLQSTTDSSKKICVANTHLYWHP 427

  Fly   382 EFCDVKLIQTMMLSNELKTIIDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDSGVVEFLGKGRVS 446
            :...::|||.......::.:    |....||       :.::.||||||.|.:|:..|:..|.|.
  Rat   428 KGGYIRLIQMAAALVHIRHV----SCDLYPG-------IPVIFCGDFNSTPSTGMYHFVINGSVP 481

  Fly   447 MDHLDFKDMGYKS-CLQRLLSNDTNEFTHSFKLASAYNEDIMPHTNYTFDFKGIIDYIF 504
            .||.|:...|.:. |...|        ||.|||.||..|.  .:|||...|.|.:||||
  Rat   482 EDHEDWASNGEEERCGMSL--------THCFKLKSACGEP--AYTNYVGGFHGCLDYIF 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	97/311 (31%)
Pde12	NP_001014020.2	EEP	265..539	CDD:294334	96/309 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724242at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920