Protein Alignment twin and CNOT6L

DIOPT Version :10

• Sequence 1: NP_732964.1
• Gene: twin / 42880
• FlyBaseID: FBgn0011725
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001374771.1
• Gene: CNOT6L / 246175
• HGNCID: 18042
• Length: 616
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 323/559 - (57%)
• Similarity: 408/559 - (72%)
• Gaps: 29/559 - (5%)

  Fly    27 KDKYDSAN-RRQQIFLSQEDIAAGKKTNWSGLEITGCVRNISPSLWEFEHLTALYLNDNQLLRLP 90
            |:|||..: ||....:|.|::|.|||::|:.|||:|.||::|.|||...|||||:||||.|.|:|
Human    69 KEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIP 133

  Fly    91 ADVGMLTSLRTLDLSSNKLRSLPAELGELIQLRELLLNNNFLRVLPYEIGKLFHLVILGLMGNPL 155
            .|:..|.:|..||||||||||||||||.::.|||||||||.|||||||:|:||.|..|||.||||
Human   134 PDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 198

  Fly   156 QKEFMNIYNEPNGTQKLLTYMLDNLSFTVNPPPQRPWLPLAKPNKTRPACIFTVMCYNVLCDKYA 220
            .::.:|:|.:|:||:|||.:|||||:......|.|||:.|.:.::..|:..||||||||||||||
Human   199 SQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYA 263

  Fly   221 TRQMYGYCPSWALCWEYRKKSIIDEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKS 285
            |||:|||||||||.||||||.|::||.:..||||||||:||||::..|||.||..||:|.|||||
Human   264 TRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKS 328

  Fly   286 RAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALL 350
            |||.|||.|||:||||||||:..||||:::..:||||:||||::||:.||||||.|||||:|.:|
Human   329 RAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVL 393

  Fly   351 KVKENAW----EPMSEVTQISQPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASHSFRP 411
            :|.:..:    :|:....:  |.|:|..||:|||||:.|||||||||..:|:|.|:::||.  ||
Human   394 EVHKELFGAGMKPIHAADK--QLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASS--RP 454

  Fly   412 GHKN-DSNAVQLLLCGDFNSLPDSGVVEFLGKGRVSMDHLDFKDMGYKSCLQRLLSNDTN----- 470
            |... |.|::.|:||.|.||||||||||:|..|.|:.:|.|||::.|..||.....|..|
Human   455 GSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEG 519

  Fly   471 EFTHSFKLASAYNEDIMPHTNYTFDFKGIIDYIFYTKTGMVPLGLLGPVSNDWLRENKVVGCPHP 535
            ..||.|:|.|||..::||:|||||||||:||||||:||.|..||:|||:...||.||.:.|||||
Human   520 RITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHP 584

  Fly   536 HIPSDHFPLLVELELMHTASQQAPP-----NG--LINRR 567
            |||||||.||.:||| |      ||     ||  |.|||
Human   585 HIPSDHFSLLTQLEL-H------PPLLPLVNGVHLPNRR 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR	<52..>155	CDD:443914	67/102 (66%)
		leucine-rich repeat	76..98	CDD:275378	13/21 (62%)
		leucine-rich repeat	99..121	CDD:275378	17/21 (81%)
		leucine-rich repeat	122..144	CDD:275378	18/21 (86%)
		leucine-rich repeat	145..156	CDD:275378	7/10 (70%)
		Deadenylase_CCR4	209..550	CDD:197331	210/350 (60%)
CNOT6L	NP_001374771.1	LRR	<99..>199	CDD:443914	67/99 (68%)
		leucine-rich repeat	99..118	CDD:275378	10/18 (56%)
		leucine-rich repeat	119..141	CDD:275378	13/21 (62%)
		leucine-rich repeat	142..156	CDD:275378	11/13 (85%)
		Deadenylase_CCR4b	252..599	CDD:197339	210/350 (60%)