DRSC/TRiP Functional Genomics Resources

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Protein Alignment twin and CNOT6L

DIOPT Version :9

Sequence 1:NP_732964.1 Gene:twin / 42880 FlyBaseID:FBgn0011725 Length:567 Species:Drosophila melanogaster
Sequence 2:NP_001374771.1 Gene:CNOT6L / 246175 HGNCID:18042 Length:616 Species:Homo sapiens


Alignment Length:559 Identity:323/559 - (57%)
Similarity:408/559 - (72%) Gaps:29/559 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 KDKYDSAN-RRQQIFLSQEDIAAGKKTNWSGLEITGCVRNISPSLWEFEHLTALYLNDNQLLRLP 90
            |:|||..: ||....:|.|::|.|||::|:.|||:|.||::|.|||...|||||:||||.|.|:|
Human    69 KEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIP 133

  Fly    91 ADVGMLTSLRTLDLSSNKLRSLPAELGELIQLRELLLNNNFLRVLPYEIGKLFHLVILGLMGNPL 155
            .|:..|.:|..||||||||||||||||.::.|||||||||.|||||||:|:||.|..|||.||||
Human   134 PDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 198

  Fly   156 QKEFMNIYNEPNGTQKLLTYMLDNLSFTVNPPPQRPWLPLAKPNKTRPACIFTVMCYNVLCDKYA 220
            .::.:|:|.:|:||:|||.:|||||:......|.|||:.|.:.::..|:..||||||||||||||
Human   199 SQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYA 263

  Fly   221 TRQMYGYCPSWALCWEYRKKSIIDEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKS 285
            |||:|||||||||.||||||.|::||.:..||||||||:||||::..|||.||..||:|.|||||
Human   264 TRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKS 328

  Fly   286 RAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALL 350
            |||.|||.|||:||||||||:..||||:::..:||||:||||::||:.||||||.|||||:|.:|
Human   329 RAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVL 393

  Fly   351 KVKENAW----EPMSEVTQISQPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASHSFRP 411
            :|.:..:    :|:....:  |.|:|..||:|||||:.|||||||||..:|:|.|:::||.  ||
Human   394 EVHKELFGAGMKPIHAADK--QLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASS--RP 454

  Fly   412 GHKN-DSNAVQLLLCGDFNSLPDSGVVEFLGKGRVSMDHLDFKDMGYKSCLQRLLSNDTN----- 470
            |... |.|::.|:||.|.||||||||||:|..|.|:.:|.|||::.|..||.....|..|     
Human   455 GSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEG 519

  Fly   471 EFTHSFKLASAYNEDIMPHTNYTFDFKGIIDYIFYTKTGMVPLGLLGPVSNDWLRENKVVGCPHP 535
            ..||.|:|.|||..::||:|||||||||:||||||:||.|..||:|||:...||.||.:.|||||
Human   520 RITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHP 584

  Fly   536 HIPSDHFPLLVELELMHTASQQAPP-----NG--LINRR 567
            |||||||.||.:||| |      ||     ||  |.|||
Human   585 HIPSDHFSLLTQLEL-H------PPLLPLVNGVHLPNRR 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
twinNP_732964.1 LRR_4 74..114 CDD:289563 26/39 (67%)
LRR_8 75..130 CDD:290566 38/54 (70%)
leucine-rich repeat 76..98 CDD:275378 13/21 (62%)
LRR_4 97..136 CDD:289563 29/38 (76%)
leucine-rich repeat 99..121 CDD:275378 17/21 (81%)
leucine-rich repeat 122..144 CDD:275378 18/21 (86%)
leucine-rich repeat 145..156 CDD:275378 7/10 (70%)
Deadenylase_CCR4 209..550 CDD:197331 210/350 (60%)
CNOT6LNP_001374771.1 leucine-rich repeat 99..118 CDD:275378 10/18 (56%)
LRR <118..>244 CDD:227223 76/125 (61%)
leucine-rich repeat 119..141 CDD:275378 13/21 (62%)
leucine-rich repeat 142..156 CDD:275378 11/13 (85%)
Deadenylase_CCR4b 252..599 CDD:197339 210/350 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143746
Domainoid 1 1.000 416 1.000 Domainoid score I660
eggNOG 1 0.900 - - E1_COG5239
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H100830
Inparanoid 1 1.050 636 1.000 Inparanoid score I830
Isobase 1 0.950 - 0 Normalized mean entropy S1162
OMA 1 1.010 - - QHG57444
OrthoDB 1 1.010 - - D208223at33208
OrthoFinder 1 1.000 - - FOG0002437
OrthoInspector 1 1.000 - - otm40774
orthoMCL 1 0.900 - - OOG6_101771
Panther 1 1.100 - - O PTHR12121
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3216
SonicParanoid 1 1.000 - - X1441
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1615.790

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