Protein Alignment twin and ANGEL1

DIOPT Version :9

• Sequence 1: NP_732964.1
• Gene: twin / 42880
• FlyBaseID: FBgn0011725
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001357675.1
• Gene: ANGEL1 / 23357
• HGNCID: 19961
• Length: 744
• Species: Homo sapiens
• Alignment Length: 406
• Identity: 103/406 - (25%)
• Similarity: 169/406 - (41%)
• Gaps: 102/406 - (25%)

  Fly   121 QLRELLLNNNFLRVLPYEIGKLFHLVILGLMGN-----PLQKE---------------------- 158
            ||.:|....|.....|..:|:...|.:.|:.|:     |:|.|
Human   113 QLSDLRAAENLDEPFPEMLGEEPLLEVEGVEGSMWAAIPMQSEPQYADCAALPVGALATEQWEED 177

  Fly   159 ----FMNIYNEPNGTQKLLTYMLDNLSFTVNPPP---------QRPW-----LPLAKPNKT--RP 203
                ..:|..||...::...:..:.|. .:.||.         .|.|     .|.|:..|.  .|
Human   178 PAVLAWSIAPEPVPQEEASIWPFEGLG-QLQPPAVEIPYHEILWREWEDFSTQPDAQGLKAGDGP 241

  Fly   204 ACIFTVMCYNVLCD--KYATRQMYGYCPSWALCWEYRKKSIIDEIRHYAADIISLQEIETEQFYH 266
            ...||:|.||:|..  ...:.::|.:|....|.|.||..:::.|.:|:..||:.|||::.:.::.
Human   242 QFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQEVQEDHYWE 306

  Fly   267 FFLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAMANAEGS 331
            ...|.|:..|:...:..::..||         ||||:.::.::|.|:..|.:|:.:..:
Human   307 QLEPSLRMMGFTCFYKRRTGCKT---------DGCAVCYKPTRFRLLCASPVEYFRPGL------ 356

  Fly   332 DNMLNRVMPKDNIGLAALLKVKENAWEPM--SEVTQIS-QPLLVCTAHIHWDPEFCDVKLIQTMM 393
             .:|||    ||:||..||       :|:  ..:.|:| .||.|...||.::|...||||.|..:
Human   357 -ELLNR----DNVGLVLLL-------QPLVPEGLGQVSVAPLCVANTHILYNPRRGDVKLAQMAI 409

  Fly   394 LSNELKTI--IDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDSGVVEFLGKGRVSMDHLDFKDM- 455
            |..|:..:  :.:.||            ..::||||.||:|||.:..|:..|     .|.:..|
Human   410 LLAEVDKVARLSDGSH------------CPIILCGDLNSVPDSPLYNFIRDG-----ELQYHGMP 457

  Fly   456 GYKS--CLQRLLSNDT 469
            .:||  .|.||..|.|
Human   458 AWKSLALLPRLECNGT 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566	3/8 (38%)
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563	4/14 (29%)
		leucine-rich repeat	99..121	CDD:275378	103/406 (25%)
		leucine-rich repeat	122..144	CDD:275378	5/21 (24%)
		leucine-rich repeat	145..156	CDD:275378	4/15 (27%)
		Deadenylase_CCR4	209..550	CDD:197331	77/271 (28%)
ANGEL1	NP_001357675.1	EEP	248..>449	CDD:351117	67/239 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740