DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twin and Pde12

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_848783.3	Gene:	Pde12 / 211948	MGIID:	2443226	Length:	608	Species:	Mus musculus

Alignment Length:	376	Identity:	110/376 - (29%)
Similarity:	163/376 - (43%)	Gaps:	85/376 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 TRPACIFTVMCYNVLCDKYATRQ-----MYGYCPSWALCWEYRKKSIIDEIRHYAADIISLQEIE 260
            |..:.|.|| .||:|.|.||..:     :|.||..:||..:||:..|..|:..|.||:|.|||::
Mouse   289 TEDSFIRTV-SYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVD 352

  Fly   261 TEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAM 325
            ...|....:|.|:..|.||:|..|..            :|.|.|:|.|||.|:.:..|.|.:
Mouse   353 RAVFSDSLVPALEAFGLEGVFRIKQH------------EGLATFYRKSKFRLLSQHDISFQE--- 402

  Fly   326 ANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPMSEVTQI---------SQPLLVCTAHIHWDP 381
              |..||.:...::.|..:...|..||.:.     |.|.||         |:.:.|...|::|.|
Mouse   403 --ALKSDPLHKELLEKLALNPLAQEKVLQR-----SSVLQISVLQSTTDSSKKICVANTHLYWHP 460

  Fly   382 EFCDVKLIQTMMLSNELKTI-IDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDSGVVEFLGKGRV 445
            :...::|||.     |:..: |...|....||       :.::.||||||.|.:|:..|:..|.:
Mouse   461 KGGYIRLIQM-----EVALVHIRHVSRDLYPG-------IPVIFCGDFNSTPSTGMYHFVISGSI 513

  Fly   446 SMDHLDFKDMGYKSCLQRLLSNDTNEFTHSFKLASAYNEDIMPHTNYTFDFKGIIDYIFYTKTGM 510
            :.||.|:...|.:......||       |.|||.||..|.  .:|||...|.|.:||||
Mouse   514 AEDHEDWASNGEEERCSMPLS-------HCFKLKSACGEP--AYTNYVGGFHGCLDYIF------ 563

  Fly   511 VPLGLLGPVSNDWLRENKVVGCP-HPHI-----------PSDHFPLLVELE 549
                    :..:.|...:|:..| |..:           ||||..|:.:|:
Mouse   564 --------IDLNTLEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLK 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	107/368 (29%)
Pde12	NP_848783.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..111
Pde12	NP_848783.3	EEP	298..607	CDD:294334	106/366 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724242at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820