DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twin and angl-1

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001303707.1	Gene:	angl-1 / 189127	WormBaseID:	WBGene00020955	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	244	Identity:	66/244 - (27%)
Similarity:	112/244 - (45%)	Gaps:	47/244 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 FTVMCYNVLCDKYATRQMYGY----CPSWALCWEYRKKSIIDEIRHYAADIISLQEIETEQFYHF 267
            ||:..|||||.|...|..|.|    ..:..|.||:|.:.:..|:..:.|||:.|||::.:.|...
Worm   276 FTICSYNVLCQKTIARTDYLYRHLQGSAQFLDWEHRWRGLQVELPTFDADILGLQEVQADHFVEH 340

  Fly   268 FLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTLIKESLIEF--NQLAMANAEG 330
            |.|.:|..||||::..|...:...       ||||:|:..:||.|:....:.:  :..|::|
Worm   341 FQPLMKKYGYEGVYKQKFGTQQKD-------DGCALFYHPAKFELVANQEVNYFISDTAISN--- 395

  Fly   331 SDNMLNRVMPKDNIGLAALLKVKENAWEPMSEVTQISQPLLVCTAHIHWDPEFCDVKLIQTMMLS 395
                      ::||.....|:.:         :|:  :.:||...|:.::.|..||||.|..:|.
Worm   396 ----------RENIAQIVALRCR---------ITK--ELILVANTHLLFNEERGDVKLAQLAILF 439

  Fly   396 NELKTIIDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDSGVVEFLGKGR 444
            ..:..:.::.:....|          :.:.||||..|:|.|.:|:..||
Worm   440 ASIHKMREDFAPMVPP----------VFVMGDFNIEPNSKVYDFIVDGR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	64/242 (26%)
angl-1	NP_001303707.1	EEP	280..>478	CDD:382041	62/238 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724242at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820